Complete unilateral vision loss and optic nerve cupping from metastatic prostate cancer to the optic canal

2021 ◽  
Vol 14 (1) ◽  
pp. e236685
Author(s):  
Aaron T Chan ◽  
Jonathan A Micieli
Keyword(s):  
Prostate Cancer ◽  
Optic Nerve ◽  
Optic Disc ◽  
Vision Loss ◽  
The Body ◽  
Optic Canal ◽  
Neuroretinal Rim ◽  
Bone Expansion ◽  
Castrate Resistant ◽  
Optic Disc Cupping

A 71-year-old man, living with metastatic castrate-resistant prostate cancer to the lymph nodes, spine and skull, presented with acute on chronic left eye vision loss. Examination revealed no-light-perception vision, a relative afferent pupillary defect and optic disc cupping. MRI brain revealed optic canal narrowing from metastatic sphenoid bone expansion and extraosseous tumour compressing the intracanalicular optic nerve. The optic disc cupping and excavation without significant pallor of the remaining neuroretinal rim was likely secondary to chronic compression of the optic nerve. The patient was treated with radiation therapy, but did not regain vision and was referred to palliative care as his condition continued to worsen. As patients live longer with advanced cancer, there is a greater risk of metastasis to atypical areas of the body including the optic nerve. This case demonstrates the unique combination of optic disc cupping from optic canal metastasis due to prostate cancer.

scholarly journals Automatic Diagnosis of Glaucoma using Image Processing Technique

2019 ◽  
Vol 9 (2) ◽  
pp. 3984-3987
Keyword(s):  
Optic Nerve ◽  
Optic Disc ◽  
Vision Loss ◽  
Early Stage ◽  
Threshold Value ◽  
Processing Technique ◽  
Least Square ◽  
Disc Height ◽  
Image Processing Technique ◽  
Human Eye

Glaucoma is a human eye condition which will affect the optic nerve present in the retina. This condition occurs due to the abnormal ocular pressure in human eye. If it is not diagnosed and treated well in advance, it may lead to blindness. This is the major problem of elderly people all over the world. The best way to avoid vision loss due to glaucoma is to detect the disease at the early stage and treat it as soon as possible. These are the keys to prevent blindness. As vision is an important organ in human body it is advisable to keep it healthy. The optic cup in the retina will be pulled in towards the optic nerve away from the optic disc. At one point, the cup will be detached from the retina, causing blindness. So if one can monitor by measuring the optic disc to cup ratio, the progression of glaucoma can be diagnosed earlier. The proposed method detects the optic disc and cup using thresholding method. Direct least square fitting algorithm is used here to fit the ellipse in order to calculate the cup height and disc height. Then the ratio is calculated. If the calculated ratio is above the threshold value, it is considered as glaucoma affected eye otherwise not. The CDR is calculated using the formula VDH/VCH (Vertical Disc Height to the Vertical Cup Height). Thus, the proposed method helps to automatically detect the glaucoma disease with better sensitivity and specificity.

scholarly journals Low Subfrontal Dural Opening for Anterior Clinoid Meningioma

2018 ◽  
Vol 79 (S 03) ◽  
pp. S273-S275
Author(s):  
Michael Chicoine
Keyword(s):  
Optic Nerve ◽  
Surgical Technique ◽  
Vision Loss ◽  
Tumor Resection ◽  
Postoperative Recovery ◽  
Vascular Lesions ◽  
Optic Canal ◽  
The Novel ◽  
Dural Opening ◽  
Brain Retraction

Introduction A variety of dural openings are described for frontal–temporal and cranio-orbital craniotomies. As with any surgical technique, the goal is to optimally and safely address the pathology, minimize normal anatomy disruption, and optimize postoperative recovery. This study reports a modified dural opening for frontal–temporal approaches which minimizes brain exposure while facilitating visualization for neoplastic and vascular lesions of the anterior clinoid, supra- and parasellar and adjacent regions. Methods A sample case is presented for which a low subfrontal dural exposure was utilized for tumor resection. The clinical presentation, surgical procedure, and outcome are summarized including a video detailing the surgical technique. Results A 63-year-old female with gradual left eye vision loss and tumor enlargement on serial imaging. The small dural-based tumor arose from the left anterior clinoid and optic canal region compressing the optic nerve. The video shows a left frontal–temporal craniotomy used to perform extradural anterior clinoidectomy and optic canal decompression. The novel low subfrontal dural opening without fixed brain retraction allowed dural opening around the optic canal and clinoidectomy region to resect tumor and complete optic nerve decompression. Postoperatively, the patient did well with significant recovery of vision and follow-up at 2.5 years shows no evidence of tumor recurrence. Conclusion The novel low subfrontal dural opening provides access to lesions of the supra-and para-sellar and adjacent regions, and preservation of much of the dura avoids some of the risks of intradural dissection including Sylvian fissure dissection and brain retractionThe link to the video can be found at: https://youtu.be/Jc7wvR4PTFk.

scholarly journals Glaucoma Detection from Color Fundus Images

2012 ◽  
pp. 261-264
Author(s):  
Madhusudan Mishra ◽  
Malaya Kumar Nath ◽  
Samarendra Dandapat
Keyword(s):  
Optic Nerve ◽  
Optic Disc ◽  
Vision Loss ◽  
Pathological Condition ◽  
Pathological Process ◽  
Contour Method ◽  
Fundus Images ◽  
Progressive Neurodegeneration ◽  
Color Fundus Images ◽  
Cup To Disc Ratio

Glaucoma is a pathological condition, progressive neurodegeneration of the optic nerve, which causes vision loss. The damage to the optic nerve occurs due to the increase in pressure within the eye. Glaucoma is evaluated by monitoring intra ocular pressure (IOP), visual field and the optic disc appearance (cup-to-disc ratio). Cup-to disc ratio (CDR) is normally a time invariant feature. Therefore, it is one of the most accepted indicator of this disease and the disease progression. In this paper, active contour method is used to find the CDR from the color fundus images to determine pathological process of glaucoma. The method is applied on 25 nos of color fundus images obtained from optic disc organization UK having normal and pathological images. The proposed technique able to categorize all the glaucoma disease images.

scholarly journals Comparing characteristics of the optic nerve head among subjects with suspected glaucoma in different ages of onset

2018 ◽  
Vol 146 (3-4) ◽  
pp. 136-142
Author(s):  
Vesna Maric ◽  
Vujica Markovic ◽  
Marija Bozic ◽  
Ivan Marjanovic
Keyword(s):  
Optic Nerve ◽  
Nerve Fiber ◽  
Layer Thickness ◽  
Optic Disc ◽  
Retinal Nerve Fiber Layer ◽  
Optic Nerve Head ◽  
Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Neuroretinal Rim ◽  
Disc Area

Introduction/Objective. Evaluation of the optic nerve head (ONH) is an inevitable procedure in the diagnosis of glaucoma. One of the most common imaging techniques for a quantitative assessment of the topography of the ONH is the Heidelberg retinal tomography II (HRT II). The aim of this study was to determine quantitative stereometric parameters of the ONH by using the HRT II and to investigate any damage of neuroretinal rim in children with suspected glaucoma and compared these data with the group of adults with suspected glaucoma. Methods. This comparative study included 167 (167 eyes) children aged 11?3 years with suspected juvenile glaucoma and 175 adult participants (175 eyes), aged 60?3 years, also with suspected glaucoma, examined between January 2013 and April 2014. Optic nerve head topography and retinal nerve fiber layer thickness measurements were assessed using a HRT II. Results. Data analysis in this study showed that the average mean values for children/adults were: disc area (mm2) 2.828?0.489/2.663?0.412 (p<0.001); rim area (mm2) 1.873?0.391/1.667?0.275 (p<0.001); cup/disc area ratio 0.369?0.125/0.369?0.101 (p=0.530); mean retinal nerve fiber layer thickness (mm) 0.223?0.078/0.219?0.055 (p=0.494). Statistically significant difference in damage of neuroretinal rim, between children and adults, was found in temporal (T) and temporal-inferior (Ti) segments. Conclusions. There were differences in some of the investigated quantitative parameters of the ONH between children and adults, as optic disc size, cup and rim area and rim volume. By using MRA, difference in the damage of the neuroretinal rim, when comparing children and adult optic discs appeared only in T and Ti segments, which means that optic disc cupping has spread more in children than in adults.

Oct1 regulates cell growth of LNCaP cells and is a prognostic factor for prostate cancer

2020 ◽  
Author(s):  
Lungwani Muungo
Keyword(s):  
Prostate Cancer ◽  
Prognostic Factor ◽  
Hazard Analysis ◽  
Critical Role ◽  
Immunohistochemical Analysis ◽  
Lncap Cells ◽  
Cancer Specific Survival ◽  
High Gleason Score ◽  
Castrate Resistant ◽  
Transcription Factor 1

The androgen receptor (AR) plays a critical role in the development and the progression of prostate cancer. Alterations in theexpression of AR coregulators lead to AR hypersensitivity, which is one of the mechanisms underlying the progression ofprostate cancer into a castrate-resistant state. Octamer transcription factor 1 (Oct1) is a ubiquitous member of the POUhomeodomainfamily that functions as a coregulator of AR. In our study, the contribution of Oct1 to prostate cancerdevelopment was examined. Immunocytochemistry analysis showed that Oct1 is expressed in the nuclei of LNCaP cells.siRNA-mediated silencing of Oct1 expression inhibited LNCaP cell proliferation. Immunohistochemical analysis of Oct1expression in tumor specimens obtained from 102 patients with prostate cancer showed a positive correlation of Oct1immunoreactivity with a high Gleason score and AR immunoreactivity (p 5 0.0042 and p &lt; 0.0001, respectively). Moreover,patients with high immunoreactivity of Oct1 showed a low cancer-specific survival rate, and those patients with highimmunoreactivities of both Oct1 and AR exhibited poorer cancer-specific prognosis. Multivariate hazard analysis revealed asignificant correlation between high Oct1 immunoreactivity and poor cancer-specific survival (p 5 0.012). These resultsdemonstrate that Oct1 can be a prognostic factor in prostate cancer as a coregulator of AR and may lead to the developmentof a new therapeutic intervention for prostate cancer.

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