Uncommon pathogens in an immunocompetent host: respiratory isolation of Cunninghamella bertholletiae, Aspergillus niger, Staphylococcus pseudintermedius and adenovirus in a patient with necrotising pneumonia

2022 ◽  
Vol 15 (1) ◽  
pp. e240484
Author(s):  
Christian Olivo Freites ◽  
Hendrik Sy ◽  
Patricia Miguez ◽  
James Salonia
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Aspergillus Niger ◽  
Unusual Case ◽  
Chronic Obstructive ◽  
Immunocompetent Host ◽  
Staphylococcus Pseudintermedius ◽  
Obstructive Pulmonary Disease ◽  
Cunninghamella Bertholletiae

We present the unusual case of a 60-year-old immunocompetent woman with chronic obstructive pulmonary disease who developed a necrotising pneumonia with isolation of Cunninghamella bertholletiae, Aspergillus niger, Staphylococcus pseudintermedius and adenovirus. The patient recovered with antimicrobial therapy and supportive care in the intensive care unit. The current literature on diagnosis and treatment of these pathogens is reviewed.

scholarly journals Moxifloxacin in Chronic Obstructive Pulmonary Disease: Pharmacokinetics and Penetration into Bronchial Secretions in Ward and Intensive Care Unit Patients

2019 ◽  
Vol 63 (3) ◽  
Author(s):  
Maria Sionidou ◽  
Katerina Manika ◽  
Georgia Pitsiou ◽  
Paschalina Kontou ◽  
Kalliopi Chatzika ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Pulmonary Disease ◽  
Pharmacokinetic Profile ◽  
Pharmacokinetic Parameters ◽  
Chronic Obstructive ◽  
Icu Patients ◽  
Obstructive Pulmonary Disease ◽  
Bronchial Secretions

ABSTRACT This study aimed to evaluate the pharmacokinetic profile of moxifloxacin (MXF) in serum and sputum/bronchial secretions of 22 patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) hospitalized in the ward and intensive care unit (ICU). The data showed that ICU patients had lower concentrations in secretions (P = 0.01). However, no other statistically significant differences were observed in pharmacokinetic parameters and penetration in secretions between ward and ICU patients. MXF showed a favorable pharmacokinetic profile, and the pharmacodynamic targets for common pathogens for AECOPD were achieved.

scholarly journals Reversal of a Suspected Paradoxical Reaction to Zopiclone with Flumazenil

2016 ◽  
Vol 2016 ◽  
pp. 1-3
Author(s):  
Zarah Jordahn ◽  
Cheme Andersen ◽  
Anne Marie Roust Aaberg ◽  
Frank Christian Pott
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Receptor Agonist ◽  
Elderly Woman ◽  
Behavioral Changes ◽  
Chronic Obstructive ◽  
Paradoxical Reaction ◽  
Obstructive Pulmonary Disease ◽  
To Receive

We describe the care for an elderly woman who was admitted to the intensive care unit (ICU) to receive noninvasive ventilation for acute exacerbation of chronic obstructive pulmonary disease. After administration of the sleeping pill zopiclone, a nonbenzodiazepine receptor agonist (NBRA), the patient became agitated and was confused, a possible paradoxical reaction to benzodiazepines. These symptoms were immediately resolved after treatment with flumazenil, usually used to reverse the adverse effects of benzodiazepines or NBRAs and to reverse paradoxical reactions to benzodiazepines. This case indicates that zopiclone induced behavioral changes resembling a paradoxical reaction to benzodiazepines and these symptoms may be treated with flumazenil.

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