CDK4/6 inhibitor-induced colitis: a case report and review of the literature

2021 ◽  
Vol 14 (7) ◽  
pp. e242766
Author(s):  
Azhar Abbas Malik ◽  
Haider Abbas ◽  
Zin Mar Oo ◽  
Zerlene Lim
Keyword(s):  
Breast Cancer ◽  
Biopsy Specimen ◽  
Histopathological Examination ◽  
Tumour Response ◽  
Inflammatory Cells ◽  
Unanswered Question ◽  
Mechanism Of Injury ◽  
Review Of The Literature ◽  
Life Threatening ◽  
Positive Breast Cancer

A 72-year-old woman with metastatic ER/PR-positive breast cancer who had been on ribociclib and letrozole for 1 year developed severe life-threatening colitis. She presented to emergency department with features of acute abdomen and diarrhoea. The diagnosis of colitis was confirmed radiologically as well as by histopathological examination of the biopsy specimen and the patient clinically improved after withholding ribociclib and receiving corticosteroids compatible with ribociclib-induced colitis. The mechanism of injury in CDK 4/6 inhibitor-induced colitis is unknown but may be related to recruitment of inflammatory cells. Whether the development of colitis is associated with tumour response is an interesting and unanswered question.

scholarly journals Bilateral De Quervain Syndrome after Aromatase Inhibitor Administration: A Case Report and Review of the Literature

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Konstantinos Papadimitriou ◽  
Panteleimon Kountourakis ◽  
Emmanouil Morakis ◽  
Vassilios Vassiliou ◽  
Vasileios Barbounis ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Case Report ◽  
Aromatase Inhibitors ◽  
Treatment Options ◽  
Relevant Literature ◽  
Musculoskeletal Symptoms ◽  
Review Of The Literature ◽  
Hormone Receptor Positive ◽  
De Quervain ◽  
Positive Breast Cancer

Aromatase inhibitors are widely used as one of the main treatment options of both early and advanced hormone receptor-positive breast cancer in postmenopausal women. Unfortunately, musculoskeletal symptoms are often presented in patients treated with aromatase inhibitors (AIs), and, although the pathogenesis is unknown, postulated mechanisms have been described. Herein, to our knowledge, we present the first report of bilateral De Quervain syndrome related with AIs therapy with a review of the relevant literature.

Complete Response of Metastatic Androgen Receptor–Positive Breast Cancer to Bicalutamide: Case Report and Review of the Literature

2016 ◽  
Vol 34 (4) ◽  
pp. e21-e24 ◽  
Author(s):  
Claudia Arce-Salinas ◽  
Maria Carmen Riesco-Martinez ◽  
Wedad Hanna ◽  
Philippe Bedard ◽  
Ellen Warner
Keyword(s):  
Breast Cancer ◽  
Case Report ◽  
Androgen Receptor ◽  
Complete Response ◽  
Review Of The Literature ◽  
Positive Breast Cancer

scholarly journals Pemphigus herpetiformis - a case report of a rare form of pemphigus and review of the literature

2016 ◽  
Vol 73 (10) ◽  
pp. 967-972 ◽  
Author(s):  
Jelena Stojkovic-Filipovic ◽  
Branislav Lekic ◽  
Danijela Milcic ◽  
Mirjana Milinkovic
Keyword(s):  
Case Report ◽  
Clinical Remission ◽  
Therapeutic Approach ◽  
Biopsy Specimen ◽  
Clinical Presentation ◽  
Histopathological Examination ◽  
Review Of The Literature ◽  
Rare Form ◽  
Systemic Corticosteroids ◽  
Complete Clinical Remission

Introduction. Pemphigus herpetiformis is the rare variant of pemphigus with characteristic clinical features, histopathological findings different from the convectional pemphigus, and immunological findings consistent with pemphigus. Case report. We presented a 65-year-old woman with initial pruritus followed by pruritic urticarial papules and plaques, some with annular rings of tense vesicles on the periphery, on the trunk and extremities, with no mucous lesions. Histopathological examination demonstrated spongiosis and intraepidermal vesicles in the mid or subcorneal epidermis in some biopsy specimen, with neutrophil and eosinophil infiltrate. Direct immunoflorescent microscopy revealed intercellular IgG deposition, most prominent in the upper layers of epidermis. Indirect immunoflorescent microscopy showed intercellular binding of IgG autoantibodies in the patient?s sera. Initially the patient was threated with systemic corticosteroids and azathioprine, but dapson provided complete clinical remission. Conclusion. This entity was established 40 years ago, and around 100 patients have been reported worldwide. It is important to be aware of this particular form of pemphigus because clinical presentation, course of the disease and therapeutic approach are different from conventional forms of pemphigus.

scholarly journals Metastasis of Pregnancy-Associated Breast Cancer (Suspected to Be Hereditary Breast and Ovarian Cancer) to the Brain, Diagnosed at 18 Weeks’ Gestation: A Case Report and Review of the Literature

2016 ◽  
Vol 2016 ◽  
pp. 1-5
Author(s):  
Tomohiro Okuda ◽  
Sakura Yamamoto ◽  
Seiki Matsuo ◽  
Hisashi Kataoka ◽  
Jo Kitawaki
Keyword(s):  
Breast Cancer ◽  
Ovarian Cancer ◽  
Genetic Counseling ◽  
Triple Negative ◽  
Ductal Carcinoma ◽  
Histopathological Examination ◽  
Review Of The Literature ◽  
Breast And Ovarian Cancer ◽  
Her Family ◽  
The Brain

We report a case of pregnancy-associated breast cancer with metastasis to the brain, likely resulting from hereditary breast and ovarian cancer (HBOC). A 35-year-old woman (gravida 2, para 0-1-0-1) underwent a right mastectomy and right axillary dissection after a cesarean section at 30 years of age; her mother died at 47 years of age due to breast cancer. Histopathological examination indicated an invasive ductal carcinoma with triple-negative cancer (cancer stage 2B [pT3N0M0]). The patient refused adjuvant therapy because of the risk of infertility. After 4 years, she became pregnant naturally. At 18 weeks’ gestation, she experienced aphasia and dyslexia due to brain metastasis. The pregnancy was terminated at 21 weeks’ gestation after thorough counseling. Her family history, young-onset disease, and histopathological findings suggested HBOC. She declined genetic testing for BRCA1/2, though genetic counseling was provided. In cases of pregnancy-related breast cancer, consideration must be given to whether the pregnancy should be continued and to posttreatment fertility. HBOC should also be considered. Genetic counseling should be provided and the patient should be checked for theBRCAmutation, as it is meaningful for the future of any potential children. Genetic counseling should be provided even if the cancer is advanced or recurrent.

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