Morphological characteristics of parapapillary atrophy and subsequent visual field progression in primary open-angle glaucoma

2020 ◽  
pp. bjophthalmol-2019-315477 ◽  
Author(s):  
Ahnul Ha ◽  
Yong Woo Kim ◽  
Jinho Lee ◽  
Eunoo Bak ◽  
Young Soo Han ◽  
...  
Keyword(s):  
Visual Field ◽  
Optic Disc ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Morphological Characteristics ◽  
Rank Test ◽  
Cumulative Probability ◽  
Open Angle ◽  
Irregularity Index ◽  
Parapapillary Atrophy

Background/AimsTo investigate the associations between the morphological characteristics of beta-zone parapapillary atrophy (β-zone PPA) and subsequent visual field (VF) progression in eyes with primary open-angle glaucoma (POAG).MethodsOne hundred and twenty-one POAG eyes with β-zone PPA along with 48 normal eyes with β-zone PPA were included. β-zone PPA area was calculated based on the PPA pixel area/optic-disc pixel area ratio and the optical coherence tomography (OCT)-measured disc area. β-zone PPA margin irregularity was quantified as a function of both area (A) and perimeter (P, calculated as 1/(4πA/P²)). VF progression was defined using standard automated perimetry’s guided progression analysis software.ResultsOf the 121 POAG eyes, 49 (40.5%) showed VF progression during the 10.1±1.9 years of follow-up. The baseline β-zone PPA area was similar among the three groups (Progressors, Non-progressors and Controls, p=0.995). However, the β-zone PPA irregularity index was significantly higher in the Progressors (p<0.001). The cumulative probability of VF progression was greater in the higher PPA irregularity index group (p<0.001, log-rank test). A Cox proportional hazards model showed the significant influences of optic disc haemorrhage (HR: 2.661, p=0.034) and higher baseline PPA irregularity index (HR: 1.455, p=0.007) on subsequent progression.ConclusionsIn POAG eyes, baseline β-zone PPA margin regularity was significantly associated with subsequent VF progression. Irregular margin of β-zone PPA might be the mark of vulnerability in the parapapillary area to further glaucomatous damage.

scholarly journals Visual field indices and optic disc parameters in a 24-month follow-up of primary open angle glaucoma patients

1999 ◽  
Vol 77 (S229) ◽  
pp. 20-21
Author(s):  
Angelo Macrì ◽  
Maurizio Rolando ◽  
Guido Corallo ◽  
Michele Iester ◽  
Giuseppe Verrastro ◽  
...  
Keyword(s):  
Visual Field ◽  
Optic Disc ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Visual Field Indices

Relationship between parapapillary atrophy and visual field abnormality in primary open-angle glaucoma

1999 ◽  
Vol 127 (6) ◽  
pp. 674-680 ◽  
Author(s):  
Yoshiki Kono ◽  
Linda Zangwill ◽  
Pamela A Sample ◽  
Jost B Jonas ◽  
Alireza Emdadi ◽  
...  
Keyword(s):  
Visual Field ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Parapapillary Atrophy

scholarly journals A comparative study of computerised visual field testing and optic disc morphometric parameters in the follow-up of primary open angle glaucoma

Eye ◽  
1998 ◽  
Vol 12 (6) ◽  
pp. 916-920 ◽  
Author(s):  
Angelo Macri ◽  
Maurizio Rolando ◽  
Guido Corallo ◽  
Michele Iester ◽  
Giuseppe Verrastro ◽  
...  
Keyword(s):  
Visual Field ◽  
Comparative Study ◽  
Optic Disc ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Field Testing ◽  
Morphometric Parameters ◽  
Open Angle ◽  
Visual Field Testing

scholarly journals Morning glory syndrome associated with primary open angle glaucoma: Case report

2014 ◽  
Vol 142 (3-4) ◽  
pp. 223-225 ◽  
Author(s):  
Marija Bozic ◽  
Paraskeva Hentova-Sencanic ◽  
Vujica Markovic ◽  
Ivan Marjanovic
Keyword(s):  
Visual Field ◽  
Optic Disc ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Field Testing ◽  
Morning Glory ◽  
Diagnostic Tools ◽  
Visual Field Defects ◽  
Open Angle ◽  
Morning Glory Syndrome

Introduction. Morning glory syndrome (MGS) is a rare congenital optic disc anomaly, first reported in 1970. MGS is a nonprogressive and untreatable condition, which usually occurs as an isolated ocular anomaly, and can be associated with the increased incidence of nonrhegmatogenous retinal detachment, and also with strabismus, afferent pupillary defect, visual field defects, presence of hyaloids artery remnants, ciliary body cyst, congenital cataract, lid hemangioma and preretinal gliosis. Case Outline. We report a clinical case of MGS associated with primary open angle glaucoma. The use of sophisticated diagnostic tools, such as retinal tomography and visual field testing is limited if multiple eye conditions are present, since optic disc does not have ?usual? appearance that can be analyzed according to standard statistical databases. Conclusion. In treating and follow up of glaucoma cases associated with other diseases and conditions that affect the appearance and function of the optic nerve head, sometimes the use of modern technological methods is limited due to difficult interpretation of the obtained results.

scholarly journals Characteristics of Optic Disc and Visual Field Changes in Patients with Thyroid-Associated Orbitopathy and Open-Angle Glaucoma

2021 ◽  
Vol 10 (17) ◽  
pp. 3839
Author(s):  
Chih-Kang Hsu ◽  
Hsin-Yu Yao ◽  
Che-Min Lin ◽  
Hsu-Chieh Chang ◽  
Da-Wen Lu ◽  
...  
Keyword(s):  
Visual Field ◽  
Nerve Fiber ◽  
Optic Disc ◽  
Medical Records ◽  
Fiber Bundle ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Fiber Layer ◽  
Parapapillary Atrophy

This study aimed to characterize the changes in the visual field (VF) patterns and disc morphology of patients with thyroid-associated orbitopathy (TAO) and open-angle glaucoma (OAG). A retrospective review of the medical records at the Tri-Service General Hospital in Taiwan identified 396 eyes of 198 patients with thyroid-associated glaucoma. A final follow-up of VF examination in 140 eyes revealed 114 eyes with VF defects, indicating disease progression. The characteristics of and changes in disc morphology, optical coherence tomography findings, and VF defects were statistically analyzed. The most common VF defects at the initial diagnosis and the end of the follow-up period were inferior partial arcuate (17%) and paracentral (15%) defects, respectively. The most common VF defect in patients with unspecific disc signs was an unspecific scotoma (13%). The most common optic disc feature was disc cupping (51%), followed by parapapillary atrophy (48%). The most frequent location of nerve fiber layer thinning was the inferotemporal region (48%). VF defects showed a significantly more pronounced progression in the non-nerve fiber bundle group than in the nerve fiber bundle group (p < 0.001). This study details the characteristics and progression of disc morphology and VF defects in patients with TAO and OAG.

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