Characteristics of Optic Disc and Visual Field Changes in Patients with Thyroid-Associated Orbitopathy and Open-Angle Glaucoma

This study aimed to characterize the changes in the visual field (VF) patterns and disc morphology of patients with thyroid-associated orbitopathy (TAO) and open-angle glaucoma (OAG). A retrospective review of the medical records at the Tri-Service General Hospital in Taiwan identified 396 eyes of 198 patients with thyroid-associated glaucoma. A final follow-up of VF examination in 140 eyes revealed 114 eyes with VF defects, indicating disease progression. The characteristics of and changes in disc morphology, optical coherence tomography findings, and VF defects were statistically analyzed. The most common VF defects at the initial diagnosis and the end of the follow-up period were inferior partial arcuate (17%) and paracentral (15%) defects, respectively. The most common VF defect in patients with unspecific disc signs was an unspecific scotoma (13%). The most common optic disc feature was disc cupping (51%), followed by parapapillary atrophy (48%). The most frequent location of nerve fiber layer thinning was the inferotemporal region (48%). VF defects showed a significantly more pronounced progression in the non-nerve fiber bundle group than in the nerve fiber bundle group (p < 0.001). This study details the characteristics and progression of disc morphology and VF defects in patients with TAO and OAG.

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Study of correlation of retinal nerve fiber layer thickness and optic disc parameters with visual field changes in glaucoma suspects and diagnosed cases of primary open angle glaucoma

MedPulse International Journal of Ophthalmology ◽

10.26611/1009913 ◽

2019 ◽

Vol 9 (1) ◽

pp. 10-13

Author(s):

Latha C ◽

◽

Praveen Kumar G S ◽

Keyword(s):

Visual Field ◽

Nerve Fiber ◽

Layer Thickness ◽

Optic Disc ◽

Retinal Nerve Fiber Layer ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Open Angle ◽

Fiber Layer ◽

Nerve Fiber Layer Thickness

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Visual field indices and optic disc parameters in a 24-month follow-up of primary open angle glaucoma patients

Acta Ophthalmologica Scandinavica ◽

10.1111/j.1600-0420.1999.tb01128.x ◽

1999 ◽

Vol 77 (S229) ◽

pp. 20-21

Author(s):

Angelo Macrì ◽

Maurizio Rolando ◽

Guido Corallo ◽

Michele Iester ◽

Giuseppe Verrastro ◽

...

Keyword(s):

Visual Field ◽

Optic Disc ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Open Angle ◽

Visual Field Indices

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Baseline structural characteristics of the optic nerve head and retinal nerve fiber layer are associated with progressive visual field loss in patients with open-angle glaucoma

PLoS ONE ◽

10.1371/journal.pone.0236819 ◽

2020 ◽

Vol 15 (8) ◽

pp. e0236819

Author(s):

Brent Siesky ◽

Scott M. Wentz ◽

Ingrida Januleviciene ◽

Daniel H. Kim ◽

Kendall M. Burgett ◽

...

Keyword(s):

Optic Nerve ◽

Visual Field ◽

Nerve Fiber ◽

Retinal Nerve Fiber Layer ◽

Optic Nerve Head ◽

Open Angle Glaucoma ◽

Structural Characteristics ◽

Visual Field Loss ◽

Open Angle ◽

Fiber Layer

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Faculty Opinions recommendation of Structural characteristics of the acquired optic disc pit and the rate of progressive retinal nerve fiber layer thinning in primary open-angle glaucoma.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726116217.793514069 ◽

2016 ◽

Author(s):

Christopher Leung

Keyword(s):

Nerve Fiber ◽

Optic Disc ◽

Retinal Nerve Fiber Layer ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Structural Characteristics ◽

Open Angle ◽

Optic Disc Pit ◽

Fiber Layer ◽

Nerve Fiber Layer

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Retinal Nerve Fiber Layer Thickness in Relation to Optic Disc Cup Shape in Open-Angle Glaucoma

Glaucoma Update IV ◽

10.1007/978-3-642-76084-6_14 ◽

1991 ◽

pp. 103-108 ◽

Cited By ~ 2

Author(s):

B. Schwartz ◽

T. Takamoto

Keyword(s):

Nerve Fiber ◽

Layer Thickness ◽

Optic Disc ◽

Retinal Nerve Fiber Layer ◽

Open Angle Glaucoma ◽

Open Angle ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Nerve Fiber Layer Thickness ◽

Retinal Nerve Fiber

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Optic Disc Topography and Peripapillary Retinal Nerve Fiber Layer Thickness in Nonarteritic Ischemic Optic Neuropathy and Open-Angle Glaucoma

Ophthalmology ◽

10.1016/j.ophtha.2006.01.072 ◽

2006 ◽

Vol 113 (8) ◽

pp. 1340-1344 ◽

Cited By ~ 25

Author(s):

Hitomi Saito ◽

Atsuo Tomidokoro ◽

Eiichiro Sugimoto ◽

Makoto Aihara ◽

Goji Tomita ◽

...

Keyword(s):

Nerve Fiber ◽

Layer Thickness ◽

Optic Disc ◽

Optic Neuropathy ◽

Retinal Nerve Fiber Layer ◽

Open Angle Glaucoma ◽

Ischemic Optic Neuropathy ◽

Open Angle ◽

Fiber Layer ◽

Nerve Fiber Layer Thickness

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Morphological characteristics of parapapillary atrophy and subsequent visual field progression in primary open-angle glaucoma

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2019-315477 ◽

2020 ◽

pp. bjophthalmol-2019-315477 ◽

Cited By ~ 1

Author(s):

Ahnul Ha ◽

Yong Woo Kim ◽

Jinho Lee ◽

Eunoo Bak ◽

Young Soo Han ◽

...

Keyword(s):

Visual Field ◽

Optic Disc ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Morphological Characteristics ◽

Rank Test ◽

Cumulative Probability ◽

Open Angle ◽

Irregularity Index ◽

Parapapillary Atrophy

Background/AimsTo investigate the associations between the morphological characteristics of beta-zone parapapillary atrophy (β-zone PPA) and subsequent visual field (VF) progression in eyes with primary open-angle glaucoma (POAG).MethodsOne hundred and twenty-one POAG eyes with β-zone PPA along with 48 normal eyes with β-zone PPA were included. β-zone PPA area was calculated based on the PPA pixel area/optic-disc pixel area ratio and the optical coherence tomography (OCT)-measured disc area. β-zone PPA margin irregularity was quantified as a function of both area (A) and perimeter (P, calculated as 1/(4πA/P²)). VF progression was defined using standard automated perimetry’s guided progression analysis software.ResultsOf the 121 POAG eyes, 49 (40.5%) showed VF progression during the 10.1±1.9 years of follow-up. The baseline β-zone PPA area was similar among the three groups (Progressors, Non-progressors and Controls, p=0.995). However, the β-zone PPA irregularity index was significantly higher in the Progressors (p<0.001). The cumulative probability of VF progression was greater in the higher PPA irregularity index group (p<0.001, log-rank test). A Cox proportional hazards model showed the significant influences of optic disc haemorrhage (HR: 2.661, p=0.034) and higher baseline PPA irregularity index (HR: 1.455, p=0.007) on subsequent progression.ConclusionsIn POAG eyes, baseline β-zone PPA margin regularity was significantly associated with subsequent VF progression. Irregular margin of β-zone PPA might be the mark of vulnerability in the parapapillary area to further glaucomatous damage.

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