Increased risk of irritable bowel syndrome after bacterial gastroenteritis: cohort study

Background: The association between Helicobacter pylori (H. pylori) infection and the risk of developing irritable bowel syndrome (IBS) has yet to be investigated; thus, we conducted this nationwide cohort study to examine the association in patients from Taiwan. Methods: A total of approximately 2669 individuals with newly diagnosed H. pylori infection and 10,676 age- and sex-matched patients without a diagnosis of H. pylori infection from 2000 to 2013 were identified from Taiwan’s National Health Insurance Research Database. The Kaplan–Meier method was used to determine the cumulative incidence of H. pylori infection in each cohort. Whether the patient underwent H. pylori eradication therapy was also determined. Results: The cumulative incidence of IBS was higher in the H. pylori-infected cohort than in the comparison cohort (log-rank test, p < 0.001). After adjustment for potential confounders, H. pylori infection was associated with a significantly increased risk of IBS (adjusted hazard ratio (aHR) 3.108, p < 0.001). In addition, the H. pylori-infected cohort who did not receive eradication therapy had a higher risk of IBS than the non-H. pylori-infected cohort (adjusted HR 4.16, p < 0.001). The H. pylori-infected cohort who received eradication therapy had a lower risk of IBS than the comparison cohort (adjusted HR 0.464, p = 0.037). Conclusions: Based on a retrospective follow-up, nationwide study in Taiwan, H. pylori infection was associated with an increased risk of IBS; however, aggressive H. pylori infection eradication therapy can also reduce the risk of IBS. Further underlying biological mechanistic research is needed.

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Biliary events and an increased risk of new onset irritable bowel syndrome: a population-based cohort study

Alimentary Pharmacology & Therapeutics ◽

10.1111/j.1365-2036.2008.03715.x ◽

2008 ◽

Vol 28 (3) ◽

pp. 334-343 ◽

Cited By ~ 11

Author(s):

M. A. MCNALLY ◽

G. R. LOCKE ◽

A. R. ZINSMEISTER ◽

C. D. SCHLECK ◽

J. PETERSON ◽

...

Keyword(s):

Irritable Bowel Syndrome ◽

Cohort Study ◽

Population Based ◽

Increased Risk ◽

Irritable Bowel ◽

New Onset

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W1321 Famine in Early Life Is Associated with An Increased Risk of Developing Irritable Bowel Syndrome, a Population Based Cohort Study

Gastroenterology ◽

10.1016/s0016-5085(08)63172-8 ◽

2008 ◽

Vol 134 (4) ◽

pp. A-679-A-680

Author(s):

Tamira K. Klooker ◽

Breg Braak ◽

Rebecca C. Painter ◽

Susanne R.R. de Rooij ◽

Ruurd M. van Elburg ◽

...

Keyword(s):

Irritable Bowel Syndrome ◽

Cohort Study ◽

Early Life ◽

Population Based ◽

Increased Risk ◽

Irritable Bowel

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Irritable Bowel Syndrome and Risk of Parkinson’s Disease in Finland: A Nationwide Registry-Based Cohort Study

Journal of Parkinson s Disease ◽

10.3233/jpd-202330 ◽

2021 ◽

pp. 1-11

Author(s):

Tuomas H. Mertsalmi ◽

Anna But ◽

Eero Pekkonen ◽

Filip Scheperjans

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Irritable Bowel Syndrome ◽

Cohort Study ◽

Proportional Hazards Model ◽

Cox Model ◽

Cox Proportional Hazards Model ◽

Prodromal Symptom ◽

Increased Risk ◽

Irritable Bowel

Background: The gastrointestinal tract is considered as a potential origin of Parkinson’s disease (PD) pathology. Besides constipation, appendectomy and inflammatory bowel disease have also been associated with a higher PD-risk, but findings have been inconsistent. To date, there is only one previous study suggesting that irritable bowel syndrome (IBS) is associated with an increased risk of PD. Objective: To evaluate whether IBS is associated with a higher risk of PD. Methods: In this retrospective registry-based cohort study, we identified 28,150 patients that were diagnosed with IBS (IBS+) during the years 1998–2014, using data from the Finnish Care Register for Health Care. In addition, 98,789 IBS-free reference subjects (IBS-) of same age and gender and living in the same municipality were included. The study subjects were followed until the end of the year 2014 to analyze the incidence of PD. The association between IBS and PD was assessed by a Cox proportional hazards model. Results: Diagnosis of IBS was associated with a higher hazard of PD with an adjusted hazard ratio (aHR) of 1.70 (95% CI 1.27–2.26). However, the ratio of hazard rates for PD between IBS+ and IBS- subjects was not constant over time. The Cox model with time-varying coefficient for IBS status showed that the hazard of PD was significantly higher in IBS patients only during the first two years of follow-up (aHR 2.96, 95% CI 1.78–4.92). Conclusion: Our findings indicate that the association between IBS and PD is likely explained by reverse causation and detection bias. It remains open whether IBS is an actual risk factor or a prodromal symptom of PD.

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Faculty Opinions recommendation of Irritable bowel syndrome and chronic fatigue 3 years after acute giardiasis: historic cohort study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13276963.14837054 ◽

2012 ◽

Author(s):

Guido Basilisco

Keyword(s):

Irritable Bowel Syndrome ◽

Cohort Study ◽

Chronic Fatigue ◽

Irritable Bowel ◽

Historic Cohort

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Faculty Opinions recommendation of Change in Quality of Life for Patients with Irritable Bowel Syndrome following Referral to a Gastroenterologist: A Cohort Study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725823923.793510255 ◽

2015 ◽

Author(s):

Adam Farmer

Keyword(s):

Quality Of Life ◽

Irritable Bowel Syndrome ◽

Cohort Study ◽

Irritable Bowel

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Irritable bowel syndrome and Parkinson’s disease risk: register-based studies

npj Parkinson s Disease ◽

10.1038/s41531-020-00145-8 ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Bojing Liu ◽

Arvid Sjölander ◽

Nancy L. Pedersen ◽

Jonas F. Ludvigsson ◽

Honglei Chen ◽

...

Keyword(s):

Parkinson’S Disease ◽

Irritable Bowel Syndrome ◽

Case Control Study ◽

Case Control ◽

Twin Registry ◽

Increased Risk ◽

Irritable Bowel ◽

Nested Case Control ◽

Control Study ◽

Swedish Twin Registry

AbstractTo examine whether irritable bowel syndrome (IBS) was related to the future risk of Parkinson’s disease (PD), we conducted a nested case-control study in the Swedish total population including 56,564 PD cases identified from the Swedish Patient Register and 30 controls per case individually matched by sex and year of birth. Odds ratios (ORs) with 95% confidence intervals (CIs) for having a prior diagnosis of IBS were estimated using conditional logistic regression. We furthermore conducted a cohort study using the Swedish Twin Registry following 3046 IBS patients identified by self-reported abdominal symptoms and 41,179 non-IBS individuals. Through Cox proportional hazard models, we estimated hazard ratios (HRs) and 95% CIs for PD risk. In the nested case-control study, 253 (0.4%) PD cases and 5204 (0.3%) controls had a previous IBS diagnosis. IBS diagnosis was associated with a 44% higher risk of PD (OR = 1.44, 95% CI 1.27–1.63). Temporal relationship analyses showed 53% and 38% increased risk of PD more than 5 and 10 years after IBS diagnosis, respectively. In the cohort analysis based on the Swedish Twin Registry, there was no statistically significantly increased risk of PD related to IBS (HR = 1.25, 95% CI = 0.87–1.81). Our results suggest a higher risk of PD diagnosis after IBS. These results provide additional evidence supporting the importance of the gut–brain axis in PD.

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Risks of Major Mental Disorders and Irritable Bowel Syndrome among the Offspring of Parents with Irritable Bowel Syndrome: A Nationwide Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18094679 ◽

2021 ◽

Vol 18 (9) ◽

pp. 4679

Author(s):

Ta-Chuan Yeh ◽

Ya-Mei Bai ◽

Shih-Jen Tsai ◽

Tzeng-Ji Chen ◽

Chih-Sung Liang ◽

...

Keyword(s):

Irritable Bowel Syndrome ◽

Mental Disorders ◽

Autism Spectrum ◽

Cross Sectional Survey ◽

Cross Sectional ◽

Logistic Regression Models ◽

Early Implementation ◽

Increased Risk ◽

Nationally Representative ◽

Irritable Bowel

Irritable bowel syndrome (IBS) is a functional bowel disorder that is highly comorbid with mental disorders. However, few studies have examined the risk of attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder, major depressive disorder (MDD), and schizophrenia in the offspring of parents with IBS. We used nationally representative cross-sectional survey data to analyze cross-generational transmission patterns of both IBS and major mental disorders. Odds ratio (OR) was calculated by using logistic regression models with adjustment for potential confounding factors. Offspring of parents with IBS were more likely to develop IBS themselves (OR = 2.41, 95% confidence interval (CI), 2.09–2.78), ADHD (OR = 1.33, 95% CI, 1.08–1.62), and MDD (OR = 1.32, 95% CI, 1.04–1.68) than the controls. Data stratification by parental sex revealed that paternal IBS increased risk of ADHD (OR = 1.34, 95% CI, 1.01–1.77) in the offspring, while maternal IBS increased the risk of MDD (OR = 1.51, 95% CI, 1.11–2.06). This is the first study to reveal parental IBS is associated with IBS, ADHD, and MDD among offspring, suggesting the necessity for early implementation of prevention strategies for at-risk children.

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