GSK recalls ranitidine products over potential carcinogen contamination

BMJ ◽  
2019 ◽  
pp. l5933 ◽  
Author(s):  
Elisabeth Mahase
Keyword(s):  
Potential Carcinogen

scholarly journals Genotoxicity Study on Nicotine and Nicotine-Derived Nitrosamine by Accelerator Mass Spectrometry

Radiocarbon ◽  
1996 ◽  
Vol 38 (2) ◽  
pp. 347-353 ◽  
Author(s):  
X. S. Li ◽  
H. F. Wang ◽  
J. Y. Shi ◽  
X. Y. Wang ◽  
Y. F. Liu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Dna Adducts ◽  
Accelerator Mass Spectrometry ◽  
Chemical Speciation ◽  
Animal Experiments ◽  
Tobacco Consumption ◽  
Carcinogenic Risk ◽  
Dna Adduction ◽  
Carcinogenic Risk Assessment ◽  
Potential Carcinogen

We have studied DNA adduction with 14C-labeled nicotine and nicotine-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), by accelerator mass spectrometry (AMS) in mouse liver at doses equivalent to low-level exposure of humans. The dose ranges of nicotine and NNK administered were from 0.4 μg to 4.0×102 μg kg b.w.-1, and from 0.1 μg to 2.0×104 μg kg b.w.-1, respectively. In the exposure of mice to either nicotine or NNK, the number of DNA adducts increased linearly with increasing dose. The detection limit of DNA adducts was 1 adduct per 1011 nucleotide molecules. This limit is 1–4 orders of magnitude lower than that of other techniques used for quantification of DNA adducts. The results of our animal experiments enabled us to speculate that nicotine is a potential carcinogen. According to the procedure for 14C-labeled-NNK synthesis, we discuss the ultimate chemical speciation of NNK bound to DNA. From the animal tests we derived a directly perceivable relation between tobacco consumption and DNA adduction as the carcinogenic risk assessment.

scholarly journals In Vitro Evaluation of Coating Performance of Guidewire Surrogates

2017 ◽  
Author(s):  
Huiyu Shi ◽  
Katherine Vorvolakos ◽  
Maureen Dreher ◽  
Donna Walsh ◽  
Nandini Duraiswamy
Keyword(s):  
Environmental Protection Agency ◽  
Stress Tests ◽  
Protection Agency ◽  
Serious Adverse Events ◽  
Coating Performance ◽  
Special Concern ◽  
Intravascular Catheters ◽  
Phase Out ◽  
Potential Carcinogen

Vascular guidewires are commonly used during interventional surgery to help introduce and position intravascular catheters at the treatment site. Nitinol (NiTi) and stainless steel are the most commonly used alloys in guidewires and a thin layer of polymer coating is usually applied on the guidewire surface to reduce friction within the lumen of blood vessels. Hydrophobic (e.g. PTFE) or hydrophilic (e.g., hyaluronic acid (HA), polyvinylpyrrolidone (PVP), etc.) coatings may be used for this purpose, but coating separation/flaking has been reported from intravascular medical devices [1]. Coating fragments may cause serious adverse events in patients, including pulmonary embolism and infarction, myocardial embolism, necrosis, and death. Hydrophilic polymer emboli in patients has also been reported [2][3][4]. By 2015, the Environmental Protection Agency (EPA) required device manufacturers to phase out the use of the surfactant, perfluorooctanoic acid (PFOA), a potential carcinogen during polytetrafluoroethylene (PTFE) coating manufacturing [5]. Such changes in manufacturing processes need to be evaluated for their effects on coating performance. Of special concern is flaking of coatings, a multifactorial phenomenon that may be related to changes in device design, manufacturing, pre-conditioning, storage, and/or clinical use. There is no comprehensive standard for assessment of coating performance on guidewires. The objective of this study was to evaluate hydrophilic coating integrity and durability during in vitro soaking and bending stress tests.

scholarly journals Spot the potential carcinogen

Nature ◽  
1982 ◽  
Vol 296 (5852) ◽  
pp. 100-100
Author(s):  
Alastair Hay
Keyword(s):  
Potential Carcinogen

Benzo(a)pyrene Content of Smoked and Smoke-Flavored Cheese Products Sold in Wisconsin

1992 ◽  
Vol 55 (8) ◽  
pp. 636-638 ◽  
Author(s):  
WILLIAM E. RIHA ◽  
WILLIAM L. WENDORFF ◽  
SUE RANK
Keyword(s):  
Retail Market ◽  
Liquid Smoke ◽  
Wide Range ◽  
Cheese Products ◽  
Potential Carcinogen

A survey was conducted in southern Wisconsin to determine the 3,4-benzo(a)pyrene content of smoked and smoke-flavored cheese products in the retail market. Samples included Cheddar and Swiss cheeses smoked with either natural vaporous smoke or liquid smoke flavorings. Smoke deposition measured by the color dimensions of the smoked cheese surface showed a wide range of smoke treatments among the samples. Benzo(a)pyrene was not detected in any of the cheese samples at a method sensitivity of 0.1 ppb. Current commercial smoking practices for cheese products appear effective in controlling deposition of the potential carcinogen, 3,4-benzo(a)pyrene, from the smoking process.

scholarly journals QUANTITATIVE ESTIMATION OF MAGNESIUM CARBONATE IN PAN MASALA AND GUTKA

2018 ◽  
Vol 10 (5) ◽  
pp. 32
Author(s):  
Pandey Priyambada ◽  
Goyal Anju
Keyword(s):  
Quantitative Estimation ◽  
Magnesium Carbonate ◽  
Water Soluble ◽  
Soluble Extract ◽  
Eriochrome Black T ◽  
Water Soluble Extract ◽  
Simple Economic ◽  
Potential Carcinogen ◽  
Rotary Shaker

Objective: The objective of present study is to detect and quantitatively estimate Magnesium Carbonate, a potential carcinogen used for its anti-caking property in various brands of Pan Masala and Gutka by the simple, economic and effective method.Methods: The water-soluble extract of various brands of Pan Masala and Gutka was prepared by a wrist action rotary shaker for 60 min. The extract was filtered, and the filtrate was titrated against 0.1N EDTA using Eriochrome Black T indicator at pH 10 and using Murexide indicator at pH 12.Results: The presence of Magnesium Carbonate was found to be less than 2% in all brands of Pan Masala and less than 3% in all brands of Gutka samples used in the analysis.Conclusion: There is Magnesium Carbonate used in all brands of Pan Masala and Gutka used in the present study.

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