scholarly journals Systematic literature review on which maternal alcohol behaviours are related to fetal alcohol spectrum disorders (FASD)

BMJ Open ◽  
2018 ◽  
Vol 8 (12) ◽  
pp. e022578 ◽  
Author(s):  
Sylvia Roozen ◽  
Gjalt-Jorn Ygram Peters ◽  
Gerjo Kok ◽  
David Townend ◽  
Jan Nijhuis ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Literature Review ◽  
Fetal Alcohol Spectrum Disorders ◽  
Drinking Behaviour ◽  
Fetal Alcohol ◽  
Maternal Alcohol ◽  
Maternal Alcohol Consumption ◽  
Spectrum Disorders ◽  
Fetal Alcohol Spectrum ◽  
Substantial Heterogeneity

ObjectivesFetal alcohol spectrum disorders (FASD) is a worldwide problem. Maternal alcohol consumption is an important risk factor for FASD. It remains unknown which alcohol consumption patterns most strongly predict FASD. The objective of this study was to identify these.DesignSystematic literature review.MethodsWe searched in PubMed, PsychINFO, PsycARTICLES, ERIC, CINAHL, Embase and MEDLINE up to August 2018. The query consisted of keywords and their synonyms related to FASD, pregnancy and behaviour. Studies were excluded when not published in English, were reviews or involved non-human subjects. Substantial heterogeneity precluded aggregation or meta-analysis of the data. Instead, data were qualitatively inspected.ResultsIn total, 21 studies were eligible for further data analysis. All studies that measured both maternal alcohol drinking behaviours and FASD reported retrospective data on maternal drinking patterns, employing both continuous and categorical measures and exhibiting substantial heterogeneity in measures of alcohol consumption (eg, timing of exposure, quantification of alcohol measure and definition of a standard drink). Study quality improved over time and appeared higher for studies based on active case ascertainment, especially when conducted in schools and when behaviour was assessed through interviews.ConclusionsWe aimed to identify specific maternal drinking behaviour(s) related to FASD. The state of the literature precludes such conclusions. Evidence-based preventive measures necessitate identifying which prenatal alcohol drinking behaviour(s) are most in need of intervention. Therefore, we formulate three recommendations for future research. First, future studies can optimise the value of the collected dataset through specifying measurements and reporting of maternal drinking behaviours and avoiding categorised measures (nominal or ordinal) whenever possible. Second, samples should not be selected based on FASD status, but instead, FASD status as well as maternal alcohol consumption should both be measured in a general population sample. Finally, we provide 10 reporting guidelines for FASD research.

scholarly journals Systematic literature review on which maternal alcohol behaviors are related to Fetal Alcohol Spectrum Disorders

2018 ◽  
Author(s):  
Sylvia Roozen ◽  
Gjalt - Jorn Ygram Peters ◽  
Gerjo Kok ◽  
David Townend ◽  
Jan Nijhuis ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Fetal Alcohol Spectrum Disorders ◽  
Drinking Behavior ◽  
Fetal Alcohol ◽  
Maternal Alcohol ◽  
Maternal Alcohol Consumption ◽  
Drinking Behaviors ◽  
Spectrum Disorders ◽  
Fetal Alcohol Spectrum ◽  
Substantial Heterogeneity

Objectives: Fetal Alcohol Spectrum Disorders (FASD) is a worldwide problem. Maternal alcohol consumption is an important risk factor for FASD. It remains unknown which alcohol consumption patterns most strongly predict FASD. The objective of this study was to identify these.Design: Systematic literature review.Methods: We searched in PubMed, PsychINFO, PsycARTICLES, ERIC, CINAHL, EMBASE and MEDLINE upto August 2018. The query consisted of keywords and their synonyms related to FASD, pregnancy, and behavior. Studies were excluded when not published in English, were reviews, or involved non-human subjects. Substantial heterogeneity precluded aggregation or meta-analysis of the data. Instead, data were qualitatively inspected.Results: In total, 21 studies were eligible for further data analysis. All studies that measured both maternal alcohol drinking behaviors and FASD reported retrospective data on maternal drinking patterns, employing both continuous and categorical measures and exhibiting substantial heterogeneity in measures of alcohol consumption (e.g., timing of exposure, quantification of alcohol measure,definition of a standard drink). Study quality improved over time and appeared higher for studies based on active case ascertainment, especially when conducted in schools, and when behavior was assessed through interviews.Conclusions: We aimed to identify specific maternal drinking behavior(s) related to FASD. The state ofthe literature precludes such conclusions. Evidence-based preventive measures necessitate identifying which prenatal alcohol drinking behavior(s) are most in need of intervention. Therefore, we formulate three recommendations for future research. First, future studies can optimize the value of the collected dataset through specifying measurements and reporting of maternal drinking behaviors, and avoiding categorized measures (nominal or ordinal) whenever possible. Second, samples should not be selected based on FASD status, but instead, FASD status as well as maternal alcohol consumption should both be measured in a general population sample. Finally, we provide ten reporting guidelines for FASD research.

scholarly journals Vascular effects of maternal alcohol consumption

2012 ◽  
Vol 303 (4) ◽  
pp. H414-H421 ◽  
Author(s):  
Jayanth Ramadoss ◽  
Ronald R. Magness
Keyword(s):  
Alcohol Consumption ◽  
Vascular Reactivity ◽  
Fetal Alcohol Spectrum Disorders ◽  
Vascular System ◽  
Fetal Alcohol ◽  
Paracrine Factors ◽  
Maternal Alcohol ◽  
Maternal Alcohol Consumption ◽  
Spectrum Disorders ◽  
Fetal Alcohol Spectrum

Maternal alcohol consumption during pregnancy is a significant field of scientific exploration primarily because of its negative effects on the developing fetus, which is specifically defined as fetal alcohol spectrum disorders. Though the effects on the mother are less explored compared with those on the fetus, alcohol produces multiple effects on the maternal vascular system. Alcohol has major effects on systemic hemodynamic variables, endocrine axes, and paracrine factors regulating vascular resistance, as well as vascular reactivity. Alcohol is also reported to have significant effects on the reproductive vasculature including alterations in blood flow, vessel remodeling, and angiogenesis. Data presented in this review will illustrate the importance of the maternal vasculature in the pathogenesis of fetal alcohol spectrum disorders and that more studies are warranted in this field.

scholarly journals Maternal alcohol consumption producing fetal alcohol spectrum disorders (FASD): Quantity, frequency, and timing of drinking

2013 ◽  
Vol 133 (2) ◽  
pp. 502-512 ◽  
Author(s):  
Philip A. May ◽  
Jason Blankenship ◽  
Anna-Susan Marais ◽  
J. Phillip Gossage ◽  
Wendy O. Kalberg ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Fetal Alcohol Spectrum Disorders ◽  
Fetal Alcohol ◽  
Maternal Alcohol ◽  
Maternal Alcohol Consumption ◽  
Spectrum Disorders ◽  
Fetal Alcohol Spectrum

Knowing, Valuing and Acting: Relationships between information, attitudes and drinking during pregnancy / Saber, Valorar y Actuar: Relaciones entre información, actitudes y consumo de alcohol durante la gestación

2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Mariana Beatriz López
Keyword(s):  
Alcohol Consumption ◽  
Fetal Alcohol Spectrum Disorders ◽  
Accurate Information ◽  
Source Information ◽  
Structured Interviews ◽  
Fetal Alcohol ◽  
Spectrum Disorders ◽  
Las Mujeres ◽  
The Relationship ◽  
Fetal Alcohol Spectrum

El consumo de alcohol durante la gestación puede dar lugar a distintos problemas de diferentes niveles de severidad, englobados en la expresión Trastornos del Espectro Alcohólico Fetal. Hasta el momento no ha podido determinarse una dosis de alcohol segura durante la gestación, por lo cual la recomendación de distintos organismos nacionales e internacionales es la abstinencia. Sin embargo, la evidencia señala que aunque muchas mujeres tiene conocimiento de que el alcohol puede alterar el desarrollo del feto, la mayoría piensa que algún consumo durante la gestación es aceptable. A través de este estudio buscamos contribuir a la comprensión de las relaciones entre información, actitudes y consumo durante la gestación. Para ello, analizamos entrevistas semiestructuradas realizadas a mujeres puérperas en Argentina (n=641). El 70,4% de las mujeres manifestó haber recibido alguna información sobre un potencial efecto adverso del consumo de alcohol durante la gestación, pero pocas de ellas poseían información precisa y sólo el 6,1% mencionó a un profesional de la salud como fuente. La información y las actitudes se encontraron fuertemente vinculadas. Las actitudes se asociaron de modo significativo al consumo de alguna cantidad de alcohol durante la gestación y al consumo excesivo episódico durante ese período. AbstractDrinking alcohol during pregnancy can lead to different problems with different levels of severity, encompassed by the term Fetal Alcohol Spectrum Disorders. Considering that a safe dose of alcohol during pregnancy has not been determined, the official recommendation of various national and international organizations is abstinence. However, the evidence indicates that although many women are aware that alcohol can alter fetal development, most of them believe that some consumption during pregnancy is acceptable. Through this study, we intend to contribute to the understanding of the relationship between knowledge, attitudes and drinking during pregnancy. To achieve this, we analyze semi structured interviews carried on with puerperal women in Argentina (n = 641). 70.4% of women reported having received some information about a potential adverse effect of alcohol consumption during pregnancy, but few of them had accurate information and only 6.1% mentioned a health professional as source. Information and attitudes were strongly linked. Attitudes were significantly associated to some alcohol consumption during pregnancy and to binge drinking during that period.

scholarly journals Women’s receptivity to Fetal Alcohol Spectrum Disorders prevention approaches: A case study of two regions in Russia

2014 ◽  
Vol 3 (1) ◽  
pp. 5-15 ◽  
Author(s):  
Tatiana Balachova ◽  
Barbara Bonner ◽  
David Bard ◽  
Mark Chaffin ◽  
Galina Isurina ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Fetal Alcohol Spectrum Disorders ◽  
Structured Interview ◽  
Research Data ◽  
Demographic Characteristics ◽  
Sources Of Information ◽  
Fetal Alcohol ◽  
Spectrum Disorders ◽  
Fetal Alcohol Spectrum

Balachova, T., Bonner, B., Bard, D., Chaffin, M., Isurina, G., Owora, A., Tsvetkova, L., & Volkova, E. (2014). Women’s receptivity to Fetal Alcohol Spectrum Disorders prevention approaches: A case study of two regions in Russia. The International Journal Of Alcohol And Drug Research, 3(1), 5-15. doi:10.7895/ijadr.v3i1.158Aims: This study obtained data to inform the development of programs for prevention of Fetal Alcohol Spectrum Disorders (FASD) by examining Russian women’s perceptions about the determinants of their decisions regarding alcohol consumption during pregnancy; the importance of educating professionals and community about FASD; and the credibility of various sources of information.Design: Cross-sectional survey.Setting: Seven women’s clinics in St. Petersburg and the Nizhny Novgorod region in Russia.Participants: Six hundred and forty-eight pregnant and non-pregnant women of childbearing age.Measures: A face-to-face structured interview assessed demographic characteristics, pregnancy status, alcohol consumption, and level of trust in and receptivity to FASD prevention messages.Findings: The most influential contributor to women’s decisions regarding alcohol consumption during pregnancy was their own knowledge, followed by information from an obstetrician/gynecologist or nurse. It was most important to women that obstetrics and gynecology professionals and husbands or partners were knowledgeable about the effects of drinking during pregnancy. Physicians’ recommendations and research data were regarded by the women as the most credible sources of information. There were significant variations in responses by socio-demographic characteristics and alcohol consumption levels. Younger women were more likely to report the contributions of husbands, mothers, and friends or coworkers to their decisions about alcohol consumption and indicated the importance of educating these people. Women at risk for alcohol use during pregnancy reported greater influence of husbands or partners and warning labels on containers on their alcohol consumption.Conclusions: This study emphasizes the importance of broadly disseminating information about FASD, particularly research data, through education of health professionals and the general public in Russia. Women’s socio-demographic characteristics and alcohol consumption levels should be considered in designing prevention programs.

scholarly journals Breastfeeding and maternal alcohol use: Prevalence and effects on child outcomes and fetal alcohol spectrum disorders

2016 ◽  
Vol 63 ◽  
pp. 13-21 ◽  
Author(s):  
Philip A. May ◽  
Julie M. Hasken ◽  
Jason Blankenship ◽  
Anna-Susan Marais ◽  
Belinda Joubert ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Fetal Alcohol Spectrum Disorders ◽  
Child Outcomes ◽  
Fetal Alcohol ◽  
Maternal Alcohol ◽  
Spectrum Disorders ◽  
Fetal Alcohol Spectrum

scholarly journals Alcohol Consumption and Smoking During Pregnancy Alters Maternal Plasma Fatty Acid Composition: Association with Fetal Alcohol Spectrum Disorders (P11-028-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Krista Sowell ◽  
Roberta Holt ◽  
Janet Uriu-Adams ◽  
Christina Chambers ◽  
Claire Coles ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Alcohol Consumption ◽  
Fetal Alcohol Spectrum Disorders ◽  
Docosapentaenoic Acid ◽  
Maternal Plasma ◽  
Fetal Alcohol ◽  
Heavy Alcohol ◽  
Spectrum Disorders ◽  
Fetal Alcohol Spectrum

Abstract Objectives Polyunsaturated fatty acids (PUFA) are vital for optimal fetal neuronal development. This study examined the relationship between maternal alcohol consumption and smoking with plasma fatty acids measured in the third trimester and their association with Fetal Alcohol Spectrum Disorders (FASD). Methods In the parent study, moderate to heavy alcohol-using and low/unexposed comparison women were recruited during mid-pregnancy from two prenatal clinics in Ukraine. The participants’ live-born infants underwent physical and neurobehavioral exams prior to one-year of age. Infants were classified as having FASD if their mothers reported moderate to heavy alcohol consumption and the infant had at least one standardized score below 85 on the Bayley Scales of Infant Development II (BISD-II) with or without physical features of FASD. From the overall cohort, a subset of mother-child pairs was selected representing three groups of cases and controls: Alcohol-Exposed with FASD (n = 30), Alcohol-Exposed Normally Developing (n = 33), or low/unexposed Controls (n = 46). Third trimester maternal plasma samples were analyzed for fatty acids and levels were compared across groups. Results Plasma compositions of omega-6 fatty acids were altered in mothers with FASD infants compared to other groups. More specifically, the % of stearic acid (C18:0), arachidonic acid (AA, C20:4n6) and docosapentaenoic acid (DPAn6, C22:5n6) were significantly higher in mothers with FASD infants than low/unexposed controls or alcohol-exposed mothers with typically developing infants. Alcohol-exposed women who smoked had lower n3-docosapentaenoic acid (DPAn3, C22:5n3) and docosahexaenoic acid (DHA, C22:6n3) and higher DPAn6 than women consuming alcohol alone or abstainers. Conclusions Alterations in fatty acid profiles were observed in moderate to heavy alcohol-consuming mothers with infants classified with FASD compared to alcohol-exposed typically developing infants or controls. These results support the idea that maternal fatty acid status can play a role in the etiology of FASD. Funding Sources This research was funded by support from NIH Research Grant and conducted in conjunction with the Collaborative Initiative on Fetal Alcohol Spectrum Disorders(CIFASD).

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