scholarly journals LASI-DAD study: a protocol for a prospective cohort study of late-life cognition and dementia in India

BMJ Open ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. e030300 ◽  
Author(s):  
Jinkook Lee ◽  
Joyita Banerjee ◽  
Pranali Yogiraj Khobragade ◽  
Marco Angrisani ◽  
A B Dey
Keyword(s):  
Low Income ◽  
Venous Blood ◽  
Late Life ◽  
Epidemiological Data ◽  
Blood Collection ◽  
Computer Assisted ◽  
Clinical Dementia Rating ◽  
Middle Income ◽  
Aging Study ◽  
Longitudinal Aging Study

IntroductionAlzheimer’s disease and related dementias can be considered the epidemic of the 21st century. Particularly, the predicted growth in the size of elderly populations in low-income and middle-income countries is expected to produce a dramatic surge in dementia prevalence and incidence. Although a rising burden of dementia presents an urgent challenge for India, previous efforts to study dementia in the country have relied on non-representative samples in geographically restricted regions. The Harmonised Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD) will provide rich, population-representative data on late-life cognition and dementia and their risk factors for the first time in India.MethodsThe LASI-DAD will recruit a sample of 3000 people aged 60+ years. Their family members or friends, whom respondents nominate as informants, participate in the computer-assisted personal interview. The study sample is drawn from the ongoing, nationally representative Longitudinal Aging Study in India, a multipurpose panel survey of aging. We aim to collect rich data on cognitive and neuropsychological tests, informant reports, and epidemiological data through a comprehensive geriatric assessment, and venous blood collection and assays. For a subsample, we collect neuroimaging data. Data collection is currently in progress in 14 States and Union Territories of India. Clinicians will provide clinical consensus diagnosis based on the Clinical Dementia Rating.Ethics and disseminationEthics approval was obtained from the Indian Council of Medical Research and all collaborating institutions. Anonymised data will be available for the larger research community through a secured website hosted by the Gateway to Global Aging Data platform. Research findings from the LASI-DAD team will be disseminated through journal publications and presentations at professional conferences.

scholarly journals Design and Methodology of the Longitudinal Aging Study in India—Diagnostic Assessment of Dementia

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 660-660
Author(s):  
Jinkook Lee ◽  
Pranali Khobragade ◽  
Joyita Banerjee ◽  
Sandy Chien
Keyword(s):  
Risk Factors ◽  
Sex Education ◽  
Venous Blood ◽  
International Comparisons ◽  
Late Life ◽  
Cognitive Tests ◽  
Aging Study ◽  
Longitudinal Aging Study ◽  
Nationally Representative ◽  
Rich Data

Abstract Longitudinal Aging Study in India is a nationally representative survey of the health, economic, and social wellbeing of the Indian population aged 45 and older. LASI-DAD is an in-depth study of late-life cognition and dementia, drawing a sub-sample of over 4,000 LASI respondents aged 60 or older. Respondents underwent a battery of cognitive tests, while their informants were interviewed about their cognitive and health conditions. A common set of cognitive tests was selected to enable international comparisons, and additional cognitive tests suitable for illiterate and innumerate populations were also selected. Rich data on risk factors of dementia were collected through health examinations, venous blood assays, and genotyping. The response rate was 82.9%, varying across sex, education, and urbanicity. LASI-DAD provides an opportunity to study late-life cognition and dementia and their risk factors in the older population in India and to gain further insights through cross-country analysis.

Safe Reopening Following Generalized Lockdowns: A Strategy Based on Evidence from 24 Worldwide Countries

2021 ◽  
Author(s):  
Abu S. Shonchoy ◽  
Khandker S. Ishtiaq ◽  
Sajedul Talukder ◽  
Nasar U. Ahmed ◽  
Rajiv Chowdhury
Keyword(s):  
Low Income ◽  
Large Scale ◽  
Simulation Analysis ◽  
Epidemiological Data ◽  
World Health ◽  
Optimal Timing ◽  
Middle Income ◽  
Capacity Limits ◽  
Positive Rate ◽  
Health Organization

Abstract While the effectiveness of lockdowns to reduce Coronavirus Disease-2019 (COVID-19) transmission is well established, uncertainties remain on the lifting principles of these restrictive interventions. World Health Organization recommends case positive rate of 5% or lower as a threshold for safe reopening. However, inadequate testing capacity limits the applicability of this recommendation, especially in the low-income and middle-income countries (LMICs). To develop a practical reopening strategy for LMICs, in this study, we first identify the optimal timing of safe reopening by exploring accessible epidemiological data of 24 countries during the initial COVID-19 surge. We find that safely reopening requires a two-week waiting period, after the crossover of daily infection and recovery rates – coupled with a post-crossover continuous negative trend in daily new cases. Epidemiologic SIRM model-based simulation analysis validates our findings. Finally, we develop an easily interpretable large-scale reopening (LSR) index, which is an evidence-based toolkit – to guide/inform the reopening decisions for LMICs.

Emergence and persistence of late life depression: a 3-year follow-up of the Longitudinal Aging Study Amsterdam

2001 ◽  
Vol 65 (2) ◽  
pp. 131-138 ◽  
Author(s):  
A.T.F Beekman ◽  
D.J.H Deeg ◽  
S.W Geerlings ◽  
R.A Schoevers ◽  
J.H Smit ◽  
...  
Keyword(s):  
Late Life ◽  
Late Life Depression ◽  
Longitudinal Aging Study Amsterdam ◽  
Aging Study ◽  
Longitudinal Aging Study

scholarly journals Late-life depression symptom dimensions and cognitive functioning in the Longitudinal Aging Study Amsterdam (LASA)

2016 ◽  
Vol 201 ◽  
pp. 171-178 ◽  
Author(s):  
Anamaria Brailean ◽  
Hannie C. Comijs ◽  
Marja J. Aartsen ◽  
Martin Prince ◽  
A. Matthew Prina ◽  
...  
Keyword(s):  
Cognitive Functioning ◽  
Late Life ◽  
Depression Symptom ◽  
Late Life Depression ◽  
Symptom Dimensions ◽  
Longitudinal Aging Study Amsterdam ◽  
Aging Study ◽  
Longitudinal Aging Study

scholarly journals Clinico demographic profile of patients with bronchiectasis – A cross sectional study

2021 ◽  
Vol 6 (2) ◽  
pp. 111-116
Author(s):  
BG Saroja
Keyword(s):  
Low Income ◽  
Epidemiological Data ◽  
Cross Sectional Study ◽  
Study Data ◽  
Adult Patients ◽  
Common Symptom ◽  
Cross Sectional ◽  
Middle Income ◽  
Sputum Production ◽  
Few Data

Bronchiectasis (BE) is a common but neglected chronic lung disease. Most epidemiological data are limited to cohorts from Europe and the USA, with few data from low income and middle income countries “Bronchiectasis” is a chronic debilitating respiratory condition, natural history of Bronchiectasis is variable, some patients have only a few chest infections per year with no disease progression overtime, while others have more frequent prolonged infective episodes and progress more quickly to respiratory failure with an associated increase in risk of death.A vicious cycle of infection and inflammation exists in damaged airways with patient suffering from persistent cough, purulent sputum production, recurrent chest infections and general malaise, associated with increased morbidity and reduced quality of life and socioeconomic, cost of long term management is significant. 162 CT confirmed adult patients≥ 18 years were included in the study, data of patients were retrieved demography, clinical features, causative factors, spirometry and imaging reports were studied and analysed. 162 adult patients were included in the study. Males (54%) and more than 50 years age group population [64%] was predominantly affected. 58% were non-smokers.Chronic cough (100%) with sputum production (86%) and fatigue (78%) were the most common symptoms, digital clubbing and crackles were the most common examination findings. Dominant cause of BE was post infection (46%) followed by COPD (20%), ABPA (10%) and miscellaneous causes. Obstructive abnormality (42%) was the most common spirometric pattern observed. Higher incidence of cystic BE (57%) was found in our study. Patients > 50 years and males were predominantly affected. Most of the study population had never smoked. Most common symptom found was chronic productive cough and fatigue. Etiology of BE is heterogeneous. Post Tuberculosis BE variety was common. BE in COPD patients was not less common. Central Bronchiectasis was not uncommon.

scholarly journals A novel index-based decision support toolkit for safe reopening following a generalized lockdown in low and middle-income countries

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Abu S. Shonchoy ◽  
Khandker S. Ishtiaq ◽  
Sajedul Talukder ◽  
Nasar U. Ahmed ◽  
Rajiv Chowdhury
Keyword(s):  
Low Income ◽  
Large Scale ◽  
Epidemiological Data ◽  
World Health ◽  
Optimal Timing ◽  
Middle Income ◽  
Capacity Limits ◽  
Middle Income Countries ◽  
Positive Rate ◽  
Health Organization

AbstractWhile the effectiveness of lockdowns to reduce Coronavirus Disease-2019 (COVID-19) transmission is well established, uncertainties remain on the lifting principles of these restrictive interventions. World Health Organization recommends case positive rate of 5% or lower as a threshold for safe reopening. However, inadequate testing capacity limits the applicability of this recommendation, especially in the low-income and middle-income countries (LMICs). To develop a practical reopening strategy for LMICs, in this study, we first identify the optimal timing of safe reopening by exploring accessible epidemiological data of 24 countries during the initial COVID-19 surge. We find that a safe opening can occur two weeks after the crossover of daily infection and recovery rates while maintaining a negative trend in daily new cases. Epidemiologic SIRM model-based example simulation supports our findings. Finally, we develop an easily interpretable large-scale reopening (LSR) index, which is an evidence-based toolkit—to guide/inform reopening decision for LMICs.

FC28-06 - ADHD in elderly. First data from a dutch epidemiological cohort (LASA study)

2011 ◽  
Vol 26 (S2) ◽  
pp. 1976-1976
Author(s):  
J.J.S. Kooij ◽  
Keyword(s):  
Age Groups ◽  
Epidemiological Data ◽  
Diagnostic Interview ◽  
Longitudinal Aging Study Amsterdam ◽  
Aging Study ◽  
General Dutch Population ◽  
Somatic Disorders ◽  
Longitudinal Aging Study ◽  
Treatment Facilities ◽  
The Impact

IntroductionADHD occurs in 3–5% of children and adults. Yet little is known about ADHD in elderly.ObjectivesTo review the literature and to present first Dutch epidemiological data on ADHD in elderly (VUmc/LASA and PsyQ).AimsThe study aims to estimate the prevalence of ADHD in eldery and to correlate symptoms of ADHD with comorbidity patterns, cognitive decline and somatic disorders. This knowledge may help predict the future of the current group of adults with ADHD.MethodsThe Longitudinal Aging Study Amsterdam (LASA) included a selfreport questionnaire for ADHD in 2009 in around 1500 elderly, aged 63–94 years. From those with low, intermediate and high scores, a random sample was interviewed using the DIVA, a structured Diagnostic Interview for ADHD in adults (N = 234).ResultsFirst data on prevalence of ADHD in elderly in the general Dutch population will be discussed. The long term consequences of the persistence of the disorder in adults and elderly, and the impact for the organisation of treatment of this lifespan disorder will be reviewed.ConclusionsThe continuity of ADHD symptoms and impairment from childhood into to old age, may pose psychiatric services for important questions like the usefulness of separate treatment facilities for different age groups in case of a lifespan disorder like ADHD.

scholarly journals Late-Life Cognition and Dementia in India: New Insights From LASI-DAD

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 659-659
Author(s):  
Jinkook Lee
Keyword(s):  
Older Adults ◽  
Cognitive Aging ◽  
Neuropsychological Test ◽  
Late Life ◽  
Cognitive Domains ◽  
Assessment Protocol ◽  
Aging Study ◽  
Dementia Research ◽  
Depth Study ◽  
Longitudinal Aging Study

Abstract With more than1.35 billion people, India, the second-most populous country in the world, is soon to experience rapid aging of its population. By2050, India’s older population is projected to reach320 million (about the current size of the entire U.S. population). In this session we introduce the Longitudinal Aging Study in India – Diagnostic Assessment of Dementia (LASI-DAD), a new cohort study designed to advance dementia research to better understand late-life cognition, cognitive aging, cognitive impairment, and dementia, as well as their risk and protective factors. LASI is a prospective, multi-purpose population survey of older adults aged45 and older, representative of the entire country and of each state (N~72,000). LASI-DAD is an in-depth study of late-life cognition and dementia, drawing a sub-sample of older adults aged60 and older from LASI (N~4,300). It administered the Harmonized Cognitive Assessment Protocol (HCAP), which consists of a pair of in-person interviews, one with the target respondent and one with an informant nominated by the respondent. The respondent interview includes a neuropsychological test battery designed to measure a range of key cognitive domains affected by cognitive aging and Alzheimer’s Diseases. We organize the session to showcase LASI-DAD. Specifically, the session consists of four papers, including: (1) the introduction of the design and methodology, (2) the latent structure of neuropsychological test results, (3) the investigation of the relationship between visual impairment and cognition, and (4) the examination of female disadvantage in dementia and its association with cross-state variations in gender inequality.

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