scholarly journals Association between quantitative sensory testing and pain or disability in paediatric chronic pain: protocol for a systematic review and meta-analysis

BMJ Open ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. e031861 ◽  
Author(s):  
Daniel Eric Schoth ◽  
Markus Blankenburg ◽  
Julia Wager ◽  
Philippa Broadbent ◽  
Jin Zhang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Chronic Pain ◽  
Quantitative Sensory Testing ◽  
Ethical Issues ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Anatomical Site ◽  
Thermal Stimulus ◽  
Sensory Testing ◽  
Pain Mechanisms

IntroductionThis protocol describes the objective and methods of a systematic review of the association between quantitative sensory testing (QST) measures and pain intensity or disability in paediatric chronic pain (PCP). The review will also assess whether the relationship strength is moderated by variables related to the QST method and pain condition; the use of QST in PCP (modalities, outcome measures and anatomical test sites as well as differentiating between pain mechanisms (eg, neuropathic vs nociceptive) and in selecting analgesics); the reliability of QST across the paediatric age range; the ability of QST to differentiate patients with chronic pain from healthy controls; and differences between anatomical test sites.Methods and analysisMedline, PsycINFO, CINHAL, Web of Science, Scopus, Cochrane Library and OpenGrey will be searched. English language studies will be eligible if they recruit a sample aged 6–24 (inclusive) with chronic pain, including primary and secondary pain; apply at least one of the following QST modalities: chemical, electrical, mechanical (subgroups include pressure, punctate/brush and vibratory) or thermal stimulus to measure perception of noxious or innocuous stimuli applied to skin, muscle or joint; use a testing protocol to control for stimulus properties: modality, anatomical site, intensity, duration and sequence. Following title and abstract screening, the full texts of relevant records will be independently assessed by two reviewers. For eligible studies, one reviewer will extract study characteristics and data, and another will check for accuracy. Both will undertake independent quality assessments using the Appraisal Tool for Cross-Sectional Studies. A qualitative synthesis will be presented with discussion centred around different QST modalities. Where eligible data permit, meta-analyses will be performed separately for different QST modalities using comprehensive meta-analysis.Ethics and disseminationReview findings will be reported in a peer-reviewed journal and presented at conferences. The study raises no ethical issues.PROSPERO registration numberCRD42019134069.

scholarly journals Noninvasive motor cortex stimulation effects on quantitative sensory testing in healthy and chronic pain subjects: a systematic review and meta-analysis

Pain ◽  
2020 ◽  
Vol 161 (9) ◽  
pp. 1955-1975 ◽  
Author(s):  
Stefano Giannoni-Luza ◽  
Kevin Pacheco-Barrios ◽  
Alejandra Cardenas-Rojas ◽  
Piero F. Mejia-Pando ◽  
Maria A. Luna-Cuadros ◽  
...  
Keyword(s):  
Systematic Review ◽  
Chronic Pain ◽  
Motor Cortex ◽  
Quantitative Sensory Testing ◽  
Meta Analysis ◽  
Motor Cortex Stimulation ◽  
Sensory Testing

scholarly journals Quantitative sensory testing in painful osteoarthritis: a systematic review and meta-analysis

2012 ◽  
Vol 20 (10) ◽  
pp. 1075-1085 ◽  
Author(s):  
A.K. Suokas ◽  
D.A. Walsh ◽  
D.F. McWilliams ◽  
L. Condon ◽  
B. Moreton ◽  
...  
Keyword(s):  
Systematic Review ◽  
Quantitative Sensory Testing ◽  
Meta Analysis ◽  
Sensory Testing

scholarly journals Quantitative sensory testing in feline osteoarthritic pain – a systematic review and meta-analysis

2020 ◽  
Vol 28 (7) ◽  
pp. 885-896
Author(s):  
B.P. Monteiro ◽  
C. Otis ◽  
J.R.E. del Castillo ◽  
R. Nitulescu ◽  
K. Brown ◽  
...  
Keyword(s):  
Systematic Review ◽  
Quantitative Sensory Testing ◽  
Meta Analysis ◽  
Sensory Testing ◽  
Osteoarthritic Pain

scholarly journals Efficacy and Safety of Ultrasound-Guided Radiofrequency Treatment for Chronic Pain in Patients with Knee Osteoarthritis: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Yuzhao Huang ◽  
Qiufang Deng ◽  
Liuqing Yang ◽  
Jiahui Ma ◽  
Ziyang Wang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Chronic Pain ◽  
Pain Relief ◽  
Knee Osteoarthritis ◽  
Meta Analysis ◽  
Knee Function ◽  
Cochrane Library ◽  
Efficacy And Safety ◽  
Ultrasound Guided

Background. Knee osteoarthritis (KOA) is a common degenerative disease associated with joint dysfunction and pain. Ultrasound-guided radiofrequency (RF) may be a promising therapy in the treatment of chronic pain for KOA patients. Objective. To evaluate the efficacy and safety of ultrasound-guided RF treatment for chronic pain in patients with KOA. Design. A systematic review was conducted, and a meta-analysis was carried out when possible. Setting. We examined the studies evaluating the clinical efficiency of ultrasound-guided RF on chronic pain in KOA population. Method. A systematic review for the efficacy and safety of ultrasound-guided RF treatment for pain management of KOA patients was carried out in PubMed, EMBASE, Cochrane Library, Web of Science, Wanfang Data, and China National Knowledge Infrastructure (CNKI) from the date of inception to February 2020, and a meta-analysis was conducted. The primary outcomes of pain intensity (visual analogue scale or numerical rating scale) and knee function [the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)] were evaluated from baseline to various follow-up times by random-effects model. Heterogeneity was assessed by I2 statistic and the potential sources of heterogeneity by subgroup and metaregression analyses, respectively. Results. Eight publications with 256 patients were included in the meta-analysis. RF could relieve pain with −4.196 of pooled mean difference and improve knee function by decreasing 23.155 points in WOMAC. Three patients had ecchymosis, two with hypoesthesia and one with numbness after the procedure, and improved within 6 months. Furthermore, study design and treatment target were the sources of heterogeneity by subgroup and metaregression analyses, accounting for 37% and 74% of variances, respectively. Target of genicular nerve achieved better pain relief than intra-articular or sciatic nerve. Sensitivity analysis showed that removal of any single study was unlikely to overturn the findings. Limitations. There were some limitations in the study. Firstly, the small number of relevant studies limited the confidence level of the meta-analysis. Also, the significant heterogeneity may not be explained due to the limited data. Secondly, the direct comparison of two different guidance methods (ultrasound vs. fluoroscopy) for RF therapy is lacking. In addition, the outcomes were blindly assessed in the meta-analysis from all studies according to evaluation of bias, which could affect the reality of the data. Finally, most of the studies only provided short follow-up times, so we could not analyze the long-term effectiveness of ultrasound-guided RF in the treatment of patients with KOA. Conclusions. Ultrasonography is an effective, safe, nonradiative, and easily applicable guidance method for RF in pain relief and functional improvement in KOA patients.

scholarly journals Incidence of HIV and HCV in people who inject drugs: a systematic and meta-analysis review protocol

BMJ Open ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. e041482
Author(s):  
Asaad Sharhani ◽  
Zahra Jorjoran Shushtari ◽  
Azam Rahmani ◽  
Bahram Armoon ◽  
Mehdi Noroozi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Mathematical Modelling ◽  
Mathematical Models ◽  
People Who Inject Drugs ◽  
Ethical Issues ◽  
Meta Analysis ◽  
Research Question ◽  
Cochrane Library ◽  
Case Definitions ◽  
Cross Sectional

IntroductionHIV and hepatitis C virus (HCV) are major health concerns globally. This systematic review and meta-analysis protocol study aims to estimate the incidence of HIV and HCV among people who inject drugs (PWIDs) by reviewing studies that have applied mathematical modelling. The primary purpose of this systematic review is to identify and review mathematical modelling studies of HIV and HCV incidence in PWIDs.Methods and analysis cohort, cross-sectional and clinical trial studies conducted to estimate the incidence of HIV and HCV based on mathematical models or have evaluated the effectiveness of mathematical models will be considered for inclusion in the review. A comprehensive search applying a Cochrane approach will be used to identify relevant primary studies, published between January 2000 and July 2020, and indexed in PubMed, EMBASE, Opengrey, WOS, SCOPUS and Cochrane Library with no restriction on language. This protocol was prepared according to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). Study selection and data extraction will be performed by two independent reviewers. Assessment of risk of bias will be implemented using forms of the Critical Appraisal Skills Programme. Publication bias will be assessed by funnel plots, Begg’s and Egger’s tests. A meta-analysis will be conducted to answer the first research question, ‘What is the incidence of HIV and HCV when applying mathematical model in PWID?’. Clinical heterogeneity will be assessed by looking at the characteristics of participants, method of diagnosis and case definitions in the included primary studies. In addition, subgroup analyses will be conducted for population and secondary outcomes.Ethics and disseminationThere are no ethical issues related to this study. The findings will be published in peer-reviewed scientific journals and presented at international and national conferences.PROSPERO registration numberCRD42019126476.

scholarly journals Psychometric properties of quantitative sensory testing focusing on healthy and patients with shoulder pain: a systematic review protocol

2021 ◽  
Vol 8 (3) ◽  
pp. 253
Author(s):  
Paraskevi Bilika ◽  
Konstantina Savvoulidou ◽  
Achilleas Paliouras ◽  
Zacharias Dimitriadis ◽  
Evdokia Billis ◽  
...  
Keyword(s):  
Systematic Review ◽  
Psychometric Properties ◽  
Shoulder Pain ◽  
Quantitative Sensory Testing ◽  
Somatosensory System ◽  
Cochrane Library ◽  
Sensory Testing ◽  
Measurement Instruments ◽  
Health Measurement ◽  
Level Of Evidence

<p class="abstract"><strong>Background:</strong> Quantitative sensory testing (QST) is a battery of non-invasive psychophysical methods to assess the function of somatosensory system. Although the use of QST is widespread and several studies in patients with chronic shoulder pain have used it, the level of evidence for the psychometric properties has not been established. The aim of this protocol is to investigate, through a systematic review, the level of evidence for the psychometric properties of QST in the shoulder.</p><p class="abstract"><strong>Methods:</strong> For conducting and reporting this review the preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines and the consensus-based standards for the selection of health measurement instruments (COSMIN) guidelines will be used. Nine databases including PubMed, Medline, AMED (via EBSCO), PEDRO, Embase, Web of Science, Scopus, SportDiscus, Google Scholar and Cochrane Library will be searched for the period from their inception until September 2021. Two reviewers (BP and SK) will independently evaluate the retrieved articles (titles and abstracts) and the psychometric characteristics checklist based on the standards from the COSMIN. The modified grading of recommendations assessment, development, and evaluation (GRADE) approach will be used to assess the overall quality of the evidence.</p><p class="abstract"><strong>Conclusions: </strong>Evaluation of the level of evidence for the psychometric properties of QST in the shoulder is an essential step for evidence-based assessment in clinical practice.</p><p class="abstract"><strong>Trial registration:</strong> PROSPERO registration number is CRD42021232778.</p>

scholarly journals Predictors of chronic pain and level of physical function in total knee arthroplasty: a protocol for a systematic review and meta-analysis

BMJ Open ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. e037674
Author(s):  
Unni Olsen ◽  
Maren Falch Lindberg ◽  
Eva Marie-Louise Denison ◽  
Christopher James Rose ◽  
Caryl Lynn Gay ◽  
...  
Keyword(s):  
Systematic Review ◽  
Chronic Pain ◽  
Total Knee Arthroplasty ◽  
Physical Function ◽  
Knee Arthroplasty ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Impaired Function ◽  
Total Knee ◽  
Prospective Longitudinal

IntroductionOne in five patients undergoing total knee arthroplasty (TKA) experience unchanged or worse pain and physical function 1 year after surgery. Identifying risk factors for unfavourable outcomes is necessary to develop tailored interventions to minimise risk. There is a need to review more current literature with updated methodology that addresses the limitations of earlier systematic reviews and meta-analyses. We present a Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols compliant protocol for a systematic review and meta-analysis of predictors of chronic pain and impaired function after TKA.Methods and analysisThis review will include prospective longitudinal observational studies, or randomised trials (including cluster and crossover designs) that report arm-wise predictors of chronic postsurgical pain or impaired physical function at 3 months, 6 months or 12 months. A comprehensive literature search of studies published between 2000 and 2019 will be performed in Medline, Embase, CINAHL, Cochrane Library and PEDro. Blinded assessment with consensus agreement will be applied for inclusion of studies, data extraction and assessment of bias risk (Quality in Prognosis Studies tool). The co-primary outcomes, pain and impaired function, at 12 months after TKA will be analysed separately. Estimates of association between each outcome and any preoperative or intraoperative factor that may predict chronic pain or impaired physical function will be extracted from the included studies, where possible. For randomised studies, results will only be extracted from TKA arms (or the first period of crossover trials). Estimates of association from the primary evidence will be synthesised narratively, and quantitatively using multivariate meta-analysis to provide ‘pooled’ estimates of association. Subgroup and sensitivity analyses will be performed. Certainty of evidence for each predictor will be derived from the Grading of Recommendations Assessment, Development and Evaluation framework.Ethics and disseminationNo ethical issues are associated with this project. The results from this review will be published in peer-reviewed journals and presented at international conferences.PROSPERO registration numberCRD42018079069.

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