scholarly journals Association between dietary antioxidant vitamins intake and homocysteine levels in middle-aged and older adults with hypertension: a cross-sectional study

BMJ Open ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. e045732
Author(s):  
Xiaolin Peng ◽  
Qin Gao ◽  
Juan Zhou ◽  
Jianping Ma ◽  
Dan Zhao ◽  
...  
Keyword(s):  
Older Adults ◽  
Cross Sectional Study ◽  
Antioxidant Vitamins ◽  
Inverse Association ◽  
Dietary Intakes ◽  
Sectional Study ◽  
Middle Aged ◽  
Cross Sectional ◽  
Logistic Regression Models ◽  
Dietary Antioxidant

ObjectivesPlasma total homocysteine (tHcy) has been implicated in the development of cardiovascular disease. This study aimed to assess the relationship of dietary antioxidant vitamins intake with tHcy levels in middle-aged and older adults with hypertension.DesignA cross-sectional study.SettingThe survey was conducted in the Nanshan district of Shenzhen.ParticipantsA total of 1465 middle-aged and older adults with hypertension were included between July and September of 2013.MeasurementsHyperhomocysteinaemia (HHcy) was defined as tHcy ≥15 µmol/L. Some dietary antioxidant vitamins (vitamin C (VC) and vitamin E (VE), carotenes, retinol, lutein) intake was estimated using the Food Frequency Questionnaire. Sociodemographic and potential covariates were evaluated through questionnaires, anthropometric measurements and blood tests. The association between dietary intakes of antioxidant vitamins and tHcy concentration were evaluated by multiple linear regression analyses after napierian logarithm transformed. Multiple logistic regression models were further used to determine ORs and 95% CIs.ResultsThe β (95% CIs) of VC intake and tHcy was −0.050 (−0.084 to –0.016). Compared with the lowest quartile in the fully adjusted model, the ORs (95% CIs) for HHcy levels across quartiles of dietary VC intake were 0.82 (0.57 to 1.16), 0.49 (0.33 to 0.74) and 0.40 (0.22 to 0.74) (p for trend=0.001). The β (95% CIs) of retinol intake and tHcy was −0.021 (−0.041 to –0.002) and the ORs (95% CIs) in the third quartile of retinol intake was 0.61 (0.42 to 0.86), while the effect for the highest quartile was not significant (p for trend=0.951). No significant association was observed between dietary VE, carotenes and lutein intake and HHcy.ConclusionsA linear inverse association between dietary VC intake and HHcy prevalence, and an L-shaped association between dietary retinol intake and HHcy prevalence were found in Chinese middle-aged and older adults with hypertension.

scholarly journals Association of Triglyceride Glucose (TyG) Index With Leukoaraiosis in Middle-aged and Older Adults: A Cross-sectional Study

2020 ◽  
Author(s):  
Dong-Hyuk Jung ◽  
Byoung Jin Park ◽  
Yong-Jae Lee
Keyword(s):  
Older Adults ◽  
Brain Mri ◽  
Multiple Logistic Regression Analysis ◽  
Fasting Blood Glucose ◽  
Cross Sectional Study ◽  
Health Examination ◽  
Sectional Study ◽  
Middle Aged ◽  
Cross Sectional ◽  
Tyg Index

Abstract Background: Leukoaraiosis refers to lesions of high signal intensity in the periventricular and subcortical white matter that result from chronic microvascular ischemic damage to the brain. Increasing evidence suggests that the triglyceride glucose (TyG) index is associated with arterial stiffness and cardiovascular disease, which are both closely related to ischemic arterial damage. We hypothesized that the serum TyG index could be associated with cerebrovascular microangiopathy as measured by leukoaraiosis among middle-aged and older adults.Methods: This cross-sectional study included 2,162 Korean adults aged ≥45 years who participated in a health examination program between 2010 and 2011. TyG index was calculated as Ln (fasting triglycerides (mg/dl) × fasting blood glucose (mg/dl)/2). TyG index quartiles were categorized as follows: Q1, ≤8.12; Q2, 8.13-8.50 Q2, 8.51-8.89; and Q4, ≥8.90. The odds ratios (ORs) and 95% confidence intervals (95% CIs) for leukoaraiosis based on brain MRI scans were calculated across TyG index quartiles using multiple logistic regression analysis.Results: The overall prevalence of leukoaraiosis was 5.4% and increased with serum TyG index quartiles. Compared to the lowest quartile, the ORs (95% CIs) of the highest TyG index quartile for leukoaraiosis was 2.37 (1.17-4.79) after adjusting for age, sex, body mass index, smoking status, alcohol intake, regular exercise, mean arterial pressure, total cholesterol, HDL cholesterol levels, hypertension, and type 2 diabetes.Conclusions: The serum TyG index was positively and independently associated with leukoaraiosis. Our findings indicate that the TyG index might be a useful additional measure for assessing cerebrovascular microangiopathy in clinical settings.

scholarly journals Anthropometric indicators as a discriminator of sarcopenia in community-dwelling older adults of the Amazon region: a cross-sectional study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Cássio Lima Esteves ◽  
Daniela Gonçalves Ohara ◽  
Areolino Pena Matos ◽  
Vânia T. K. Ferreira ◽  
Natalia C. R. Iosimuta ◽  
...  
Keyword(s):  
Older Adults ◽  
Roc Curve ◽  
Cross Sectional Study ◽  
Community Dwelling ◽  
Screening Tools ◽  
Inverse Association ◽  
Sectional Study ◽  
Cross Sectional ◽  
Anthropometric Indicators ◽  
Community Dwelling Older Adults

Abstract Background Sarcopenia is a geriatric syndrome associated with negative health outcomes and the use of viable alternative screening tools may help in the diagnosis of this condition. This study aimed to analyze the association of sarcopenia with anthropometric indicators among community-dwelling older adults and to identify cut-off points for such indicators as a discriminant criterion for predicting sarcopenia. Methods This was a cross-sectional study conducted on community-dwelling older adults ≥60 years old (n = 411) of both sexes from Macapá, Amapá, Brazil. Socioeconomic, clinical and anthropometric data (arm circumference - AC, waist circumference - WC, calf circumference - CC and body mass index – BMI) were collected using a structured form. Sarcopenia was identified according to the EWGSOP 2 consensus. The association between anthropometric indicators and sarcopenia was performed using logistic regression and cut-off points established from the ROC Curve. Statistical significance was defined as p ≤ 0.05. Results Adjusted analysis indicated an independent and inverse association between sarcopenia and the anthropometric indicators: AC (odds ratio, OR: 0.63; 95% confidence interval, 95%CI: 0.53–0.76), CC (OR: 0.73; 95%CI: 0.62–0.85), WC (OR: 0.93; 95%CI: 0.90–0.97) and BMI (OR: 0.64; 95%CI: 0.53–0.76). The following cut-off points for older men and women represented the discriminant criterion for the presence of sarcopenia: WC (≤97 and ≤ 86 cm), CC (≤33 and ≤ 31 cm), AC (≤27 cm) and BMI (≤24.8 kg/m2 and ≤ 24.5 kg/m2) (area under the ROC curve superior to 0.70). BMI and AC were the indicators with the highest ability to discriminate older adults of both sexes with sarcopenia. Conclusions An increase of one unit of the indicators can reduce the probability of occurrence of sarcopenia. All indicators were considered to discriminate the occurrence of sarcopenia, with emphasis on BMI and AC, and could be used to screen for this condition among community-dwelling older adults.

scholarly journals Dietary patterns, gender, and weight status among middle-aged and older adults in Taiwan: a cross-sectional study

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Miriam Adoyo Muga ◽  
Patrick Opiyo Owili ◽  
Chien-Yeh Hsu ◽  
Hsiao-Hsien Rau ◽  
Jane C-J Chao
Keyword(s):  
Older Adults ◽  
Dietary Patterns ◽  
Weight Status ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Middle Aged ◽  
Cross Sectional
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