scholarly journals Long-term outcomes following severe COVID-19 infection: a propensity matched cohort study

2021 ◽  
Vol 8 (1) ◽  
pp. e001080
Author(s):  
Joanne McPeake ◽  
Martin Shaw ◽  
Pamela MacTavish ◽  
Kevin G Blyth ◽  
Helen Devine ◽  
...  
Keyword(s):  
Critical Care ◽  
Cohort Study ◽  
Optimal Recovery ◽  
Long Term Outcomes ◽  
Significant Difference ◽  
Observational Cohort ◽  
Using Data ◽  
Physical Consequences ◽  
Social Recovery

BackgroundThere are limited data describing the long-term outcomes of severe COVID-19. We aimed to evaluate the long-term psychosocial and physical consequences of severe COVID-19 for patients.MethodsWe conducted a multicentre observational cohort study; between 3 and 7 months posthospital discharge, patients who had been admitted to critical care due to severe COVID-19 were invited to an established recovery service. Standardised questionnaires concerning emotional, physical and social recovery, including information on employment, were completed by patients. Using propensity score matching, we explored outcomes between patients admitted to critical care with and without COVID-19, using data from the same recovery programme.ResultsBetween July 2020 and December 2020, 93 patients who had been admitted to critical with COVID-19 participated. Emotional dysfunction was common: 46.2% of patients had symptoms of anxiety and 34.4% symptoms of depression. At follow-up 53.7% of previously employed patients had returned to employment; there was a significant difference in return to employment across the socio-economic gradient, with lower numbers of patients from the most deprived areas returning to employment (p=0.03). 91 (97.8%) COVID-19 patients were matched with 91 non-COVID-19 patients. There were no significant differences in any measured outcomes between the two cohorts.InterpretationEmotional and social problems are common in survivors of severe COVID-19 infection. Coordinated rehabilitation is required to ensure patients make an optimal recovery.

scholarly journals Long term outcomes following critical care hospital admission: A prospective cohort study of UK biobank participants✰,✰✰,★

2021 ◽  
Vol 6 ◽  
pp. 100121
Author(s):  
Joanne McPeake ◽  
Theodore J Iwashyna ◽  
Philip Henderson ◽  
Alastair H Leyland ◽  
Daniel Mackay ◽  
...  
Keyword(s):  
Critical Care ◽  
Cohort Study ◽  
Hospital Admission ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Care Hospital ◽  
Uk Biobank ◽  
Long Term Outcomes

scholarly journals Multimorbidity and its relationship with long-term outcomes following critical care discharge: a prospective cohort study

CHEST Journal ◽  
2021 ◽  
Author(s):  
Joanne McPeake ◽  
Tara Quasim ◽  
Philip Henderson ◽  
Alastair H. Leyland ◽  
Nazir I. Lone ◽  
...  
Keyword(s):  
Critical Care ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Long Term Outcomes

scholarly journals Postoperative Complications and Long-Term Quality of Life After Multimodality Treatment for Esophageal Cancer: An Analysis of the Prospective Observational Cohort Study of Esophageal-Gastric Cancer Patients (POCOP)

2021 ◽  
Author(s):  
E. Jezerskyte ◽  
◽  
M. I. van Berge Henegouwen ◽  
H. W. M. van Laarhoven ◽  
J. J. van Kleef ◽  
...  
Keyword(s):  
Cohort Study ◽  
Postoperative Complications ◽  
Anastomotic Leakage ◽  
Observational Cohort Study ◽  
Prospective Observational Cohort Study ◽  
Significant Difference ◽  
Observational Cohort ◽  
Gastric Cancer Patients

Abstract Background Esophagectomy has major effects on health-related quality of life (HR-QoL). Postoperative complications might contribute to a decreased HR-QOL. This population-based study aimed to investigate the difference in HR-QoL between patients with and without complications after esophagectomy for cancer. Methods A prospective comparative cohort study was performed with data from the Netherlands Cancer Registry (NCR) and Prospective Observational Cohort Study of Esophageal-Gastric Cancer Patients (POCOP). All patients with esophageal and gastroesophageal junction (GEJ) cancer after esophagectomy in the period 2015–2018 were enrolled. The study investigated HR-QoL at baseline, then 3, 6, 9, 12, 18, and 24 months postoperatively, comparing patients with and without complications as well as with and without anastomotic leakage. Results The 486 enrolled patients comprised 270 patients with complications and 216 patients without complications. Significantly more patients with complications had comorbidities (69.6% vs 57.3%; p = 0.001). No significant difference in HR-QoL was found over time between the patients with and without complications. In both groups, a significant decline in short-term HR-QoL was found in various HR-QoL domains, which were restored to the baseline level during the 12-month follow-up period. No significant difference was found in HR-QoL between the patients with and without anastomotic leakage. The patients with grades 2 and 3 anastomotic leakage reported significantly more “choking when swallowing” at 6 months (ß = 14.5; 95% confidence interval [CI], − 24.833 to − 4.202; p = 0.049), 9 months (ß = 22.4, 95% CI, − 34.259 to − 10.591; p = 0.007), and 24 months (ß = 24.6; 95% CI, − 39.494 to − 9.727; p = 0.007) than the patients with grade 1 or no anastomotic leakage. Conclusion In general, postoperative complications were not associated with decreased short- or long-term HR-QoL for patients after esophagectomy for esophageal or GEJ cancer. The temporary decrease in HR-QoL likely is related to the nature of esophagectomy and reconstruction itself.

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