scholarly journals Age-related changes in the effects of strength training on lower leg muscles in healthy individuals measured using MRI

2017 ◽  
Vol 3 (1) ◽  
pp. e000249 ◽  
Author(s):  
Maria Psatha ◽  
Zhiqing Wu ◽  
Fiona Gammie ◽  
Aivaras Ratkevicius ◽  
Henning Wackerhage ◽  
...  
Keyword(s):  
Strength Training ◽  
Lower Leg ◽  
Healthy Individuals ◽  
Leg Muscles ◽  
Age Related ◽  
Age Related Changes

scholarly journals Assessment of age-related changes of salivary immunoglobulin a levels among healthy individuals

2021 ◽  
Vol 13 (5) ◽  
pp. 461
Author(s):  
DipakBaliram Patil ◽  
ManishkumarDinkar Shete ◽  
Priyatam Karade ◽  
Rutuja Chopade ◽  
Neha Gandhi ◽  
...  
Keyword(s):  
Immunoglobulin A ◽  
Healthy Individuals ◽  
Age Related ◽  
Salivary Immunoglobulin A ◽  
Age Related Changes

scholarly journals Age-Related Differences in Percentages of Regulatory and Effector T Lymphocytes and Their Subsets in Healthy Individuals and Characteristic STAT1/STAT5 Signalling Response in Helper T Lymphocytes

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Marija Holcar ◽  
Aleš Goropevšek ◽  
Alojz Ihan ◽  
Tadej Avčin
Keyword(s):  
Flow Cytometry ◽  
T Lymphocytes ◽  
Lymphocyte Subsets ◽  
Healthy Individuals ◽  
Helper T Lymphocytes ◽  
Age Related ◽  
Healthy Donors ◽  
Adolescents And Adults ◽  
Age Related Changes ◽  
Th Lymphocytes

The dynamic process of the development of the immune system can in itself result in age-related immune malfunctions. In this study, we analysed lymphocyte subsets in the peripheral blood of 60 healthy donors, divided into groups of children, adolescents, and adults, focusing on effector (Teff) and regulatory (Treg) T lymphocytes and STAT1/STAT5 signalling response in helper T lymphocytes (Th) in adults, using flow cytometry. Our results demonstrate a decrease in the percentage of total Tregs and an increase in the percentage of total Teffs with age and a consequential immense increase in the Teff/Treg ratio. The increase of Teffs was most apparent in Th1, Th1Th17, and Th17CD161− subsets. Significant Th lymphocyte STAT1 expression differences were observed between children and adolescents, which were associated with the decrease in activated Tregs. Higher expression of STAT1 was found in FoxP3hi than in FoxP3low Th lymphocytes, while significant IL-2 induced STAT5 phosphorylation differences were found among the subsets of Th lymphocytes in adults. Our study demonstrates age-related changes in circulating Teff and Treg, as well as significant differences in STAT5/STAT1 signalling among FoxP3+ Th lymphocytes, providing new advances in the understanding of immunosenescence.

scholarly journals Age-related changes in topological organization of structural brain networks in healthy individuals

2011 ◽  
Vol 33 (3) ◽  
pp. 552-568 ◽  
Author(s):  
Kai Wu ◽  
Yasuyuki Taki ◽  
Kazunori Sato ◽  
Shigeo Kinomura ◽  
Ryoi Goto ◽  
...  
Keyword(s):  
Brain Networks ◽  
Healthy Individuals ◽  
Age Related ◽  
Topological Organization ◽  
Structural Brain ◽  
Age Related Changes

Age-Related Changes in Abdominal Pain in Healthy Individuals and IBS Patients

2017 ◽  
Vol 152 (5) ◽  
pp. S647 ◽  
Author(s):  
Ellen Wilms ◽  
Daisy Jonkers ◽  
Daniel Keszthelyi ◽  
Z. Mujagic ◽  
Lisa Vork ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Healthy Individuals ◽  
Age Related ◽  
Age Related Changes

Effects of strength training on muscle power and serum hormones in middle-aged and older men

2001 ◽  
Vol 90 (4) ◽  
pp. 1497-1507 ◽  
Author(s):  
M. Izquierdo ◽  
K. Häkkinen ◽  
J. Ibañez ◽  
M. Garrues ◽  
A. Antón ◽  
...  
Keyword(s):  
Strength Training ◽  
Muscle Power ◽  
Older Men ◽  
Analysis Of Covariance ◽  
Maximal Strength ◽  
Middle Aged ◽  
Total Strength ◽  
Leg Muscles ◽  
Age Related ◽  
Power Load

Effects of 16-wk strength training on maximal strength and power performance of the arm and leg muscles and serum concentrations [testosterone (T), free testosterone (FT), and cortisol] were examined in 11 middle-aged (M46; 46 ± 2 yr) and 11 older men (M64; 64 ± 2 yr). During the 16-wk training, the relative increases in maximal strength and muscle power output of the arm and leg muscles were significant in both groups ( P < 0.05–0.001), with no significant differences between the two groups. The absolute increases were higher ( P < 0.01–0.05) in M46 than in M64 mainly during the last 8 wk of training. No significant changes were observed for serum T and FT concentrations. Analysis of covariance showed that, during the 16-wk training period, serum FT concentrations tended to decrease in M64 and increase in M46 ( P < 0.05). However, significant correlations between the mean level of individual serum T and FT concentrations and the individual changes in maximal strength were observed in a combined group during the 16-wk training ( r = 0.49 and 0.5, respectively; P < 0.05). These data indicate that a prolonged total strength-training program would lead to large gains in maximal strength and power load characteristics of the upper and lower extremity muscles, but the pattern of maximal and power development seemed to differ between the upper and lower extremities in both groups, possibly limited in magnitude because of neuromuscular and/or age-related endocrine impairments.

scholarly journals Age-Related Changes of Pain Experience in Cerebral Palsy and Healthy Individuals

Pain Medicine ◽  
2011 ◽  
Vol 12 (4) ◽  
pp. 535-545 ◽  
Author(s):  
Inmaculada Riquelme ◽  
Ignacio Cifre ◽  
Pedro Montoya
Keyword(s):  
Cerebral Palsy ◽  
Healthy Individuals ◽  
Pain Experience ◽  
Age Related ◽  
Age Related Changes

scholarly journals Age-Related Changes of the Anticipatory Postural Adjustments During Gait Initiation Preceded by Vibration of Lower Leg Muscles

2021 ◽  
Vol 15 ◽  
Author(s):  
Jana Kimijanová ◽  
Diana Bzdúšková ◽  
Zuzana Hirjaková ◽  
František Hlavačka
Keyword(s):  
Older Adults ◽  
Sagittal Plane ◽  
Balance Control ◽  
The Elderly ◽  
Lower Leg ◽  
Anticipatory Postural Adjustments ◽  
The Body ◽  
Gait Initiation ◽  
Leg Muscles ◽  
Age Related

Gait initiation (GI) challenges the balance control system, especially in the elderly. To date, however, there is no consensus about the age effect on the anticipatory postural adjustments (APAs). There is also a lack of research on APAs in older adults after proprioceptive perturbation in the sagittal plane. This study aimed to compare the ability of young and older participants to generate APAs in response to the vibratory-induced perturbation delivered immediately before GI. Twenty-two young and 22 older adults performed a series of GI trials: (1) without previous vibration; (2) preceded by the vibration of triceps surae muscles; and (3) preceded by the vibration of tibialis anterior muscles. The APAs magnitude, velocity, time-to-peak, and duration were extracted from the center of pressure displacement in the sagittal plane. Young participants significantly modified their APAs during GI, whereas older adults did not markedly change their APAs when the body vertical was shifted neither backward nor forward. Significant age-related declines in APAs were observed also regardless of the altered proprioception.The results show that young adults actively responded to the altered proprioception from lower leg muscles and sensitively scaled APAs according to the actual position of the body verticality. Contrary, older adults were unable to adjust their postural responses indicating that the challenging transition from standing to walking probably requires higher reliance on the visual input. The understanding of age-related differences in APAs may help to design training programs for the elderly specifically targeted to improve balance control in different sensory conditions, particularly during gait initiation.

Age-related changes in liver, gall bladder and pancreas

2002 ◽  
Vol 12 (1) ◽  
pp. 12-20 ◽  
Author(s):  
Hilary A Wynne
Keyword(s):  
Liver Volume ◽  
Significant Negative Correlation ◽  
Post Mortem ◽  
Ultrasound Scanning ◽  
Healthy Individuals ◽  
Related Effect ◽  
Liver Size ◽  
Age Related ◽  
Age Related Changes

Although a reduced liver size in elderly people has long been recognized from post-mortem studies, these studies do not allow the separation of true ‘age-related’ differences from the effects of premorbid illness, and death. An age-related effect was confirmed however by an in vivo study which measured liver size by ultrasound scanning of healthy individuals. This demonstrated a significant negative correlation between age and liver volume, with volumes being 28% lower in individuals above the age of 65 compared with those under 40 years of age.

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