Age-Related Changes in Abdominal Pain in Healthy Individuals and IBS Patients

2017 ◽  
Vol 152 (5) ◽  
pp. S647 ◽  
Author(s):  
Ellen Wilms ◽  
Daisy Jonkers ◽  
Daniel Keszthelyi ◽  
Z. Mujagic ◽  
Lisa Vork ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Healthy Individuals ◽  
Age Related ◽  
Age Related Changes

scholarly journals Assessment of age-related changes of salivary immunoglobulin a levels among healthy individuals

2021 ◽  
Vol 13 (5) ◽  
pp. 461
Author(s):  
DipakBaliram Patil ◽  
ManishkumarDinkar Shete ◽  
Priyatam Karade ◽  
Rutuja Chopade ◽  
Neha Gandhi ◽  
...  
Keyword(s):  
Immunoglobulin A ◽  
Healthy Individuals ◽  
Age Related ◽  
Salivary Immunoglobulin A ◽  
Age Related Changes

scholarly journals Age-Related Differences in Percentages of Regulatory and Effector T Lymphocytes and Their Subsets in Healthy Individuals and Characteristic STAT1/STAT5 Signalling Response in Helper T Lymphocytes

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Marija Holcar ◽  
Aleš Goropevšek ◽  
Alojz Ihan ◽  
Tadej Avčin
Keyword(s):  
Flow Cytometry ◽  
T Lymphocytes ◽  
Lymphocyte Subsets ◽  
Healthy Individuals ◽  
Helper T Lymphocytes ◽  
Age Related ◽  
Healthy Donors ◽  
Adolescents And Adults ◽  
Age Related Changes ◽  
Th Lymphocytes

The dynamic process of the development of the immune system can in itself result in age-related immune malfunctions. In this study, we analysed lymphocyte subsets in the peripheral blood of 60 healthy donors, divided into groups of children, adolescents, and adults, focusing on effector (Teff) and regulatory (Treg) T lymphocytes and STAT1/STAT5 signalling response in helper T lymphocytes (Th) in adults, using flow cytometry. Our results demonstrate a decrease in the percentage of total Tregs and an increase in the percentage of total Teffs with age and a consequential immense increase in the Teff/Treg ratio. The increase of Teffs was most apparent in Th1, Th1Th17, and Th17CD161− subsets. Significant Th lymphocyte STAT1 expression differences were observed between children and adolescents, which were associated with the decrease in activated Tregs. Higher expression of STAT1 was found in FoxP3hi than in FoxP3low Th lymphocytes, while significant IL-2 induced STAT5 phosphorylation differences were found among the subsets of Th lymphocytes in adults. Our study demonstrates age-related changes in circulating Teff and Treg, as well as significant differences in STAT5/STAT1 signalling among FoxP3+ Th lymphocytes, providing new advances in the understanding of immunosenescence.

scholarly journals Age-related changes in topological organization of structural brain networks in healthy individuals

2011 ◽  
Vol 33 (3) ◽  
pp. 552-568 ◽  
Author(s):  
Kai Wu ◽  
Yasuyuki Taki ◽  
Kazunori Sato ◽  
Shigeo Kinomura ◽  
Ryoi Goto ◽  
...  
Keyword(s):  
Brain Networks ◽  
Healthy Individuals ◽  
Age Related ◽  
Topological Organization ◽  
Structural Brain ◽  
Age Related Changes

scholarly journals Age-Related Changes of Pain Experience in Cerebral Palsy and Healthy Individuals

Pain Medicine ◽  
2011 ◽  
Vol 12 (4) ◽  
pp. 535-545 ◽  
Author(s):  
Inmaculada Riquelme ◽  
Ignacio Cifre ◽  
Pedro Montoya
Keyword(s):  
Cerebral Palsy ◽  
Healthy Individuals ◽  
Pain Experience ◽  
Age Related ◽  
Age Related Changes

scholarly journals Age-Related Decrease in Abdominal Pain and Associated Structural- and Functional Mechanisms: An Exploratory Study in Healthy Individuals and Irritable Bowel Syndrome Patients

2021 ◽  
Vol 12 ◽  
Author(s):  
Abraham B. Beckers ◽  
Ellen Wilms ◽  
Zlatan Mujagic ◽  
Béla Kajtár ◽  
Kata Csekő ◽  
...  
Keyword(s):  
Young Adults ◽  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Visceral Hypersensitivity ◽  
Healthy Individuals ◽  
Intestinal Health ◽  
Healthy Elderly ◽  
Age Related ◽  
Underlying Mechanisms ◽  
Irritable Bowel

Introduction: The world population is ageing, resulting in increased prevalence of age-related comorbidities and healthcare costs. Limited data are available on intestinal health in elderly populations. Structural and functional changes, including altered visceroperception, may lead to altered bowel habits and abdominal symptoms in healthy individuals and irritable bowel syndrome (IBS) patients. Our aim was to explore age-related changes in gastrointestinal symptoms and underlying mechanisms.Methods: In total, 780 subjects (IBS patients n = 463, healthy subjects n = 317) from two separate studies were included. Subjects were divided into different age groups ranging from young adult to elderly. Demographics and gastrointestinal symptom scores were collected from all participants using validated questionnaires. A subset of 233 IBS patients and 103 controls underwent a rectal barostat procedure to assess visceral hypersensitivity. Sigmoid biopsies were obtained from 10 healthy young adults and 10 healthy elderly. Expression of the visceral pain-associated receptors transient receptor potential (TRP) Ankyrin 1 (TRPA1) and Vanilloid 1 (TRPV1) genes were investigated by quantitative RT-PCR and immunofluorescence.Results: Both elderly IBS and healthy individuals showed significantly lower scores for abdominal pain (p < 0.001) and indigestion (p < 0.05) as compared to respective young adults. Visceral hypersensitivity was less common in elderly than young IBS patients (p < 0.001). Relative TRPA1 gene transcription, as well as TRPA1 and TRPV1 immunoreactivity were significantly lower in healthy elderly versus healthy young adults (p < 0.05).Conclusions: Our findings show an age-related decrease in abdominal pain perception. This may in part be related to decreased TRPA1 and/or TRPV1 receptor expression. Further studies are needed to reveal precise underlying mechanisms and the associations with intestinal health.

Age-related changes in liver, gall bladder and pancreas

2002 ◽  
Vol 12 (1) ◽  
pp. 12-20 ◽  
Author(s):  
Hilary A Wynne
Keyword(s):  
Liver Volume ◽  
Significant Negative Correlation ◽  
Post Mortem ◽  
Ultrasound Scanning ◽  
Healthy Individuals ◽  
Related Effect ◽  
Liver Size ◽  
Age Related ◽  
Age Related Changes

Although a reduced liver size in elderly people has long been recognized from post-mortem studies, these studies do not allow the separation of true ‘age-related’ differences from the effects of premorbid illness, and death. An age-related effect was confirmed however by an in vivo study which measured liver size by ultrasound scanning of healthy individuals. This demonstrated a significant negative correlation between age and liver volume, with volumes being 28% lower in individuals above the age of 65 compared with those under 40 years of age.

scholarly journals Age-related changes in the effects of strength training on lower leg muscles in healthy individuals measured using MRI

2017 ◽  
Vol 3 (1) ◽  
pp. e000249 ◽  
Author(s):  
Maria Psatha ◽  
Zhiqing Wu ◽  
Fiona Gammie ◽  
Aivaras Ratkevicius ◽  
Henning Wackerhage ◽  
...  
Keyword(s):  
Strength Training ◽  
Lower Leg ◽  
Healthy Individuals ◽  
Leg Muscles ◽  
Age Related ◽  
Age Related Changes

Age-related changes in functional visual acuity in healthy individuals

2011 ◽  
Vol 55 (3) ◽  
pp. 183-189 ◽  
Author(s):  
Minako Kaido ◽  
Ikuko Toda ◽  
Reiko Ishida ◽  
Mototaka Konagai ◽  
Murat Dogru ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Healthy Individuals ◽  
Age Related ◽  
Functional Visual Acuity ◽  
Age Related Changes
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