Prospective observational study of medication reviews in internal medicine wards: evaluation of drug-related problems

2020 ◽  
pp. ejhpharm-2020-002492
Author(s):  
Lina Hellström ◽  
Tommy Eriksson ◽  
Åsa Bondesson
Keyword(s):  
Internal Medicine ◽  
Observational Study ◽  
Prospective Observational Study ◽  
Drug Related Problems ◽  
Medication Reviews ◽  
Internal Medicine Wards

scholarly journals DRUG-RELATED PROBLEMS AND ITS PRESCRIBING INDICATORS IN STROKE PATIENTS: A PROSPECTIVE OBSERVATIONAL STUDY

2021 ◽  
pp. 141-144
Author(s):  
DURGA PRASAD THAMMISETTY ◽  
DIVITI RANGANAYAKULU ◽  
DEVANNA NAYAKANTI
Keyword(s):  
Observational Study ◽  
Drug Interactions ◽  
Hospital Stay ◽  
Prospective Observational Study ◽  
Tertiary Care ◽  
World Health ◽  
Care Hospital ◽  
Drug Related Problems ◽  
Stroke Patients ◽  
Prescribing Indicators

Objective: The objective of the study was to assess the drug-related problems (DRPs) and the World Health Organization (WHO) core prescribing indicators among stroke patients. Methods: A prospective observational study was conducted among stroke inpatients of Acute Medical Care and General Medicine Department of a tertiary care hospital located in Tirupati, Andhra Pradesh, India. A suitable data collection form was used to collect the data about demographics, clinical characteristics, WHO prescribing indicators, and DRPs. Descriptive statistics were used to represent the demographics, distribution of DRPs, and prescribing indicators in the study. Chi-square test was employed to test the significant association between the demographics and the occurrence of DRPs. Results: Among 174 patients included in the study, 89 had one or more DRPs. A total of 122 DRPs were identified in the study population. Drug interactions (48.4%) and adverse drug reactions (ADRs) (17.2%) were commonly observed DRPs. A significant direct association was observed between the occurrence of DRPs and number of comorbidities (p<0.001), polypharmacy (p<0.001), and hospital stay (p<0.05). The average number of drugs per prescription was 7.2. Of drugs prescribed, 67.6% were in their generic names. The percentage of encounters in which an antibiotic, injection was prescribed was 65.5% and 89.6% respectively. The percentage of drugs prescribed from an essential drug list was 91.2%. Conclusion: The rate of drug interactions and ADRs was high in treatment of stroke patients. Patients suffering from comorbidities, polypharmacy, and long hospital stay were positively associated with occurrence of DRPs in stroke. Regular monitoring and screening for drug interactions and ADRs were advised to reduce the burden DRPs in stroke patients admitted in a critical care unit.

scholarly journals Drug-related problems and its determinant among hospitalized neonates with sepsis at Jimma University Medical Center, Ethiopia: a prospective observational study

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Mengist Awoke ◽  
Tsegaye Melaku ◽  
Mohammed Beshir
Keyword(s):  
Drug Therapy ◽  
Observational Study ◽  
Neonatal Intensive Care ◽  
Prospective Observational Study ◽  
Medical Center ◽  
Clinical Pharmacy Service ◽  
Drug Related Problems ◽  
Combined Use ◽  
Jimma University ◽  
Neonatal Population

Abstract Background Neonatal populations are quite susceptible to drug-related problems (DRPs) because of clinical heterogeneity and clinical practice trends. However, studies reporting DRPs in the neonatal population are quite limited. Objective This study aimed to assess the magnitude and types of DRPs and determinant factors among neonates admitted with neonatal sepsis at the Neonatal Intensive Care Unit (NICU) of the Jimma University Medical Center (JUMC), Ethiopia. Methods A hospital-based prospective observational study was conducted involving 201 neonates with sepsis admitted to the NICU from May to August 30, 2018. DRPs were classified using Cipolle’s classification method. Statistical Package for Social Science Version 22 was employed for data analysis. Logistical regression was carried out to determine the determinants of DRPs. A p-value < 0.05 was considered to be statistically significant. Results Of 201 neonates with sepsis included in this study, 125 (62.2%) were males and the median age of the neonate was 5 days. The mean (±standard deviation) number of medications taking during their hospital stay was 2.6 ± 0.7. DRPs were identified in 98 neonates, at a rate of 48.8% (95% CI, 41.7–55.9). Dose too high (42, 35.8%) and need additional drug therapy (40, 34.1%) were the commonly identified DRPs. Taking antibiotics plus other medications (Adjusted Odds Ratio (AOR) =5.2, 95%CI [1.2–22.0], p = 0.02) was a determinant factor for the occurrence of DRPs. Conclusion The burdens of DRPs occurrence were high in hospitalized neonates with sepsis. The most common DRPs identified were dose too high and need additional drug therapy. Combined use of other medicines with antibiotics was a predictor of DRP occurrence. The innovative way to tackle the occurrence of DRPs, such as the incorporation of clinical pharmacy service provider into the neonatal care team, which will prevent, detect and/or minimize the occurrence of DRPs, is highly recommended.

Orthostatic hypotension among elderly patients in Italian internal medicine wards: an observational study

2019 ◽  
Vol 15 (2) ◽  
pp. 281-287 ◽  
Author(s):  
Luca Pasina ◽  
Monica Casati ◽  
Laura Cortesi ◽  
Mauro Tettamanti ◽  
Ramona Pellegrini ◽  
...  
Keyword(s):  
Internal Medicine ◽  
Observational Study ◽  
Elderly Patients ◽  
Orthostatic Hypotension ◽  
Internal Medicine Wards

Actual drug–drug interactions in elderly patients discharged from internal medicine clinic: a prospective observational study

2013 ◽  
Vol 69 (9) ◽  
pp. 1717-1724 ◽  
Author(s):  
Srecko Marusic ◽  
Vesna Bacic-Vrca ◽  
Paulo Roque Obreli Neto ◽  
Miljenko Franic ◽  
Viktorija Erdeljic ◽  
...  
Keyword(s):  
Internal Medicine ◽  
Observational Study ◽  
Elderly Patients ◽  
Drug Interactions ◽  
Prospective Observational Study ◽  
Medicine Clinic ◽  
Internal Medicine Clinic

scholarly journals Identification and resolution of drug-related problems among diabetic patients attending a referral hospital: a prospective observational study

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Tadesse Sheleme ◽  
Tamiru Sahilu ◽  
Desalegn Feyissa
Keyword(s):  
Observational Study ◽  
Drug Treatment ◽  
Prospective Observational Study ◽  
Diabetes Duration ◽  
Referral Hospital ◽  
Multivariable Logistic Regression Analysis ◽  
Diabetic Patients ◽  
Drug Related Problems ◽  
Contributing Factors ◽  
Observational Study Design

Abstract Background People living with diabetes are more vulnerable to drug-related problems due to the presence of multiple diseases. This study aimed to identify drug-related problems and contributing factors among diabetic patients. Methods This study used a prospective observational study design. The study was conducted among diabetic patients during follow-up at Mettu Karl Referral Hospital from 15 April to 09 August 2019. The consecutive sampling was utilized to collect data. The identification of drug-related problems was performed using the Pharmaceutical Care Network Europe version 8.03. Following data collection, data were entered into Epidata manager version 4.4.2 and exported to the SPSS version 24.0 for analysis. Multivariable logistic regression analysis was done to identify predictors of drug-related problems. Results A total of 330 people with diabetes were included in the study, among whom 279 (84.5%) had at least one drug-related problem. A total of 455 drug-related problems were identified. Effects of drug treatment not being optimal (52.7%) and untreated symptoms or indications (30.1%) were the most commonly identified drug-related problems. About 865 interventions were provided for identified drug-related problems and 79.8% was accepted. Diabetes duration $$\ge 7$$ ≥ 7  years [AOR = 2.02; 95% CI (1.06, 3.85); p = 0.033] and the presence of comorbidity [AOR: 2.33; 95% CI (1.18, 4.60); p = 0.015] were factors identified as predictors of drug-related problems. Conclusion The present study identified that drug-related problems are common among diabetic patients. Effects of drug treatment not being optimal and untreated symptoms or indications were the most commonly identified drug-related problems. Longer diabetes duration and the presence of comorbidities were predictors of drug-related problems.

scholarly journals Drug-related problems among patients with infectious disease admitted to medical wards of Wollega University Referral Hospital: Prospective observational study

2021 ◽  
Vol 9 ◽  
pp. 205031212198962
Author(s):  
Firomsa Bekele ◽  
Ginenus Fekadu ◽  
Kumera Bekele ◽  
Dinka Dugassa ◽  
Jiregna Sori
Keyword(s):  
Infectious Disease ◽  
Drug Therapy ◽  
Observational Study ◽  
Prospective Observational Study ◽  
Referral Hospital ◽  
Clinical Pharmacy Service ◽  
Drug Related Problems ◽  
Disease Etiology ◽  
Co Morbidity ◽  
Medical Wards

Introduction: Drug-related problems can affect the treatment outcomes of hospitalized patients and outpatients that lead to morbidity and mortality. Despite this, there were scanty of studies among patients with infectious diseases in Ethiopia. As the result, this study was tried to assess the magnitude and determinants of drug therapy problems among infectious disease patients admitted to the medical wards of Wollega University Referral Hospital. Methods: A prospective observational study was conducted from May to August 2019. The prevalence and types of drug- related therapy problems were studied using the Pharmaceutical Care Network Europe Foundation classification system, and adverse drug reaction was assessed by using the Naranjo algorithm. Multivariable logistic regression analysis was used to determine the predictors of drug-related problems, and a significant association was declared if p-value < 0.05. Result: Of the 172 study participants, 106 (61.6%) were males, and the patient’s mean age was 39.1 ± 14.31 years. Over the study period, 123 (71.51%) patients had drug-related problems. Need for additional drug therapy was the widely occurred drug-related problem that accounts for 107 (22.77%), and the most common drug-associated with the drug therapy problem was ceftriaxone (77 (44.77%)). This inappropriate use of ceftriaxone might be due to the preference of physicians to prescribe this broad spectrum antibiotic in which it was prescribed for the majority of the infectious disease etiology. Polypharmacy (adjusted odds ratio (AOR) = 2.505, 95% confidence interval (CI): 1.863–11.131), length of hospital stay ⩾ 7 days (AOR = 4.396, 95% CI: 1.964–7.310), and presence of co-morbidity (AOR = 2.107, 95% CI: 1.185–4.158, p = 0.016) were determinants of drug-related problems. Conclusion: The magnitude of drug-related problems was found to be high. Hence, the clinical pharmacy service should be established to tackle inappropriate indications, ineffective drug therapy, and adverse drug events in the study area.

scholarly journals A PROSPECTIVE OBSERVATIONAL STUDY ON THE INCIDENCE OF DRUG-RELATED HOSPITAL ADMISSIONS IN A TERTIARY CARE HOSPITAL

2021 ◽  
pp. 56-59
Author(s):  
AKSHAY TL ◽  
ALAKA PRAKASH ◽  
ASHIQ MOHAMED ANAS M ◽  
DIWAHAR S ◽  
RAMA P
Keyword(s):  
Risk Factor ◽  
Observational Study ◽  
Prospective Observational Study ◽  
Hospital Admissions ◽  
Tertiary Care ◽  
Care Hospital ◽  
Drug Related Problems ◽  
The People ◽  
Causative Drug ◽  
Significant Burden

Objectives: The objective of the study is to identify the incidence of drug-related problems coming to the EMD, classify, and identify the risk factor for DRP. Methods: This was a prospective observational study conducted in the emergency department for a period of 6 months. The patients admitted through EMD with DRP were identified and then were classified according to Hepler and Strand, 1990 and Classen et al., 1997. Results: A total of 109 patients were identified with DRP in our study. Among them, major part was contributed by ADRs (69.7%), non-adherence (27.5%) followed by sub-therapeutic dosage, and untreated indication and overdosage (0.91%). The major organ system involved in DRPs was found to be neurological system (26.60%) and gastrointestinal system (23.85%). The major causative drug class for DRP was found to be anti-thrombotic agents (27%), and the major risk factor for the development of DRP was found to be polypharmacy. Conclusion: Drug-related problems are becoming one of the major reasons for the EMD admissions in the hospitals. It can cause significant burden to the society and to the health of the people.

Sign in / Sign up

Export Citation Format

Share Document