scholarly journals Anticholinergic medications even in therapeutic range can cause recurrence of psychosis

2020 ◽  
Vol 33 (4) ◽  
pp. e100235
Author(s):  
Soumitra Das ◽  
Seshadri Sekhar Chatterjee ◽  
Barikar Chandrappa Malathesh
Keyword(s):  
Special Reference ◽  
Therapeutic Range ◽  
Side Effect ◽  
Young Female ◽  
Anticholinergic Drugs ◽  
Extrapyramidal Syndrome ◽  
Anticholinergic Medications ◽  
Normal Cognition

Anticholinergic drugs are commonly used in psychiatry to attenuate antipsychotic induced extrapyramidal syndrome (EPS). Psychosis as a side effect is generally explained under the rubric of anticholinergic toxicity or induced delirium. Anticholinergic induced worsening of psychosis in patients with normal cognition is extremely rare in literature. Here, we arepresenting a case of young female who was prescribed with multiple anticholinergics to reduce EPS, and each time had worsening of psychosis with intact cognition. We then discussed the possible neurobiological explanation with special reference to muscarinic hypothesis of schizophrenia.

Structure Side-Effect Sorting of Drugs I: Extrapyramidal Syndrome

1973 ◽  
Vol 62 (4) ◽  
pp. 645-647 ◽  
Author(s):  
Eric J. Lien ◽  
Gedy A. Gudauskas
Keyword(s):  
Side Effect ◽  
Extrapyramidal Syndrome

The False Drug Side-Effect: Which Patients Complain

1968 ◽  
Vol 114 (507) ◽  
pp. 197-201 ◽  
Author(s):  
William S. Appleton
Keyword(s):  
Mental Health ◽  
Side Effects ◽  
Health Center ◽  
Side Effect ◽  
Mental Health Center ◽  
Young Female ◽  
Need For Care ◽  
Drug Induced ◽  
Medication Side Effect ◽  
Medication Side

At the Massachusetts Mental Health Center (M.M.H.C.), a well-staffed university psychiatric hospital, an outbreak of alleged chlorpromazine-induced skin rashes recently occurred involving five dramatic young female patients. Investigation of the complaints led us to doubt whether medication was the cause. Why then did these women blame chlorpromazine? Thus, the central concern of this investigation: which patients are likely to complain of drug-induced side-effects and under what conditions? A second issue arising from our study and described in the literature is the need for care when differentiating the true from the alleged medication side-effect.

scholarly journals "A clinical study of ‘bilva patra kwath avagahan sweda’ in the management of arsha in garbhini with special reference to 1st And 2nd-degree internal hemorrhoids."

2017 ◽  
Vol 5 (5) ◽  
Author(s):  
Rajendra M. Sonekar ◽  
Sagar D. Chandane ◽  
Aruna Sonekar
Keyword(s):  
Clinical Study ◽  
Special Reference ◽  
Surgical Procedures ◽  
Side Effect ◽  
Proper Time ◽  
Internal Sphincter ◽  
Signs And Symptoms ◽  
Sitz Bath ◽  
Internal Hemorrhoids ◽  
In Pregnancy

Haemorrhoids are uncomfortable, very common during pregnancy due to various causes. The haemorrhoidal plexus get dilated and inflamed resulting in formation of haemorrhoids. If not treated at proper time may cause bleeding and protrusion of the haemorrhoids. In such a condition, surgical and para-surgical procedures have limitations and use of internally ushna and tikshna kalpas are contraindicated in Garbhini. Keeping in view these problems BILVA Patra Kwath Avgahan sweda karma in Charak Chikitsa sthana - 14/47 was selected to evaluate the effect of Avgahan sweda karma in relieving the signs and symptoms of haemorrhoids. Bilva patra kwath sitz bath was given to the GARBHINI patient suffering from haemorrhoids. Present study has been done on 10 patients and an effort has been made to derive safe, easy accessible treatment in pregnancy. A BILVA patra kwath Avgahan sweda, which has proven Anti-inflammatory7 property relieves venous congestion, relieves spasm of internal sphincter muscles. Assessment done on the basis of criteria, resulting into PR bleeding and significant reduction in size of piles mass without any untoward side effect in pregnancy.

scholarly journals Isolated Lingual Dystonia as the Manifestation of Acute Extrapyramidal Syndrome Induced by Metoclopramide

2019 ◽  
Vol 10 (02) ◽  
pp. 346-348 ◽  
Author(s):  
Rajesh Verma ◽  
Chetan Shettigar
Keyword(s):  
Oral Cavity ◽  
Movement Disorder ◽  
Masticatory Muscles ◽  
Young Female ◽  
Oromandibular Dystonia ◽  
Rare Form ◽  
Extrapyramidal Syndrome ◽  
Lingual Dystonia ◽  
Hyperkinetic Movement Disorder ◽  
The Common

ABSTRACTOromandibular dystonia is characterized by persistent contractions and repetitive spasms of masticatory muscles surrounding the oral cavity and lingual muscles. The lingual dystonia is rare hyperkinetic movement disorder, often occurring secondary to drugs. The common drugs which can cause acute focal dystonia are neuroleptics, antiemetics, and antipsychotics. Isolated lingual dystonia is a rare form of disabling focal dystonias. We report a young female, who developed tongue dystonia in isolation and responding favorably to antihistaminics. The physicians are advised to make inquiry about administered drugs in isolated lingual dystonia.

scholarly journals S-B-8. Side Effect of Bilateral CEM-Thalamotomy with Special Reference to Transient Disturbance of Consciousness

1967 ◽  
Vol 9 ◽  
pp. 304-304
Author(s):  
Miyoshi URABE ◽  
Takashi TSUBOKAWA ◽  
Makoto KIKUCHI ◽  
Satoru KADOYA ◽  
Yoh WATANABE ◽  
...  
Keyword(s):  
Special Reference ◽  
Side Effect ◽  
Disturbance Of Consciousness

Bradycardia Due to Trihexyphenidyl Hydrochloride

1986 ◽  
Vol 20 (10) ◽  
pp. 786-787 ◽  
Author(s):  
Rachel Blumensohn ◽  
Gideon Razoni ◽  
Amieh Shalev ◽  
Herman Munitz
Keyword(s):  
Schizophrenic Patient ◽  
Side Effect ◽  
Sinus Bradycardia ◽  
Anticholinergic Drug ◽  
Psychiatric Practice ◽  
Anticholinergic Drugs ◽  
Chronic Schizophrenic ◽  
Chronic Schizophrenic Patient

A chronic schizophrenic patient was treated with an anticholinergic drug, trihexyphenidyl hydrochloride. The patient developed, paradoxically, sinus bradycardia. The reaction was specific to trihexyphenidyl and not to other anticholinergic drugs. This antidyskinetic drug is widely used in clinical psychiatric practice and physicians should be aware of this side effect.

scholarly journals Treatment of antipsychotic-induced parkinsonism in schizophrenic patients

2021 ◽  
Vol 13 (4) ◽  
pp. 4-11
Author(s):  
E. E. Vaiman ◽  
N. A. Shnayder ◽  
N. G. Neznanov ◽  
R. F. Nasyrova
Keyword(s):  
Web Of Science ◽  
Neurological Complications ◽  
Anticholinergic Drugs ◽  
Extrapyramidal Syndrome ◽  
Receptor Agonists ◽  
The Past ◽  
Melatonin Receptor Agonists ◽  
Schizophrenic Patients ◽  
The Russian Federation ◽  
Limited Choice

Antipsychotic-induced parkinsonism (AIP) is one of the prognostically unfavorable complications of psychopharmacotherapy in patients with schizophrenia. Many studies have investigated various drugs that are used to treat this neurological side effect. This review analyzes drugs that are used and may be perspective for the treatment of AIP. We searched for full-text publications in Russian and English in the following databases: E-Library, PubMed, Web of Science, Springer, using keywords and combined word searches over the past decade (2011—2020). The review covers drugs that are promising for the correction of AIP, including anticholinergic drugs; NMDA receptor antagonists; dopamine receptor agonists; selective inhibitors of monoamine oxidase B; catecholamine transferase inhibitors; melatonin preparations; melatonin receptor agonists; benzodiazepines; herbal preparations traditionally used for the prevention and correction of extrapyramidal syndrome of various etiologies. Currently, a small number of medications are used in clinical practice for the treatment of AIP. However, not all of them are registered in the Russian Federation. Along with the differences in the mechanisms of AIP pathogenesis in specific patients, the limited choice of AIP treatments makes it difficult to solve the problem of adverse neurological complications of psychopharmacotherapy in schizophrenia.

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