Diarrhoea and massive duodenal round cell infiltration in a 27-year-old HIV positive female

Gut ◽  
2011 ◽  
Vol 60 (11) ◽  
pp. 1486-1486
Author(s):  
C. Neufert ◽  
A. Agaimy ◽  
J. Wacker ◽  
H. Neumann ◽  
M. F. Neurath ◽  
...  
Keyword(s):  
Cell Infiltration ◽  
Hiv Positive ◽  
Round Cell ◽  
Round Cell Infiltration

scholarly journals Pathology of rats intranasally inoculated with the cilia-associated respiratory bacillus

1989 ◽  
Vol 23 (2) ◽  
pp. 89-95 ◽  
Author(s):  
S. Matsushita ◽  
H. Joshima
Keyword(s):  
Lamina Propria ◽  
Clinical Signs ◽  
Body Weight Loss ◽  
Experimental Period ◽  
Immunofluorescence Assay ◽  
Cell Infiltration ◽  
Respiratory Pathogens ◽  
Round Cell ◽  
Round Cell Infiltration ◽  
Gross Lesions

Five-week-old Wistar/Ms rats were inoculated intranasally with a lung homogenate containing a strain of cilia-associated respiratory (CAR) bacillus and were examined on days 4, 7, 14, 21, 28 and 56 postinoculation (PI). Some rats showed clinical signs with wheezing and considerable body weight loss from day 21 PI. Gross lesions, including enlargement of lungs with focal atelectasis, bronchiectasis and emphysema, were observed from day 21 PI. Histologically, round cell infiltration was first present in the lamina propria of the nasal respiratory mucosa on day 7 PI. From day 14 PI, colonization of the CAR bacillus (4-8 µm in length), associated with round cell infiltration in the lamina propria and the peripheral regions, was observed in the ciliated mucosa of the bronchioles, bronchi, trachea and nasal cavities. Generally, the lesions progressed and expanded from upper to lower airways with time. Sporadic mucopurulent bronchopneumonia was observed from day 21 PI in some rats. The CAR bacilli (0·2-0·25 µm in diameter) were also demonstrated electron-microscopically in the ciliated epithelium of the intrapulmonary airways. The CAR bacillus antigen was demonstrated on the ciliated mucosa of the affected airways by the indirect immunofluorescence assay technique. Microbiological examination revealed that the rats used in this study were free from other known respiratory pathogens throughout the experimental period. Thus, it is suggested that the CAR bacillus alone can produce a murine respiratory disease. Fourteen days were needed for pathological lesions to develop.

Round Cell Infiltration

1949 ◽  
Vol 19 (4) ◽  
pp. 393-393 ◽  
Author(s):  
S. M. Rabson
Keyword(s):  
Cell Infiltration ◽  
Round Cell ◽  
Round Cell Infiltration

scholarly journals SWINE INFLUENZA

1931 ◽  
Vol 54 (3) ◽  
pp. 349-359 ◽  
Author(s):  
Richard E. Shope
Keyword(s):  
Swine Influenza ◽  
Bronchial Epithelium ◽  
Cell Infiltration ◽  
General Distribution ◽  
Round Cell ◽  
Pulmonary Atelectasis ◽  
Round Cell Infiltration ◽  
Splenic Tumor ◽  
Intranasal Instillation ◽  
Experimental Disease

Swine influenza has been induced in pigs by the intranasal instillation of material from spontaneous cases of the disease as occurring epizootically in eastern Iowa. The experimental disease has the same features as the epizootic. It has been maintained for study by serial passages accomplished either by intranasal instillation or by pen contact. Eight strains of the virus have been established experimentally during three epizootic periods. The clinical disease induced by these eight strains has been in general the same although its severity and mortality have varied. The principal features of the pathology of swine influenza are an exudative bronchitis accompanied by marked damage of the bronchial epithelium and its cilia, a peribronchial round cell infiltration, and massive pulmonary atelectasis. The latter is modified somewhat by a round cell infiltration of the alveolar walls. The lymph nodes, especially the cervical and mediastinal ones, are hyperplastic and edematous. There is usually a mild to moderate, acute splenic tumor. The mucosa of the stomach and colon is congested. The pneumonia following swine influenza is, characteristically, lobular in type and of the same general distribution as the atelectasis. The non-pneumonic areas of lung are extremely edematous and congested.

scholarly journals STUDIES IN TISSUE SPECIFICITY

1914 ◽  
Vol 19 (2) ◽  
pp. 181-186 ◽  
Author(s):  
James B. Murphy
Keyword(s):  
Connective Tissue ◽  
Cell Infiltration ◽  
Polymorphonuclear Cells ◽  
Round Cell ◽  
Adult Chicken ◽  
Connective Tissue Capsule ◽  
Round Cell Infiltration ◽  
The One ◽  
Rat Tumors ◽  
Tissue Capsule

Rat tumors and other tissues of foreign species grow actively in the chick embryo until the onset of a refractory period. Grafts of rat sarcoma established and growing actively at the onset of this period show a rapid cessation of growth between the 18th and 19th days of incubation. This is followed by a widespread degeneration of the rat cells and a marked activity of the connective tissue elements in the embryonal tissue round about. An occasional specimen may show small mononuclear infiltration or rarely accumulations of polymorphonuclear cells in the neighborhood of the strange tissue. During the 20th and 21st days the connective tissue capsule increases rapidly, invading the graft and replacing it. The foreign cells disintegrate rapidly and by the 22d day have practically all disappeared. The period at which the established graft begins to degenerate, namely the 19th to the 20th day of incubation, is the one on which grafts of foreign tissue will no longer take when implanted in the embryo. The cells at the edge of the graft of foreign tissue survive for a time. There is a rapid formation of a connective tissue capsule and an invasion of the grafts. The foreign cells here practically all have disappeared by the 22d day, leaving a mass of connective tissue. The absence of a round cell infiltration is the most marked difference in the process in the embryo as compared with that in the adult chicken. The process about the grafts in newly hatched chicks is characterized by a more active response of the connective tissue than in the adult and a more pronounced round cell infiltration than in the embryo.

scholarly journals A PATHOLOGICAL STUDY OF SYPHILITIC AORTITIS AND ITS SEROLOGY

1916 ◽  
Vol 23 (1) ◽  
pp. 25-38 ◽  
Author(s):  
John H. Larkin ◽  
I. J. Levy
Keyword(s):  
Guinea Pig ◽  
Inflammatory Process ◽  
Alcoholic Extract ◽  
Round Cell ◽  
Pathological Study ◽  
Guinea Pig Heart ◽  
Histological Changes ◽  
Round Cell Infiltration ◽  
Constant Feature ◽  
Syphilitic Aortitis

1. Syphilitic aortitis is a productive inflammatory process, the earliest and most constant feature of which is a perivascular round cell infiltration in the adventitia. 2. The typical gross picture of luetic aortitis is often obscured by a superimposed, diffuse atherosclerosis. In the early cases the aorta appears fairly normal, presenting only the characteristic histological changes. 3. A pure aortic insufficient valve, with the exception of an infectious endocarditis, is always luetic. 4. Cardiac hypertrophy is not a complication of luetic aortitis. When present it is usually associated with a nephritis. 5. The demonstration of Spirochœta pallida, even in advanced specimens of syphilitic aortas, is doubtful. 6. An antigen prepared from alcoholic extract of guinea pig heart with the original Wassermann technique should be preferred in diagnosing luetic aortitis. 7. Positive complement fixations in patients suffering with syphilis for a period of about fifteen years or longer suggest the probability, at least, of histological luetic changes in the aorta in 80 to 90 per cent of the cases. 60 per cent of these die from aortitis. 8. About 94 per cent of patients suffering with aortitis give positive Wassermann reactions.

scholarly journals THE ROLE OF PENICILLIN-INDUCED BACTERIAL VARIANTS IN EXPERIMENTAL PYELONEPHRITIS

1967 ◽  
Vol 125 (4) ◽  
pp. 607-618 ◽  
Author(s):  
Richard H. Winterbauer ◽  
Laura T. Gutman ◽  
Marvin Turck ◽  
Ralph J. Wedgwood ◽  
Robert G. Petersdorf
Keyword(s):  
Escherichia Coli ◽  
Renal Medulla ◽  
Round Cell ◽  
Histologic Response ◽  
E Coli ◽  
Round Cell Infiltration ◽  
Kidney Liver

1. After injection into the renal medulla of rats Escherichia coli 06 variants reverted rapidly in vivo in the absence of penicillin. These variants had previously been shown to be stable in vitro. 2. Variants failed to survive following intramedullary injection when animals were receiving penicillin. 3. Late reversion of variants also failed to occur in animals treated with penicillin for only 1 or 2 days. 4. Variants survived and reverted more readily when injected in the renal medulla, compared with liver and spleen. Classical bacteria injected into the kidney, liver, and spleen were recovered in approximately equal numbers. 5. The histologic response to nonreverting variants, medium not containing variants, and killed variants was similar and was characterized by a fibrotic reaction with moderate round cell infiltration. 6. In contrast, the histologic response to reverting variants and to classical E. coli was characterized by an intense, acute, polymorphonuclear leukocytosis typical of acute pyelonephritis.

Fixed Drug Eruption Caused by Tosufloxacin Tosilate

1997 ◽  
Vol 25 (6) ◽  
pp. 359-363 ◽  
Author(s):  
S Nishijima ◽  
M Nakagawa
Keyword(s):  
Skin Lesion ◽  
Common Cold ◽  
Drug Eruption ◽  
Histopathological Examination ◽  
Round Cell ◽  
Fixed Drug Eruption ◽  
Provocation Tests ◽  
Round Cell Infiltration ◽  
Published Report ◽  
Fixed Drug

A 39-year-old woman presented with a purple-red macula, 2 cm in diameter, on the back of her right hand. She had had similar maculae at this location several times before and residual pigmentation had persisted for 6 months. Histopathological examination showed slight acanthosis of the epidermis and perivascular round-cell infiltration and melanophages in the dermis. Oral provocation tests with five drugs that the patient had received as common-cold treatments on different occasions were positive only in the case of tosufloxacin; after an hour the skin lesion reappeared. To our knowledge this is the first published report of a fixed drug eruption caused by tosufloxacin, although such eruptions have previously been reported for several other fluoroquinolones.

scholarly journals THE EFFECT OF 6-MERCAPTOPURINE AND AMINOPTERIN ON EXPERIMENTAL IMMUNE THYROIDITIS IN GUINEA PIGS

1963 ◽  
Vol 118 (5) ◽  
pp. 869-890 ◽  
Author(s):  
Hans L. Spiegelberg ◽  
Peter A. Miescher
Keyword(s):  
Immune Response ◽  
Guinea Pigs ◽  
Antibody Formation ◽  
Delayed Hypersensitivity ◽  
Round Cell ◽  
Thyroid Extract ◽  
Immune Disease ◽  
Time Intervals ◽  
Round Cell Infiltration ◽  
Discontinuation Of Treatment

The influence of 6-mercaptopurine and aminopterin was studied on immune response and immune thyroiditis in guinea pigs immunized with thyroid extract. 1. Both compounds depressed delayed hypersensitivity to thyroglobulin and immune thyroiditis. 2. Antibody formation to thyroglobulin was strongly depressed by aminopterin but not significantly influenced by 6-mercaptopurine. 3. Immune response and thyroiditis were suppressed as long as the compounds were administered; after discontinuation of treatment, immune response and thyroiditis appeared in the same time intervals as observed in control animals after initiation of immunization. 4. Treatment with 6-mercaptopurine and aminopterin 10 days after immunization lead to suppression of delayed hypersensitivity and thyroiditis. 5. Treatment with 6-mercaptopurine of animals after onset of thyroiditis lead to suppression of delayed hypersensitivity and disappearance or diminution of round cell infiltration in the thyroid. 6. The results are discussed in terms of the pathogenesis of experimental immune thyroiditis, the mode of action of these antimetabolites on this experimental immune disease, and in view of the potential value of these compounds in human diseases.

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