scholarly journals Autoimmune hepatitis: a histological variant associated with prominent centrilobular necrosis

Gut ◽  
1997 ◽  
Vol 41 (2) ◽  
pp. 269-271 ◽  
Author(s):  
H S Te ◽  
G Koukoulis ◽  
D R Ganger
Keyword(s):  
Liver Biopsy ◽  
Autoimmune Hepatitis ◽  
Steroid Therapy ◽  
Biopsy Specimen ◽  
Hepatitis A ◽  
Liver Biopsy Specimen ◽  
Centrilobular Necrosis ◽  
Histological Appearance ◽  
Histological Variant ◽  
Portal Tracts

A patient presented with pruritus and recent elevation of aminotransferases. The case fulfilled most of the criteria for the diagnosis of autoimmune hepatitis and achieved clinical and complete biochemical response to steroid therapy. However, the liver biopsy specimen revealed an unusual histological pattern consisting of severe centrilobular necrosis demarcated by a thin rim of hepatitic reaction. In contrast, the portal tracts appeared almost normal. This histological appearance has not been associated with autoimmune hepatitis. This presentation and the histology may represent an early pattern of autoimmune injury to the liver.

scholarly journals A case of Autoimmune Hepatitis needed to be differentiated from EBV hepatitis, in that the histology of liver biopsy specimen was useful for diagnosis

2005 ◽  
Vol 28 (3) ◽  
pp. 154-158 ◽  
Author(s):  
Shoko NAKAJIMA ◽  
Hiroaki UMEBAYASHI ◽  
Rumiko KUROSAWA ◽  
Tomoyuki IMAGAWA ◽  
Shigeki KATAKURA ◽  
...  
Keyword(s):  
Liver Biopsy ◽  
Autoimmune Hepatitis ◽  
Biopsy Specimen ◽  
Liver Biopsy Specimen

scholarly journals A case of argininosuccinate synthetase(ASS) deficiency diagnosed by the measurement of ASS with the liver biopsy specimen.

1989 ◽  
Vol 78 (9) ◽  
pp. 1339-1343
Author(s):  
Shigeki MORI ◽  
Yutaka AOYAGI ◽  
Takashi OHNO ◽  
Toshiaki WATANABE ◽  
Minoru NOMOT ◽  
...  
Keyword(s):  
Liver Biopsy ◽  
Biopsy Specimen ◽  
Argininosuccinate Synthetase ◽  
Liver Biopsy Specimen

Do the needle type and the operator experience influence liver biopsy specimen quality?

Open Medicine ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. 669-673
Author(s):  
Ioan Sporea ◽  
Alina Popescu ◽  
Mircea Focşa ◽  
Gabriel Becheanu ◽  
Roxana Şirli ◽  
...  
Keyword(s):  
Liver Biopsy ◽  
Biopsy Specimen ◽  
Liver Biopsy Specimen ◽  
Operator Experience ◽  
Needle Type ◽  
Specimen Quality

Abstract

The Microheterogeneity of Human Liver and Serum Ferritins Measured on Minute Amounts of Ferritin in Crude Samples

1984 ◽  
Vol 21 (6) ◽  
pp. 471-476 ◽  
Author(s):  
F M J Zuyderhoudt ◽  
C Linthorst
Keyword(s):  
Liver Biopsy ◽  
Iron Overload ◽  
Liver Tissue ◽  
Biopsy Specimen ◽  
Unknown Origin ◽  
Enzyme Linked Immunosorbent Assay ◽  
Liver Biopsy Specimen ◽  
Tissue Samples ◽  
Ferritin Concentration ◽  
Biopsy Specimens

A method is presented to measure the microheterogeneity of ferritin in μg amounts, without purifying the samples extensively. Ferritin-containing samples such as serum and homogenized liver-biopsy specimens were mixed with Sephadex G-75 and ampholines. Isoelectric focussing was performed and the pH gradient in the Sephadex was measured. The Sephadex was divided into predetermined pH ranges and the ferritin eluted from these fractions. Ferritin concentration was measured by an enzyme-linked immunosorbent assay. The method proved to be reproducible. The isoferritin profiles of different human serum and liver tissue samples were quite variable. In most cases serum ferritins focussed between approximately pH 5·5 and pH 4·9 and liver ferritins between approximately pH 5·8 and pH 5·3. We examined whether there was a similarity in the isoferritin patterns of serum and liver of distinct patients. We also studied liver tissue and serum from a patient with haemochromatosis and from a child with iron overload of unknown origin. In the serum of our patients the isoferritin pattern had shifted to lower pI when compared with that found in liver tissue. Only in the case of a patient with transfusion iron overload were basic isoferritins measured in the serum. In this case no liver biopsy specimen was available for comparison.

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