Tu1009 Evaluation of Liver Biopsy Practice Revealed That Ultrasound Guided Liver Biopsy Using 14G Liver Biopsy Needle Can Provide Adequate Liver Biopsy Specimen and a Safe Procedure Without Complications

2012 ◽  
Vol 142 (5) ◽  
pp. S-1009
Author(s):  
Saravanan Arjunan ◽  
Nik Raihan ◽  
Muhammad Radzi ◽  
Kiew Kuang Kiat ◽  
Zainuddin Zalwani ◽  
...  
Keyword(s):  
Liver Biopsy ◽  
Biopsy Specimen ◽  
Safe Procedure ◽  
Liver Biopsy Specimen ◽  
Ultrasound Guided ◽  
Biopsy Needle

scholarly journals Increased Needle Visibility in Ultrasound-Guided Percutaneous Liver Biopsy by an Echogenic Sheath: A Proof of Concept Study in a Human Cadaver

2021 ◽  
Author(s):  
Jana S. Hopstaken ◽  
Leon de Jong ◽  
Jurgen J. Fütterer
Keyword(s):  
Pilot Study ◽  
Liver Biopsy ◽  
Human Cadaver ◽  
Percutaneous Liver Biopsy ◽  
Ultrasound Guided ◽  
Biopsy Needle ◽  
Phantom Model ◽  
Likert Score ◽  
Contrast Analysis ◽  
Needle Visibility

Abstract Purpose For the safety and success of an ultrasound-guided percutaneous liver biopsy, needle visibility and needle tip identification are critical. The aim of this pilot study was to evaluate the influence of an innovative echogenic sheath placed over a standard biopsy needle on needle visibility in ultrasound imaging. Materials and methods Ultrasound videos of three sheaths with different coating characteristics (echogenicity) and one conventional liver biopsy needle were recorded at two angles (30° and 60°) and two depths (5 and 10 cm) in a human cadaver. The videos were blinded for needle type and presented to five independent radiologists who used Likert-scale scoring to rank each video for six characteristics on needle visibility. In addition, a phantom model was used to acquire standardized images for quantitative evaluation of the ultrasound visibility. Comparative statistical analysis consisted of a one-way ANOVA. Results The three prototype sheaths were ranked higher than the control needle at 60° with 5 cm depth, with an equal performance for the other conditions. The radiologists expressed more confidence in taking a biopsy with the echogenic sheaths than with the control needle, with 1 Likert score difference at 30°. Contrast analysis in the phantom model showed a statistically significant effect of a sheath (p = 0.004) on echogenic intensity. Conclusion This pilot study suggests that the use of an echogenic sheath may increase needle visibility, particularly for trajectories requiring steeper insertion angles. To investigate the superiority of the echogenic sheath over conventional needles, a clinical study is necessary.

Bleeding risk and complications associated with percutaneous ultrasound-guided liver biopsy in cats

2018 ◽  
Vol 21 (6) ◽  
pp. 529-536 ◽  
Author(s):  
Michelle Pavlick ◽  
Cynthia RL Webster ◽  
Dominique G Penninck
Keyword(s):  
Liver Biopsy ◽  
Vitamin K ◽  
Major Bleeding ◽  
Bleeding Risk ◽  
Bleeding Complications ◽  
P Value ◽  
Safe Procedure ◽  
Ultrasound Guided ◽  
Coagulation Parameters ◽  
Ultrasound Findings

Objectives Liver biopsy is necessary for a diagnosis of liver disease; however, post-biopsy bleeding is a concern. The aim of this study was to describe the extent of bleeding and the occurrence of complications after percutaneous ultrasound-guided liver biopsy (PUGLB) in cats. Methods The medical records of 30 cats that had a PUGLB were retrospectively reviewed. Using human guidelines, bleeding was classified as minor or major when the absolute change in packed cell volume (ΔPCV) was <0 and >−6% or ≤-6%, respectively. Complications were defined as physiologic compromise necessitating an intervention, or death. The relationship between ΔPCV and the occurrence of complications and the signalment, initial PCV, coagulation parameters, serum liver enzymes and bilirubin, number of biopsies, histological diagnosis, ultrasound findings, radiologist experience, concurrent procedures and vitamin K administration were assessed using Fisher’s exact test, ANOVA and Pearson’s correlation coefficient, with a P value <0.05 considered significant. Results All cats had a decrease in PCV after biopsy. The mean ΔPCV was −6.9% ± 4.1%. Minor and major bleeding occurred in 13/30 (43.3%) and 17/30 (56.7%) cats, respectively, and non-lethal bleeding complications occurred in 5/30 (16.7%). Cats with complications had a lower pre-biopsy PCV ( P <0.003). Major bleeding was more likely with a diagnosis of hepatic lipidosis ( P = 0.03). There was no correlation between ΔPCV or complications and signalment, coagulation parameters, serum parameters, number of biopsies, ultrasound findings, radiologist experience, concurrent procedures and vitamin K administration. Conclusions and relevance PUGLB is a relatively safe procedure in cats, although many cats have a subclinical decrease in PCV. As conventional coagulation tests did not predict complications or the magnitude of ΔPCV, there is a need for more sensitive indicators of bleeding risk in cats undergoing PUGLB.

scholarly journals A case of argininosuccinate synthetase(ASS) deficiency diagnosed by the measurement of ASS with the liver biopsy specimen.

1989 ◽  
Vol 78 (9) ◽  
pp. 1339-1343
Author(s):  
Shigeki MORI ◽  
Yutaka AOYAGI ◽  
Takashi OHNO ◽  
Toshiaki WATANABE ◽  
Minoru NOMOT ◽  
...  
Keyword(s):  
Liver Biopsy ◽  
Biopsy Specimen ◽  
Argininosuccinate Synthetase ◽  
Liver Biopsy Specimen

Do the needle type and the operator experience influence liver biopsy specimen quality?

Open Medicine ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. 669-673
Author(s):  
Ioan Sporea ◽  
Alina Popescu ◽  
Mircea Focşa ◽  
Gabriel Becheanu ◽  
Roxana Şirli ◽  
...  
Keyword(s):  
Liver Biopsy ◽  
Biopsy Specimen ◽  
Liver Biopsy Specimen ◽  
Operator Experience ◽  
Needle Type ◽  
Specimen Quality

Abstract

The Microheterogeneity of Human Liver and Serum Ferritins Measured on Minute Amounts of Ferritin in Crude Samples

1984 ◽  
Vol 21 (6) ◽  
pp. 471-476 ◽  
Author(s):  
F M J Zuyderhoudt ◽  
C Linthorst
Keyword(s):  
Liver Biopsy ◽  
Iron Overload ◽  
Liver Tissue ◽  
Biopsy Specimen ◽  
Unknown Origin ◽  
Enzyme Linked Immunosorbent Assay ◽  
Liver Biopsy Specimen ◽  
Tissue Samples ◽  
Ferritin Concentration ◽  
Biopsy Specimens

A method is presented to measure the microheterogeneity of ferritin in μg amounts, without purifying the samples extensively. Ferritin-containing samples such as serum and homogenized liver-biopsy specimens were mixed with Sephadex G-75 and ampholines. Isoelectric focussing was performed and the pH gradient in the Sephadex was measured. The Sephadex was divided into predetermined pH ranges and the ferritin eluted from these fractions. Ferritin concentration was measured by an enzyme-linked immunosorbent assay. The method proved to be reproducible. The isoferritin profiles of different human serum and liver tissue samples were quite variable. In most cases serum ferritins focussed between approximately pH 5·5 and pH 4·9 and liver ferritins between approximately pH 5·8 and pH 5·3. We examined whether there was a similarity in the isoferritin patterns of serum and liver of distinct patients. We also studied liver tissue and serum from a patient with haemochromatosis and from a child with iron overload of unknown origin. In the serum of our patients the isoferritin pattern had shifted to lower pI when compared with that found in liver tissue. Only in the case of a patient with transfusion iron overload were basic isoferritins measured in the serum. In this case no liver biopsy specimen was available for comparison.

scholarly journals Autoimmune hepatitis: a histological variant associated with prominent centrilobular necrosis

Gut ◽  
1997 ◽  
Vol 41 (2) ◽  
pp. 269-271 ◽  
Author(s):  
H S Te ◽  
G Koukoulis ◽  
D R Ganger
Keyword(s):  
Liver Biopsy ◽  
Autoimmune Hepatitis ◽  
Steroid Therapy ◽  
Biopsy Specimen ◽  
Hepatitis A ◽  
Liver Biopsy Specimen ◽  
Centrilobular Necrosis ◽  
Histological Appearance ◽  
Histological Variant ◽  
Portal Tracts

A patient presented with pruritus and recent elevation of aminotransferases. The case fulfilled most of the criteria for the diagnosis of autoimmune hepatitis and achieved clinical and complete biochemical response to steroid therapy. However, the liver biopsy specimen revealed an unusual histological pattern consisting of severe centrilobular necrosis demarcated by a thin rim of hepatitic reaction. In contrast, the portal tracts appeared almost normal. This histological appearance has not been associated with autoimmune hepatitis. This presentation and the histology may represent an early pattern of autoimmune injury to the liver.

Sign in / Sign up

Export Citation Format

Share Document