scholarly journals Left ventricular atrioventricular plane displacement: an echocardiographic technique for rapid assessment of prognosis in heart failure.

Heart ◽  
1997 ◽  
Vol 78 (3) ◽  
pp. 230-236 ◽  
Author(s):  
R. Willenheimer ◽  
C. Cline ◽  
L. Erhardt ◽  
B. Israelsson
Keyword(s):  
Heart Failure ◽  
Rapid Assessment ◽  
Left Ventricular ◽  
Atrioventricular Plane Displacement ◽  
Plane Displacement ◽  
Echocardiographic Technique

scholarly journals An Intra-Cycle Optimal Control Framework for Ventricular Assist Devices Based on Atrioventricular Plane Displacement Modeling

2021 ◽  
Author(s):  
Clemens Zeile ◽  
Thomas Rauwolf ◽  
Alexander Schmeisser ◽  
Jeremi Kaj Mizerski ◽  
Rüdiger C. Braun-Dullaeus ◽  
...  
Keyword(s):  
Heart Failure ◽  
Blood Flow ◽  
Aortic Valve ◽  
Left Ventricular ◽  
Patient Specific ◽  
Ventricular Assist ◽  
Pump Speed ◽  
Atrioventricular Plane Displacement ◽  
Valve Opening ◽  
Plane Displacement

AbstractA promising treatment for congestive heart failure is the implementation of a left ventricular assist device (LVAD) that works as a mechanical pump. Modern LVADs work with adjustable constant rotor speed and provide therefore continuous blood flow; however, recently undertaken efforts try to mimic pulsatile blood flow by oscillating the pump speed. This work proposes an algorithmic framework to construct and evaluate optimal pump speed policies with respect to generic objectives. We use a model that captures the atrioventricular plane displacement, which is a physiological indicator for heart failure. We employ mathematical optimization to adapt this model to patient specific data and to find optimal pump speed policies with respect to ventricular unloading and aortic valve opening. To this end, we reformulate the cardiovascular dynamics into a switched system and thereby reduce nonlinearities. We consider system switches that stem from varying the constant pump speed and that are state dependent such as valve opening or closing. As a proof of concept study, we personalize the model to a selected patient with respect to ventricular pressure. The model fitting results in a root-mean-square deviation of about 6 mmHg. The optimization that considers aortic valve opening and ventricular unloading results in speed modulation akin to counterpulsation. These in silico findings demonstrate the potential of personalized hemodynamical optimization for the LVAD therapy.

scholarly journals A Personalized Switched Systems Approach for the Optimal Control of Ventricular Assist Devices based on Atrioventricular Plane Displacement

2020 ◽  
Author(s):  
Clemens Zeile ◽  
Thomas Rauwolf ◽  
Alexander Schmeisser ◽  
Jeremi Kaj Mizerski ◽  
Rüdiger C. Braun-Dullaeus ◽  
...  
Keyword(s):  
Heart Failure ◽  
Blood Flow ◽  
Mathematical Optimization ◽  
Left Ventricular ◽  
Rotor Speed ◽  
Ventricular Assist ◽  
Pump Speed ◽  
Atrioventricular Plane Displacement ◽  
Valve Opening ◽  
Plane Displacement

AbstractObjectiveA promising treatment for congestive heart failure is the implementation of a left ventricular assist device (LVAD) that works as a mechanical pump. Modern LVADs work with adjustable constant rotor speed and provide therefore continuous blood flow; however, recently undertaken efforts try to mimic pulsatile blood flow by oscillating the pump speed. This work proposes an algorithmic framework to construct and evaluate optimal pump speed policies.MethodsWe use a model that captures the atrioventricular plane displacement, which is a physiological indicator for heart failure. We employ mathematical optimization to adapt this model to patient specific data and to find optimal pump speed policies with respect to ventricular unloading and aortic valve opening. To this end, we reformulate the cardiovascular dynamics into a switched system and thereby reduce nonlinearities. We consider system switches that stem from varying the constant pump speed and that are state dependent such as valve opening or closing.ResultsAs a proof of concept study, we personalize the model to a selected patient with respect to ventricular pressure. The model fitting results in a root-mean-square deviation of about 6 mmHg. Optimized constant and piecewise constant rotor speed profiles improve the default initialized solution by 31% and 68% respectively.ConclusionThese in silico findings demon-strate the potential of personalized hemodynamical optimization for the LVAD therapy.SignificanceLVADs and their optimal configuration are active research fields. Mathematical optimization enhances our understanding of how LVADs should provide pulsatility.

Atrioventricular plane displacement in the patients with congestive heart failure

1993 ◽  
Vol 1 (2) ◽  
pp. 152
Author(s):  
Ji Won Son ◽  
Dong Ho Kam ◽  
Sang Moon Bae ◽  
Sang Gon Kim ◽  
Moon Beom Kim ◽  
...  
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Atrioventricular Plane Displacement ◽  
Plane Displacement

scholarly journals Ventricular longitudinal shortening is an independent predictor of death in heart failure patients with reduced ejection fraction

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
J. Berg ◽  
R. Jablonowski ◽  
M. Mohammad ◽  
K. Solem ◽  
R. Borgquist ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Univariate Analysis ◽  
Global Longitudinal Strain ◽  
National Registry ◽  
Reduced Ejection Fraction ◽  
Kaplan Meier ◽  
Incremental Value ◽  
Atrioventricular Plane Displacement ◽  
Plane Displacement

AbstractReduced ventricular longitudinal shortening measured by atrioventricular plane displacement (AVPD) and global longitudinal strain (GLS) are prognostic markers in heart disease. This study aims to determine if AVPD and GLS with cardiovascular magnetic resonance (CMR) are independent predictors of cardiovascular (CV) and all-cause death also in heart failure with reduced ejection fraction (HFrEF). Patients (n = 287) were examined with CMR and AVPD, GLS, ventricular volumes, myocardial fibrosis/scar were measured. Follow-up was 5 years with cause of death retrieved from a national registry. Forty CV and 60 all-cause deaths occurred and CV non-survivors had a lower AVPD (6.4 ± 2.0 vs 8.0 ± 2.4 mm, p < 0.001) and worse GLS (− 6.1 ± 2.2 vs − 7.7 ± 3.1%, p = 0.001). Kaplan–Meier analyses displayed increased survival for patients in the highest AVPD- and GLS-tertiles vs. the lowest tertiles (AVPD: p = 0.001, GLS: p = 0.013). AVPD and GLS showed in univariate analysis a hazard ratio (HR) of 1.30 (per-mm-decrease) and 1.19 (per-%-decrease) for CV death. Mean AVPD and GLS were independent predictors of all-cause death (HR = 1.24 per-mm-decrease and 1.15 per-%-decrease), but only AVPD showed incremental value over age, sex, body-mass-index, EF, etiology and fibrosis/scar for CV death (HR = 1.33 per-mm-decrease, p < 0.001). Ventricular longitudinal shortening remains independently prognostic for death in HFrEF even after adjusting for well-known clinical risk factors.

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