CpG ISLAND METHYLATION PATTERNS IN VARIOUS HISTOTYPES OF ENDOMETRIAL CANCER: 0011

2005 ◽  
Vol 15 (2) ◽  
pp. 405.1-405
Author(s):  
R. R. Broaddus ◽  
S.-S. Xie ◽  
L. Ramondetta ◽  
J.-P. Issa ◽  
D. Loose
Keyword(s):  
Endometrial Cancer ◽  
Cpg Island ◽  
Cpg Island Methylation ◽  
Methylation Patterns

CpG Island methylation patterns in various histotypes of endometrial cancer

2005 ◽  
Vol 15 (2) ◽  
pp. 405-405
Author(s):  
R.R. Broaddus ◽  
S.-S. Xie ◽  
L. Ramondetta ◽  
J.-P. Issa ◽  
D. Loose
Keyword(s):  
Endometrial Cancer ◽  
Cpg Island ◽  
Cpg Island Methylation ◽  
Methylation Patterns

scholarly journals Epigenetic Functions of Smchd1 Repress Gene Clusters on the Inactive X Chromosome and on Autosomes

2013 ◽  
Vol 33 (16) ◽  
pp. 3150-3165 ◽  
Author(s):  
Anne-Valerie Gendrel ◽  
Y. Amy Tang ◽  
Masako Suzuki ◽  
Jonathan Godwin ◽  
Tatyana B. Nesterova ◽  
...  
Keyword(s):  
X Chromosome ◽  
Cpg Island ◽  
Regulation Of Gene Expression ◽  
Gene Clusters ◽  
Developmentally Regulated ◽  
Inactive X Chromosome ◽  
Genome Wide ◽  
Cpg Island Methylation ◽  
Methylation Patterns ◽  
Genome Wide Expression

TheSmchd1gene encodes a large protein with homology to the SMC family of proteins involved in chromosome condensation and cohesion. Previous studies have found that Smchd1 has an important role in CpG island (CGI) methylation on the inactive X chromosome (Xi) and in stable silencing of some Xi genes. In this study, using genome-wide expression analysis, we showed that Smchd1 is required for the silencing of around 10% of the genes on Xi, apparently independent of CGI hypomethylation, and, moreover, that these genes nonrandomly occur in clusters. Additionally, we found that Smchd1 is required for CpG island methylation and silencing at a cluster of four imprinted genes in the Prader-Willi syndrome (PWS) locus on chromosome 7 and genes from the protocadherin-alpha and -beta clusters. All of the affected autosomal loci display developmentally regulated brain-specific methylation patterns which are lost inSmchd1homozygous mutants. We discuss the implications of these findings for understanding the function of Smchd1 in epigenetic regulation of gene expression.

CpG island methylation patterns in chronic lymphocytic leukemia

2009 ◽  
Vol 50 (3) ◽  
pp. 419-426 ◽  
Author(s):  
Barbara Seeliger ◽  
Stefan Wilop ◽  
Rainhardt Osieka ◽  
Oliver Galm ◽  
Edgar Jost
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Cpg Island ◽  
Lymphocytic Leukemia ◽  
Cpg Island Methylation ◽  
Methylation Patterns

CpG Island Methylation Patterns in Relapsing-Remitting Multiple Sclerosis

2018 ◽  
Vol 64 (3) ◽  
pp. 478-484 ◽  
Author(s):  
Maria Sokratous ◽  
Efthimios Dardiotis ◽  
Eleni Bellou ◽  
Zisis Tsouris ◽  
Amalia Michalopoulou ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cpg Island ◽  
Relapsing Remitting ◽  
Cpg Island Methylation ◽  
Remitting Multiple Sclerosis ◽  
Methylation Patterns ◽  
Relapsing Remitting Multiple Sclerosis
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