EP953 Poor AT and VO2 max recorded during cardiopulmonary exercise testing (CPET) prior to cytoreductive surgery in advanced (Stage 3/4) ovarian cancer (AOC) is associated with suboptimal cytoreduction but does preclude maximum effort cytoreduction

Author(s):  
K Element ◽  
P Mehrotra ◽  
V Asher ◽  
A Bali ◽  
S Abdul ◽  
...  
2017 ◽  
Vol 1 (2) ◽  
pp. 33
Author(s):  
Arfi Fachrul Imaduddin ◽  
Yuni Susanti Pratiwi ◽  
Sunaryo B. Sastradimaja

VO2 max can be measured with two protocols, namely direct and indirect. Direct protocolsare known to be valid, but more difficult and expensive. The indirect protocol is often asked ofits validity, but it is practical and cheapest to use in the field. One of the indirect protocolsthat can be used in children is 20-meter Multi-Stage Running (20-MST). This study aimed todetermine the correlation between the 20-MST with Cardiopulmonary Exercise Testing(CPET) in boys. This research used descriptive analytic study design. The subjects were 38boys aged from 11 to 12 of extracurricular sports club members. The research variables areVO2 max results with 2 methods of measurement which are 20-MST and CPET. The statisticaldata were analyzed with Pearson correlation. The result of VO2 max (ml.kg-1.min-1)measurement by the method of 20-MST (28.6 7.962) and result by the method of CPET(40.683 10.7 31) and the correlation value between 20-MST and CPET with R=0.674. Weconcluded that there is a strong correlation between 20-MST test and CPET test for predictingVO2 max among boys.


2021 ◽  
Vol 2 (1) ◽  
pp. 20
Author(s):  
Arfi Fachrul Imaduddin ◽  
Yuni Susanti Pratiwi ◽  
Sunaryo B. Sastradimaja

VO2 max can be measured with two protocols, namely direct and indirect. Direct protocols are known to be valid, but more difficult and expensive. The indirect protocol is often asked of its validity, but it is practical and cheapest to use in the field. One of the indirect protocols that can be used in children is 20-meter Multi-Stage Running (20-MST). This study aimed to determine the correlation between the 20-MST with Cardiopulmonary Exercise Testing (CPET) in boys. This research used descriptive analytic study design. The subjects were 38 boys aged from 11 to 12 of extracurricular sports club members. The research variables are VO2 max results with 2 methods of measurement which are 20-MST and CPET. The statistical data were analyzed with Pearson correlation. The result of VO2 max (ml.kg-1-1.min) measurement by the method of 20-MST (28.6 ± 7.962) and result by the method of CPET (40.683 ± 10.7 31) and the correlation value between 20-MST and CPET with R=0.674. We concluded that there is a strong correlation between 20-MST test and CPET test for predicting VO2 max among boys.


2019 ◽  
Vol 19 (6) ◽  
pp. 449-467
Author(s):  
Zhiquan Liang ◽  
Ziwen Lu ◽  
Yafei Zhang ◽  
Dongsheng Shang ◽  
Ruyan Li ◽  
...  

Ovarian cancer is a leading cause of death worldwide from gynecological malignancies, mainly because there are few early symptoms and the disease is generally diagnosed at an advanced stage. In addition, despite the effectiveness of cytoreductive surgery for ovarian cancer and the high response rates to chemotherapy, survival has improved little over the last 20 years. The management of patients with ovarian cancer also remains similar despite studies showing striking differences and heterogeneity among different subtypes. It is therefore clear that novel targeted therapeutics are urgently needed to improve clinical outcomes for ovarian cancer. To that end, several membrane receptors associated with pivotal cellular processes and often aberrantly overexpressed in ovarian cancer cells have emerged as potential targets for receptor-mediated therapeutic strategies including specific agents and multifunctional delivery systems based on ligand-receptor binding. This review focuses on the profiles and potentials of such strategies proposed for ovarian cancer treatment and imaging.


Diagnostics ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 364
Author(s):  
Keisuke Miki

In chronic obstructive pulmonary disease (COPD), exertional dyspnea, which increases with the disease’s progression, reduces exercise tolerance and limits physical activity, leading to a worsening prognosis. It is necessary to understand the diverse mechanisms of dyspnea and take appropriate measures to reduce exertional dyspnea, as COPD is a systemic disease with various comorbidities. A treatment focusing on the motor pathophysiology related to dyspnea may lead to improvements such as reducing dynamic lung hyperinflation, respiratory and metabolic acidosis, and eventually exertional dyspnea. However, without cardiopulmonary exercise testing (CPET), it may be difficult to understand the pathophysiological conditions during exercise. CPET facilitates understanding of the gas exchange and transport associated with respiration-circulation and even crosstalk with muscles, which is sometimes challenging, and provides information on COPD treatment strategies. For respiratory medicine department staff, CPET can play a significant role when treating patients with diseases that cause exertional dyspnea. This article outlines the advantages of using CPET to evaluate exertional dyspnea in patients with COPD.


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