scholarly journals 1158 Prevalence of endometrial carcinoma in women with myoma uteri associated abnormal uterine bleeding (AUB) in a tertiary government hospital

2021 ◽  
Author(s):  
JL Tanchuling
Keyword(s):  
Endometrial Carcinoma ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
Government Hospital ◽  
Myoma Uteri

scholarly journals Histo-Pathological Study of Endometrial Biopsies in Patients With Abnormal Uterine Bleeding

2017 ◽  
Vol 15 (2) ◽  
pp. 26-31
Author(s):  
Sharmila Parajuli ◽  
Binita Thapa
Keyword(s):  
Endometrial Carcinoma ◽  
Postmenopausal Women ◽  
Abnormal Uterine Bleeding ◽  
The Elderly ◽  
Endometrial Biopsy ◽  
Uterine Bleeding ◽  
Common Cause ◽  
Histopathological Findings ◽  
Common Sign ◽  
Work Up

Introduction: Abnormal uterine bleeding is a common sign of a number of different uterine disorders ranging from dysfunctional (non organic) abnormalities or complications of pregnancy to organic lesions such as polyps, hyperplasia or carcinoma. Methods: This is a retrospective study conducted at Hospital of 2nd author during a period of 5 years (Jan 2008-Dec 2013).  Histopathology records were retrieved and searched for cases of abnormal uterine bleeding. Relevant histopathological findings and clinical data were recorded and analyzed. The aim of the study was to determine the causes for abnormal uterine bleeding in women presenting to the hospital and to compare the histopathological findings at various age groups.Results: The age of patients ranged from 17 to 71 years with an average of 43 years. The most common cause of uterine bleeding was found to be proliferative phase endometrium; that were 649 cases (56.43%). Out of the pathological causes, the most common cause was found to be endometrial hyperplasia- 44 cases (3.82%). Endometrial carcinoma was found to be more common in the elderly postmenopausal women. A total of 6 cases (0.5%) of endometrial carcinoma were present.Conclusion: Endometrial hyperplasias and malignancies are common in increasing age group, especially in perimenopausal and postmenopausal women. So, a thorough work-up and diagnostic endometrial biopsy is therefore mandatory without delay in these patients to rule out malignancies. 

scholarly journals Prevalence and characteristics of endometrial polyps in patients with abnormal uterine bleeding

2008 ◽  
Vol 65 (5) ◽  
pp. 349-352 ◽  
Author(s):  
Biljana Djordjevic ◽  
Jelena Milosevic ◽  
Zorica Stanojevic
Keyword(s):  
Endometrial Carcinoma ◽  
Statistical Significance ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
Atypical Hyperplasia ◽  
Endometrial Polyps ◽  
Female Population ◽  
Group A ◽  
Malignant Changes ◽  
Group B

Background/Aim. The prevalence of endometrial polyps (EPs) in the general female population is about 24%. Abnormal uterine bleeding is frequently the presenting symptom of EPs. The aim of this study was to determine the prevalence and characteristics of EPs in patients with abnormal uterine bleeding. Methods. The prevalence and characteristics of EPs were investigated in 961 patients with abnormal uterine bleeding who underwent dilatation and curettage between January and December 2006. Regarding histopathological features of EPs (presence of atypical hyperplasia or endometrial carcinoma), patients were divided into two groups: group A - patients who had EPs and EPs with hyperplasia without atypia (n = 204) and group B - patients who had EPs with atypical hyperplasia and EPs with carcinoma (n = 7). Results. In 211 (21.94%) patients EPs were found with abnormal uterine bleeding. Histopathologically, there were 175 (82.94%) EPs, 29 (13.74%) EPs with hyperplasia without atypia, 5 (2.37%) EPs with atypical hyperplasia, and 2 (0.95%) EPs with endometrial carcinoma. Contrary to the patients with EPs and EPs with hyperplasia without atypia (group A), patients who had EPs with atypical hyperplasia and EPs with carcinoma (group B) were older (p < 0.05), and more commonly postmenopausal (p < 0.05) and with hypertension (p < 0.05), all of statistical significance. Conclusion. The prevalence of endometrial polyps in patients with abnormal uterine bleeding according to our data was 21.95%. Atypical hyperplasia and endometrial carcinoma were rarely confined to a polyp. Older age, postmenopausal period and hypertension may increase the risk of premalignant and malignant changes in endometrial polyps.

scholarly journals To compare trans-vaginal ultrasound colour doppler (TUCD) with hysteroscopy and guided endometrial biopsy in diagnosing abnormal uterine bleeding

2017 ◽  
Vol 6 (7) ◽  
pp. 3035
Author(s):  
Swati Choudhary ◽  
Syed Nawaz Ahmad ◽  
Shefali Agarwal
Keyword(s):  
Endometrial Carcinoma ◽  
Abnormal Uterine Bleeding ◽  
Diagnostic Procedures ◽  
Endometrial Biopsy ◽  
Uterine Bleeding ◽  
Kappa Statistics ◽  
Colour Doppler ◽  
Endometrial Polyps ◽  
Vaginal Ultrasound ◽  
Postmenopausal Female

Background: To compare trans-vaginal ultrasound Colour Doppler (TUCD) with hysteroscopy and guided endometrial biopsy in diagnosing abnormal uterine bleeding.Methods: A total of 50 consecutive and haemodynamically stable patients aged more than 40 years with abnormal uterine bleeding (AUB) were included in the study. Patients with pregnancy and probable cervical malignancy were excluded. All the patients were subjected to TUCD followed by hysteroscopic directed endometrial biopsy during the follicular phase of the menstrual cycle between 7th and 11th day to diagnose the underlying pathology. In postmenopausal female both TUCD and hysteroscopy were performed on any day. Results of both the procedures were compared.Results: The sensitivity and specificity of TUCD as compared to hysteroscopy in diagnosing polyp was found out to be 27.78% and 100%; for fibroid 100% and 84.4%; for endometrial hyperplasia 86.36% and 96.43%; for endometrial carcinoma 71.43% and 100%; and for endometrial atrophy 100% and 100%, respectively. After application of kappa statistics, the degree of agreement between the two diagnostic procedures was found to be 0.599 which was considered to be good.Conclusions: Conditions like fibroid, endometrial atrophy and cases of A-V malformation are better diagnosed with TUCD, while others like endometrial polyps, endometrial carcinoma are better detected on hysteroscopy. TUCD can diagnose most of the pathologies but not all, so it can be used as an adjunct to hysteroscopy to diagnose endometrial pathology, but can surely not replace hysteroscopy.

Myoma Uteri and Abnormal Uterine Bleeding

1972 ◽  
Vol 65 (11) ◽  
pp. 1356-1359
Author(s):  
S DUCKMAN ◽  
L SESE ◽  
J SUAREZ ◽  
P TANTAKESEM
Keyword(s):  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
Myoma Uteri

scholarly journals Relationship of Retinol Binding Protein Four Serum Level on Endometrial Hyperplasia and Endometrial Carcinoma

2018 ◽  
pp. 243-247
Author(s):  
Ivan Limy ◽  
Eddy Suparman ◽  
Hermie M. M. Tendean
Keyword(s):  
Endometrial Carcinoma ◽  
Endometrial Hyperplasia ◽  
Binding Protein ◽  
Elevated Serum ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
Retinol Binding Protein ◽  
Serum Retinol ◽  
Retinol Binding Protein 4 ◽  
Carcinoma Endometrium

Abstract Objective : To determine the relationship of elevated serum retinol binding protein 4 with abnormal uterine bleeding Methods : This study was an observational quantitative with cross sectional methods, with all women who had abnormal uterine bleeding caused either by endometrial carcinoma or endometrial hyperplasia at RSUP Prof.DR.RD Kandou, and affiliation hospitals from November 2016 until April 2017. Data were analyzed With SPSS version 2.0 to see the significancy level. Results: Of 26 research subjects, 23 subjects with endomtrial hyperplasia and 3 subjects with endometrial carcinoma. From the total of 26 malignancy and hyperplasia diagnoses, 21 had IMT> 25 and 23 were diagnosed with Endometrial Hyperplasia and 3 Carcinoma Endometrium. 18 subjects had elevated serum RBP4 levels, with 15 people with endometrial hyperplasia and 3 with endometrial carcinoma. With the Fischer Exact test statistic, serum retinol binding protein 4 levels were found in both endometrial hyperplasia and endometrial carcinoma p = 1.00, meaning no significant difference for the occurrence of abnormal uterine bleeding. Conclusion: There was no significant association between serum retinol binding protein 4 between endomterium carcinoma and endometrial hyperplasia. Keywords: abnormal uterine bleeding, endometrial carcinoma, endometrial hyperplasia, serum retinol binding protein 4   Abstrak Tujuan : Mengetahui adanya hubungan peningkatan kadar serum retinol binding protein 4 pada hyperplasia endomterium dengan carcinoma endometrium Metode : Penelitian ini adalah jenis kuantitatif observasional secara potong lintang, dengan semua perempuan yang mengalami perdarahan uterus abnormal yang disebabkan oleh hiperplasia endometrium atau carcinoma endometrium di Bagian Kebidanan dan Kandungan Rumah Sakit Umum Pusat (RSUP) Prof.DR.R.D Kandou, dan RS jejaring mulai November 2016 sampai April 2017.Data dianalisa dengan SPSS versi 2.0 untuk melihat tingkat kemaknaannya. Hasil : Dari 26 subjek penelitian, 23 subjek dengan hyperplasia endomtrium dan 3 subjek dengan carcinoma endometrium. Didapatkan data penelitian dari total keganasan diagnosa  dan hiperplasia sejumlah 26 orang, sebanyak 21 orang memiliki IM T>25 dan sebanyak 23 orang didiagnosa dengan Hiperplasia Endometrium dan 3 orang karsinoma Endometrium. Didapatkan sebanyak 18 subyek penelitian mengalami peningkatan kadar serum RBP 4, dengan 15 orang yang mengalami hiperplasia endometrium dan 3 orang dengan karsinoma endometrium. Dengan uji statistik Fischer Exact test, didapatkan kadar serum retinol binding protein 4 baik pada hiperplasia endometrium dengan karsinoma endometrium p=1.00, mengartikan tidak mempunyai perbedaan bermakna untuk terjadinya perdarahan uterus abnormal. Kesimpulan : Tidak terdapat hubungan bermakna kadar serum retinol binding protein 4 antara karsinoma endomterium dengan hiperplasia endometrium. Kata kunci : hiperplasia endometrium , kadar serum retinol binding protein 4, karsinoma endometrium, perdarahan uterus abnormal

scholarly journals Frequency of Common Histopathological Findings among Patients Having Endometrial Thickness ≥5mm

2021 ◽  
Vol 15 (9) ◽  
pp. 2236-2238
Author(s):  
Sadia Sharif ◽  
Ayesha Sajjad ◽  
Amna Kazi ◽  
Ayesha Masood ◽  
Nazish Javaid
Keyword(s):  
Body Mass Index ◽  
Endometrial Carcinoma ◽  
Body Mass ◽  
Rural Areas ◽  
Endometrial Thickness ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
Transvaginal Ultrasonography ◽  
Cross Sectional ◽  
Histopathological Findings

Aim: To determine the frequency of common histopathological findings among patients having endometrial thickness >5mm and having atypical bleeding of uterus. Study design: Descriptive and cross sectional study Study settings: Department of Obstetrics & Gynaecology, Kishwer Fazal Teaching Hospital, Sheikhupura from 1st October 2020 to 31st March 2021. Methodology: One hundred and twenty patients were enrolled. Patients were aged between 45 to 60 years. Patient’s detailed demographics including age, parity, socioeconomic grade and body mass index were recorded post written informed consentreceival. Patients having endometrial thickness >5mm with abnormal uterine bleeding were included in this study.All the patients were undergone for transvaginal ultrasonography (TVS). Outcomes were histopathological findings observed. Results: The patients mean age was found to be 51.16±4.88 years with mean body mass index 27.24±4.63 kg/m2. Thirty five (29.2%) patients had parity I and 85 (70.8%) patients had parity II. Forty two (35%) patients had high socioeconomic status and 78(65%) were from low socio economic status. Majority of the patients 80(66.7%) were from rural areas. Secretory and proliferative were the most common histopathological findings found in (45.83% and 26.7%) patients. Frequency of endometrial carcinoma was found among 97(80.8%) cases. Conclusion: The most common histopathological findings were secretory and proliferative and frequency of endometrial carcinoma was too high. Endometrial anomalies can be excluded by transvaginal ultrasonography and is strongly useful in the evaluation of abnormal bleeding from the uterine. Keywords: Endometrial, Transvaginal ultrasonography, Uterine bleeding

Morphological pattern of endometrial pathology during postmenopause

2021 ◽  
Vol 20 (5) ◽  
pp. 51-57
Author(s):  
N.V. Ivanova ◽  
◽  
M.V. Shamarakova ◽  
O.B. Panina ◽  
M.R. Gribova ◽  
...  
Keyword(s):  
Endometrial Carcinoma ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
Morphological Pattern ◽  
Functional Changes ◽  
Group 4 ◽  
Group 3 ◽  
Group 2 ◽  
Endometrial Pathology ◽  
Group 1

Objective. To study the morphological pattern of endometrial pathology in the menopausal women considering clinical symptoms and duration of the menopausal period. Patients and methods. 1032 women in the postmenopause were observed. Clinical data, the results of ultrasound and pathomorphological examination were studied. All patients were divided into the following groups: group 1 consisted of patients with menopausal duration for 1–5 years; group 2 – for 6–10 years; group 3 – for 10–20 years; group 4 – for more than 20 years. Results. Abnormal uterine bleeding (AUB) was registered in 39% of patients from group 1, in 13% of patients both from group 2 and group 3, and in 7% of patients from group 4. Endometrial thickening according to the ultrasound results was observed in 39% of patients from group 1, in 58% of patients from group 2, in 53% of patients both from group 3 and group 4. The combination of AUB and increased endometrial thickness was found in 27% of patients from group 1, in 29% from group 2, in 34% from group 3, and in 40% from group 4. Functional changes in the endometrium represented by the regenerating endometrium, proliferative endometrium, and endometrial hyperplasia were found in 31% of patients from group 1 and in 4% of patients from group 2. The incidence of endometrial carcinoma increased with the increasing duration of the menopause and was 7% in group 1, 12% in group 2, 24% in group 3, and 30% in group 4. Conclusion. The leading cause of AUB in women during the first 5 years of the menopause is functional change in the endometrium. Patients with menopausal duration of more than 10 years and the presence of AUB constitute a risk group of developing endometrial carcinoma. Key words: abnormal uterine bleeding, menopause, endometrial carcinoma

scholarly journals Transvaginal ultrasonography is the diagnostic method for evaluation of abnormal uterine bleeding

2012 ◽  
Vol 1 (1) ◽  
pp. 11-13
Author(s):  
Kulsum Haq ◽  
Shabnom Ferdous Chowdhury ◽  
Maksuda Mannan ◽  
Rokshana Ivy ◽  
K Shahneela Tasnim
Keyword(s):  
Endometrial Carcinoma ◽  
Predictive Value ◽  
Endometrial Hyperplasia ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
Endometrial Polyp ◽  
Transvaginal Ultrasonography ◽  
Transvaginal Sonography ◽  
Dysfunctional Uterine Bleeding ◽  
Histopathologic Evaluation

Objective: The objective of this study is to assess the utility of transvaginal ultrasonography in patients presenting abnormal uterine bleeding Materials and methods: Between July 2000 to December 2000, 50 patients underwent transvaginal sonography (TVS) for abnormal uterine bleeding. All patients had transvaginal sonography before histopathology. On TVS, the sonographic appearance of the endometrium was classified according to the following parameters: normal or abnormal thickness, homogeneous or heterogeneous echogenicity, bulbous contour, discontinuous, or obscured. A comparison was performed between TVS with histopathology. Results: The most common causes for the abnormal uterine bleeding were leiomyoma in TVS (42.0%). Other causes were dysfunctional uterine bleeding (28.0%). adenomyosis (6.0%), endometrial polyp (4.0%), thin atrophic endometrium (8.0%), endometrial hyperplasia (8.0%), and endometrial carcinoma (4.0%). After histopathologic evaluation 40.0% patients had leiomyoma, 24.0% DUB, 10.0% adenomyosis, 8.0% endometrial polyp, 8.0% thin atrophic endometrium, 6.0% endometrial carcinoma and 4.0% endometrial hyperplasia. Comparing the TVS with histopathologic findings, TVS had a sensitivity of 94.3%, specificity of 80.0%. accuracy of 90.0%, PPV of 91.6% and NPV of 85.7%. Conclusion: TVS is an easy, safe, rapid and tolerable procedure. It has an excellent diagnostic accuracy in the diagnosis of uterine pathology responsible for abnormal uterine bleeding. Abbreviation: TVS transvaginal sonography; AUB abnormal uterine bleeding; DUB dysfunctional uterine bleeding, PPV positive predictive value, NPV Negative predictive value. DOI: http://dx.doi.org/10.3329/jssmc.v1i1.12168 Journal of Shaheed Suhrawardy Medical College Vol.1, No.1, December 2009 p.11-13

scholarly journals Adiponectin levels in patients with endometrial carcinoma and abnormal uterine bleeding

2019 ◽  
Vol 6 (4) ◽  
pp. 509-513
Author(s):  
Nithin Kumar U ◽  
◽  
M G Sridhar ◽  
K Srilatha ◽  
Syed Habeebullah ◽  
...  
Keyword(s):  
Endometrial Carcinoma ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding
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