scholarly journals P47 Are obesity and inflammation from midlife associated with physical fatigability in old age? findings from a british birth cohort study

Author(s):  
R Cooper ◽  
M Popham ◽  
AJ Santanasto ◽  
NW Glynn ◽  
D Kuh
BMJ Open ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. e025755 ◽  
Author(s):  
Diana Kuh ◽  
Rebecca Hardy ◽  
Joanna M Blodgett ◽  
Rachel Cooper

ObjectivesTo test whether developmental factors are associated with grip strength trajectories between 53 and 69 years, and operate independently or on the same pathway/s as adult factors.DesignBritish birth cohort study.SettingEngland, Scotland and Wales.Participants3058 men and women.Main outcome measuresGrip strength (kg) at ages 53, 60–64 and 69 were analysed using multilevel models to estimate associations with developmental factors (birth weight, growth parameters, motor and cognitive development) and father’s social class, and investigate adult factors that could explain observed associations, testing for age and sex interactions.ResultsIn men, heavier birth weight, beginning to walk ‘on time’, later puberty and greater weight 0–26 years and in women, heavier birth weight and earlier age at first standing were independently associated with stronger grip but not with its decline. The slower decline in grip strength (by 0.07 kg/year, 95% CI 0.02 to 0.11 per 1 SD, p=0.003) in men of higher cognitive ability was attenuated by adjusting for adult verbal memory.ConclusionsPatterns of growth and motor development have persisting associations with grip strength between midlife and old age. The strengthening associations with cognition suggest that, at older ages, grip strength increasingly reflects neural ageing processes. Interventions across life that promote muscle development or maintain muscle strength should increase the chance of an independent old age.


2018 ◽  
Vol 31 (5) ◽  
pp. 717-721 ◽  
Author(s):  
M. J. Haapanen ◽  
M. M. Perälä ◽  
C. Osmond ◽  
M. K. Salonen ◽  
E. Kajantie ◽  
...  

2014 ◽  
Vol 68 (6) ◽  
pp. 516-523 ◽  
Author(s):  
David Bann ◽  
Rachel Cooper ◽  
Andrew K Wills ◽  
Judith Adams ◽  
Diana Kuh ◽  
...  

2015 ◽  
Vol 69 (Suppl 1) ◽  
pp. A63.1-A63
Author(s):  
D Kuh ◽  
R Cooper ◽  
J Adams ◽  
A Moore ◽  
K MacKinnon ◽  
...  

2017 ◽  
Vol 28 (9) ◽  
pp. 2717-2722 ◽  
Author(s):  
T. M. Mikkola ◽  
M. B. von Bonsdorff ◽  
C. Osmond ◽  
M. K. Salonen ◽  
E. Kajantie ◽  
...  

2016 ◽  
Vol 115 (5) ◽  
pp. 878-886 ◽  
Author(s):  
Mia-Maria Perälä ◽  
Mikaela von Bonsdorff ◽  
Satu Männistö ◽  
Minna K. Salonen ◽  
Mika Simonen ◽  
...  

AbstractEpidemiological studies have shown that a number of nutrients are associated with better physical performance. However, little is still known about the role of the whole diet, particularly a healthy Nordic diet, in relation to physical performance. Therefore, we examined whether a healthy Nordic diet was associated with measures of physical performance 10 years later. We studied 1072 participants from the Helsinki Birth Cohort Study. Participants’ diet was assessed using a validated 128-item FFQ at the mean age of 61 years, and a priori-defined Nordic diet score (NDS) was calculated. The score included Nordic fruits and berries, vegetables, cereals, PUFA:SFA and trans-fatty acids ratio, low-fat milk, fish, red and processed meat, total fat and alcohol. At the mean age of 71 years, participants’ physical performance was measured using the Senior Fitness Test (SFT), and an overall SFT score was calculated. Women in the highest fourth of the NDS had on average 5 points higher SFT score compared with those in the lowest fourth (Pfor trend 0·005). No such association was observed in men. Women with the highest score had 17 % better result in the 6-min walk test, 16 % better arm curl and 20 % better chair stand results compared with those with the lowest score (all P values<0·01). In conclusion, a healthy Nordic diet was associated with better overall physical performance among women and might help decrease the risk of disability in old age.


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