scholarly journals O-003 Adequate lateral compression is a strong independent predictor of aneurysm occlusion and retreatment after endovascular treatment with WEB

2021 ◽  
Author(s):  
J Delgado Almandoz ◽  
Y Kayan ◽  
A Copelan ◽  
J Scholz
Keyword(s):  
Endovascular Treatment ◽  
Independent Predictor ◽  
Lateral Compression ◽  
Aneurysm Occlusion ◽  
Strong Independent Predictor

scholarly journals The extreme capsule and aphasia: proof-of-concept of a new way relating structure to neurological symptoms

2021 ◽  
Vol 3 (2) ◽  
Author(s):  
Ariane Martinez Oeckel ◽  
Michel Rijntjes ◽  
Volkmar Glauche ◽  
Dorothee Kümmerer ◽  
Christoph P Kaller ◽  
...  
Keyword(s):  
Independent Predictor ◽  
Study Cohort ◽  
Proof Of Concept ◽  
Stroke Patients ◽  
Functional Regions ◽  
Lesion Mapping ◽  
Ventral Pathway ◽  
Token Test ◽  
Strong Independent Predictor ◽  
Language Network

Abstract We present anatomy-based symptom-lesion mapping to assess the association between lesions of tracts in the extreme capsule and aphasia. The study cohort consisted of 123 patients with acute left-hemispheric stroke without a lesion of language-related cortical areas of the Stanford atlas of functional regions of interest. On templates generated through global fibre tractography, lesions of the extreme capsule and of the arcuate fascicle were quantified and correlated with the occurrence of aphasia (n = 18) as defined by the Token Test. More than 15% damage of the slice plane through the extreme capsule was a strong independent predictor of aphasia in stroke patients, odds ratio 16.37, 95% confidence interval: 3.11–86.16, P < 0.01. In contrast, stroke lesions of >15% in the arcuate fascicle were not associated with aphasia. Our results support the relevance of a ventral pathway in the language network running through the extreme capsule.

scholarly journals Endovascular treatment of intracranial ‘blister’ and dissecting aneurysms

2019 ◽  
Vol 32 (5) ◽  
pp. 353-365 ◽  
Author(s):  
Marius G Kaschner ◽  
Bastian Kraus ◽  
Athanasios Petridis ◽  
Bernd Turowski
Keyword(s):  
Endovascular Treatment ◽  
Favourable Outcome ◽  
Modified Rankin Scale ◽  
Parent Vessel ◽  
Vessel Occlusion ◽  
Parent Vessel Occlusion ◽  
Aneurysm Occlusion ◽  
Vessel Reconstruction ◽  
Dissecting Aneurysms

IntroductionBlister and dissecting aneurysms may have a different pathological background but they are commonly defined by instability of the vessel wall and bear a high risk of fatal rupture and rerupture. Lack of aneurysm sack makes treatment challenging.PurposeThe purpose of this study was to assess the safety and feasibility of endovascular treatment of intracranial blister and dissecting aneurysms.MethodsWe retrospectively analysed all patients with ruptured and unruptured blister and dissecting aneurysms treated endovascularly between 2004–2018. Procedural details, complications, morbidity/mortality, clinical favourable outcome (modified Rankin Scale ≤2) and aneurysm occlusion rates were assessed.ResultsThirty-four patients with endovascular treatment of 35 aneurysms (26 dissecting aneurysms and 9 blister aneurysms) were included. Five aneurysms were treated by parent vessel occlusion, and 30 aneurysms were treated by vessel reconstruction using stent monotherapy ( n = 9), stent-assisted coiling ( n = 7), flow diverting stents ( n = 13) and coiling + Onyx embolization ( n = 1). No aneurysm rebleeding and no procedure-related major complications or deaths occurred. There were five deaths in consequence of initial subarachnoid haemorrhage. Complete occlusion (79.2%) was detected in 19/24 aneurysms available for angiographic follow-up, and aneurysm recurrence in 2/24 (8.3%). The modified Rankin Scale ≤2 rate at mean follow-up of 15.1 months was 64.7%.ConclusionTreatment of blister and dissecting aneurysms developed from coil embolization to flow diversion with multiple stents to the usage of flow diverting stents. Results using modern flow diverting stents encourage us to effectively treat this aneurysm entity endovascularly by vessel reconstruction. Therefore, we recommend preference of vessel reconstructive techniques to parent vessel occlusion.

Post Thaw Colony Forming Units (CFU) Is a Strong Independent Predictor of Engraftment after Unrelated Donor Umbilical Cord Blood Transplantation (UCBT).

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 3282-3282
Author(s):  
Kristin M. Page ◽  
Adam Mendizabal ◽  
Barbara Waters-Pick ◽  
Sophia Avrutsky ◽  
Melissa Reese ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Independent Predictor ◽  
Multivariate Model ◽  
P Value ◽  
Unrelated Donor ◽  
Strong Independent Predictor ◽  
Neutrophil Engraftment

Abstract Background: Unrelated donor umbilical cord blood is an acceptable graft source for patients lacking related donors. However, a non-engraftment rate of approximately 20% despite adequate total nucleated cell (TNC) dose remains a barrier to the overall success of UCBT. Of various patient and graft characteristics that may influence engraftment, identifying an assay predictive of cord blood unit (CBU) potency and overall engraftment would be beneficial. Methods: Pre-cryopreservation (pre-cryo) and post-thaw graft characteristics were available on 423 UCBT performed at our institution between 2/11/2000 and 5/1/2007. The units were obtained from 16 US public cord blood banks and were selected by pre-cryo cell dose and HLA matching. Pre-cryo data (TNC, CD34 cells and CFU) was provided by the cord blood bank as part of routine banking practices. All units were thawed in the Duke Stem Cell Laboratory (SCL). Post-thaw testing (TNC, CD34, CFU) was performed by consistent personnel in the SCL after thaw and washing with Dextran/Albumin as described previously by Rubinstein et al. Univariate and multivariate analyses were performed to identify significant pre-cryo, post-thaw, and baseline factors predictive of neutrophil and platelet engraftment. Results: Of the 423 evaluable patients, 68% had malignancies, 61% were males, 73% were Caucasian and 38% were CMV+. The grafts were HLA (93%), sex (50%) or racially (24%) mismatched with the patients. There was excellent correlation between pre-cryo and post-thaw TNC (r2=0.92) and CD34 (r2=0.68) content, but much weaker correlation for CFUs (r2=0.27). In univariate analysis, age (≤5 years), disease (non-malignant), weight (≤12 kg), CMV status (negative), recipient ethnicity (Caucasian), HLA match (5/6 or 6/6) and pre-cryo/post-thaw TNC (larger), pre-cryo/post-thaw CD34 (larger) and pre-cryo/post-thaw CFU (larger) were predictive of both neutrophil and platelet engraftment. Multivariate analysis of parameters are presented in Table 1. In the overall multivariate analysis of neutrophil engraftment, Male units (p=0.01), 5/6 or 6/6 HLA match (p=0.02), larger post-thaw CD34 (p=0.02) and larger post-thaw CFU (<0.0001) were significant. For platelet engraftment, Caucasian recipients (p=0.006) and larger post-thaw CFU (p=0.002) were the only predictive parameters. Conclusions: Post-thaw CFUs are a strong independent predictor of neutrophil and platelet engraftment after UCBT. This assay could be tested on a CBU segment and used as a marker of potency for graft selection. Factors Predictive of Neutrophil and Platelet Engraftment in Multivariate Analysis of Graft/Recipient Characteristics. Neutrophil Engraftment Platelet Engraftment Pre−Cryopreservation Multivariate Model (p−value) CD34+ (0.0046), Recipient CMV (0.0138), CFU (0.0337), Unit Sex (0.0393) Recipient ethnicity (0.0052), TNC (0.0173), CFU (0.0324) Post−Thaw Multivariate Model (p−value) CFU (<0.0001), CD34 (0.0013), HLA match (0.0065) CFU (<0.0001), HLA match (0.0117), Recipient ethnicity (0.0135) Overall Multivariate Model (p−value) Post thaw CFU (<0.0001), Unit Sex (0.0131), HLA match (0.0186), Post thaw CD34 (0.02) Recipient ethnicity (0.0063), Post thaw CFU (0.002)

Low FFMI according to ESPEN cut-offs is a strong independent predictor of mortality in patients with COPD

2018 ◽  
Author(s):  
Irena Sarc ◽  
Tatjana Kosten ◽  
Tomaz Hafner ◽  
Barbara Zupanc ◽  
Kristina Ziherl
Keyword(s):  
Independent Predictor ◽  
Strong Independent Predictor

scholarly journals Endovascular treatment of blister aneurysms

2017 ◽  
Vol 42 (6) ◽  
pp. E12 ◽  
Author(s):  
Geoffrey W. Peitz ◽  
Christopher A. Sy ◽  
Ramesh Grandhi
Keyword(s):  
Endovascular Treatment ◽  
Treatment Options ◽  
Flow Diversion ◽  
Success Rates ◽  
Cerebrovascular Lesions ◽  
Promising Alternative ◽  
Treatment Methods ◽  
Aneurysm Occlusion ◽  
Open Surgical Treatment ◽  
Reconstructive Methods

Blister aneurysms are rare cerebrovascular lesions for which the treatment methods are reviewed here, with a focus on endovascular options. The reported pathogenesis of blister aneurysms varies, and hemodynamic stress, arterial dissection, and arteriosclerotic ulceration have all been described. There is consensus on the excessive fragility of blister aneurysms and their parent vessels, which makes clipping technically difficult. Open surgical treatment is associated with high rates of complications, morbidity, and mortality; endovascular treatment is a promising alternative. Among endovascular treatment options, deconstructive treatment has been associated with higher morbidity compared with reconstructive methods such as direct embolization, stent- or balloon-assisted direct embolization, stent monotherapy, and flow diversion. Flow diversion has been associated with higher technical success rates and similar clinical outcomes compared with non–flow diverting treatment methods. However, delayed aneurysm occlusion and the need for antiplatelet therapy are potential drawbacks to flow diversion that must be considered when choosing among treatment methods for blister aneurysms.

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