Association of sedentary work with colon and rectal cancer: systematic review and meta-analysis

ObjectivesThere has been no research on sedentary behaviour in the occupational domain that occupies a large portion of the daily life.MethodsWe conducted a meta-analysis to investigate the association between sedentary work and colorectal cancer. We searched PubMed, Embase and Cochrane databases up to 12 August 2020 for peer-reviewed journal articles that assessed the association between sedentary work and colon or rectal cancer. Pooled estimates of ORs were obtained using random effects models. Statistical tests for publication bias, heterogeneity and sensitivity analysis were applied.ResultsOf the 5 381 studies initially identified, 23 studies with 64 reports were eligible for inclusion. Sedentary work significantly increased the risk of colon cancer (pooled OR=1.21, 95% CI 1.11 to 1.31, p value ≤0.0001) and rectal cancer (pooled OR=1.08, 95% CI 1.00 to 1.16, p value=0.0395). The adjustment for leisure time physical activity attenuated the association and made the risk estimates non-significant for sedentary behaviour, but the association was independent of sex, control of body mass index and assessment of sedentary behaviour.ConclusionsWe found evidence of association between sedentary work and the risk of colon or rectal cancer. Limiting excessive sedentary work could be an important means of preventing colon and rectal cancer.

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Domain-specific physical activity and sedentary behaviour in relation to colon and rectal cancer risk: a systematic review and meta-analysis

International Journal of Epidemiology ◽

10.1093/ije/dyx137 ◽

2017 ◽

Vol 46 (6) ◽

pp. 1797-1813 ◽

Cited By ~ 33

Author(s):

Shahid Mahmood ◽

Robert J MacInnis ◽

Dallas R English ◽

Amalia Karahalios ◽

Brigid M Lynch

Keyword(s):

Physical Activity ◽

Systematic Review ◽

Rectal Cancer ◽

Cancer Risk ◽

Sedentary Behaviour ◽

Meta Analysis ◽

Domain Specific ◽

Colon And Rectal Cancer

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Reply: Comment on ‘Association of sedentary behaviour with colon and rectal cancer: a meta-analysis of observational studies’

British Journal of Cancer ◽

10.1038/bjc.2014.107 ◽

2014 ◽

Vol 111 (11) ◽

pp. 2203-2203

Author(s):

Z Lu ◽

S Cao ◽

Y Gan ◽

Y Cong

Keyword(s):

Rectal Cancer ◽

Sedentary Behaviour ◽

Observational Studies ◽

Meta Analysis ◽

Colon And Rectal Cancer

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Association of sedentary behaviour with colon and rectal cancer: a meta-analysis of observational studies

British Journal of Cancer ◽

10.1038/bjc.2013.709 ◽

2013 ◽

Vol 110 (3) ◽

pp. 817-826 ◽

Cited By ~ 48

Author(s):

Y J Cong ◽

Y Gan ◽

H L Sun ◽

J Deng ◽

S Y Cao ◽

...

Keyword(s):

Rectal Cancer ◽

Sedentary Behaviour ◽

Observational Studies ◽

Meta Analysis ◽

Colon And Rectal Cancer

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Long-term oncologic outcomes of transanal TME compared with transabdominal TME for rectal cancer: a systematic review and meta-analysis

Surgical Endoscopy ◽

10.1007/s00464-021-08615-7 ◽

2021 ◽

Author(s):

Jae Young Moon ◽

Min Ro Lee ◽

Gi Won Ha

Keyword(s):

Rectal Cancer ◽

Meta Analysis ◽

Disease Free Survival ◽

Distant Recurrence ◽

Oncologic Outcomes ◽

Cochrane Library ◽

Transanal Total Mesorectal Excision ◽

Random Effects Models ◽

The Cochrane Library

Abstract Background Transanal total mesorectal excision (TaTME) appears to have favorable surgical and pathological outcomes. However, the evidence on survival outcomes remains unclear. We performed a meta-analysis to compare long-term oncologic outcomes of TaTME with transabdominal TME for rectal cancer. Methods PubMed, EMBASE, and the Cochrane Library were searched. Data were pooled, and overall effect size was calculated using random-effects models. Outcome measures were overall survival (OS), disease-free survival (DFS), and local and distant recurrence. Results We included 11 nonrandomized studies that examined 2,143 patients for the meta-analysis. There were no significant differences between the two groups in OS, DFS, and local and distant recurrence with a RR of 0.65 (95% CI 0.39–1.09, I2 = 0%), 0.79 (95% CI 0.57–1.10, I2 = 0%), 1.14 (95% CI 0.44–2.91, I2 = 66%), and 0.75 (95% CI 0.40–1.41, I2 = 0%), respectively. Conclusion In terms of long-term oncologic outcomes, TaTME may be an alternative to transabdominal TME in patients with rectal cancer. Well-designed randomized trials are warranted to further verify these results.

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Safety and efficacy of endoscopic colonic stenting as a bridge to surgery in the management of intestinal obstruction due to left colon and rectal cancer: A systematic review and meta-analysis

Surgical Oncology ◽

10.1016/j.suronc.2012.10.003 ◽

2013 ◽

Vol 22 (1) ◽

pp. 14-21 ◽

Cited By ~ 121

Author(s):

Roberto Cirocchi ◽

Eriberto Farinella ◽

Stefano Trastulli ◽

Jacopo Desiderio ◽

Chiara Listorti ◽

...

Keyword(s):

Systematic Review ◽

Rectal Cancer ◽

Intestinal Obstruction ◽

Meta Analysis ◽

Left Colon ◽

Bridge To Surgery ◽

Safety And Efficacy ◽

Colonic Stenting ◽

Colon And Rectal Cancer

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Rectal Cancer: 20% Risk Reduction Thanks to Dietary Fibre Intake. Systematic Review and Meta-Analysis

Nutrients ◽

10.3390/nu11071579 ◽

2019 ◽

Vol 11 (7) ◽

pp. 1579 ◽

Cited By ~ 8

Author(s):

Vincenza Gianfredi ◽

Daniele Nucci ◽

Tania Salvatori ◽

Giulia Dallagiacoma ◽

Cristina Fatigoni ◽

...

Keyword(s):

Systematic Review ◽

Rectal Cancer ◽

Publication Bias ◽

Dietary Fibre ◽

Meta Analysis ◽

P Value ◽

Computer Search ◽

Fibre Intake ◽

Statistical Heterogeneity ◽

Dietary Fibre Intake

The aim of this systematic review and meta-analysis was to evaluate the association between dietary fibre intake and rectal cancer (RC) risk. In January 2019, a structured computer search on PubMed/Medline, Excerpta Medica dataBASE (EMBASE) and Scopus was performed for studies reporting the results of primary research evaluating dietary fibre intake in women and men as well as the risk of developing RC. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations were followed. Highest vs. lowest fibre concentrations was compared. The Egger test was used to estimate publication bias. Heterogeneity between studies was evaluated with I2 statistics. The search strategy identified 912 papers, 22 of which were included in our meta-analysis. Having evaluated a total of 2,876,136 subjects, the results suggest a protective effect of dietary fibre intake on RC prevention. The effect Size (ES) was [0.77 (95% CI = 0.66–0.89), p-value = 0.001)]. Moderate statistical heterogeneity (Chi2 = 51.36, df = 21, I2 = 59.11%, p-value = 0.000) was found. However, no publication bias was found, as confirmed by Egger’s linear regression test (Intercept −0.21, t = −0.24, p = 0.816). The findings suggest that dietary fibre intake could be protective against RC, with a clinically relevant reduction of RC risk. Identifying preventive measures to avoid the development of RC, especially by following a healthy lifestyle including healthy diet, is pivotal.

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