scholarly journals Rectal Cancer: 20% Risk Reduction Thanks to Dietary Fibre Intake. Systematic Review and Meta-Analysis

Nutrients ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1579 ◽  
Author(s):  
Vincenza Gianfredi ◽  
Daniele Nucci ◽  
Tania Salvatori ◽  
Giulia Dallagiacoma ◽  
Cristina Fatigoni ◽  
...  
Keyword(s):  
Systematic Review ◽  
Rectal Cancer ◽  
Publication Bias ◽  
Dietary Fibre ◽  
Meta Analysis ◽  
P Value ◽  
Computer Search ◽  
Fibre Intake ◽  
Statistical Heterogeneity ◽  
Dietary Fibre Intake

The aim of this systematic review and meta-analysis was to evaluate the association between dietary fibre intake and rectal cancer (RC) risk. In January 2019, a structured computer search on PubMed/Medline, Excerpta Medica dataBASE (EMBASE) and Scopus was performed for studies reporting the results of primary research evaluating dietary fibre intake in women and men as well as the risk of developing RC. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations were followed. Highest vs. lowest fibre concentrations was compared. The Egger test was used to estimate publication bias. Heterogeneity between studies was evaluated with I2 statistics. The search strategy identified 912 papers, 22 of which were included in our meta-analysis. Having evaluated a total of 2,876,136 subjects, the results suggest a protective effect of dietary fibre intake on RC prevention. The effect Size (ES) was [0.77 (95% CI = 0.66–0.89), p-value = 0.001)]. Moderate statistical heterogeneity (Chi2 = 51.36, df = 21, I2 = 59.11%, p-value = 0.000) was found. However, no publication bias was found, as confirmed by Egger’s linear regression test (Intercept −0.21, t = −0.24, p = 0.816). The findings suggest that dietary fibre intake could be protective against RC, with a clinically relevant reduction of RC risk. Identifying preventive measures to avoid the development of RC, especially by following a healthy lifestyle including healthy diet, is pivotal.

scholarly journals Dietary fibre intake and risk of stroke: A systematic review and meta-analysis of prospective studies

2012 ◽  
Vol 71 (OCE3) ◽  
Author(s):  
D. E. Threapleton ◽  
D. C. Greenwood ◽  
C. E. Evans ◽  
C. L. Cleghorn ◽  
C. Nykjaer ◽  
...  
Keyword(s):  
Systematic Review ◽  
Prospective Studies ◽  
Dietary Fibre ◽  
Meta Analysis ◽  
Fibre Intake ◽  
Dietary Fibre Intake

scholarly journals Dietary fibre intake and cardiovascular disease: A systematic review and meta-analysis of prospective studies

2012 ◽  
Vol 71 (OCE3) ◽  
Author(s):  
D. E. Threapleton ◽  
D. C. Greenwood ◽  
C. Evans ◽  
C. L. Cleghorn ◽  
C. Nykjaer ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cardiovascular Disease ◽  
Prospective Studies ◽  
Dietary Fibre ◽  
Meta Analysis ◽  
Fibre Intake ◽  
Dietary Fibre Intake

scholarly journals Dietary fibre intake and diabetes risk: a systematic review and meta-analysis of prospective studies

2013 ◽  
Vol 72 (OCE4) ◽  
Author(s):  
D. E. Threapleton ◽  
D. C. Greenwood ◽  
C. Evans ◽  
C. L. Cleghorn ◽  
C. Nykjaer ◽  
...  
Keyword(s):  
Systematic Review ◽  
Prospective Studies ◽  
Dietary Fibre ◽  
Meta Analysis ◽  
Diabetes Risk ◽  
Fibre Intake ◽  
Dietary Fibre Intake

scholarly journals Dietary fibre intake and risk of breast cancer: A systematic review and meta-analysis of epidemiological studies

Oncotarget ◽  
2016 ◽  
Vol 7 (49) ◽  
pp. 80980-80989 ◽  
Author(s):  
Sumei Chen ◽  
Yuanyuan Chen ◽  
Shenglin Ma ◽  
Ruzhen Zheng ◽  
Pengjun Zhao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Dietary Fibre ◽  
Meta Analysis ◽  
Epidemiological Studies ◽  
Fibre Intake ◽  
Dietary Fibre Intake

scholarly journals Association between Dietary Fibre Intake and Colorectal Adenoma: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 18 (8) ◽  
pp. 4168
Author(s):  
Daniele Nucci ◽  
Cristina Fatigoni ◽  
Tania Salvatori ◽  
Mariateresa Nardi ◽  
Stefano Realdon ◽  
...  
Keyword(s):  
Protective Effect ◽  
Colorectal Adenoma ◽  
Dietary Fibre ◽  
Meta Analysis ◽  
Fibre Intake ◽  
Negative Linear Correlation ◽  
Statistical Heterogeneity ◽  
Dietary Fibre Intake ◽  
Meta Regression Analysis ◽  
Meta Analyses

PubMed/Medline, Excerpta Medica dataBASE (EMBASE) and Scopus were searched in January 2021 in order to retrieve evidence assessing the association between dietary fibre intake and the risk of colorectal adenoma in adults. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used for the reporting of results. Only primary observational studies were included. Publication bias was estimated through the Egger’s test and the visual inspection of the funnel plot. Heterogeneity between studies was calculated with I2 statistics. The search strategy identified 683 papers, 21 of which were included in our meta-analysis. Having evaluated a total of 157,725 subjects, the results suggest a protective effect of dietary fibre intake against colorectal adenoma. Effect Size (ES) was [0.71 (95% CI = 0.68–0.75), p = 0.000)]. Moderate statistical heterogeneity (Chi2 = 61.68, df = 23, I2 = 62.71%, p = 0.000) was found. Findings show a statistically significant (p = 0.000) and robust association between a higher intake of dietary fibre and a lower risk of colorectal adenoma, considering both the prevalent and incident risk. Moreover, the meta-regression analysis showed a borderline significant negative linear correlation between the amount of dietary fibre intake and colorectal adenoma. Lastly, we performed a subgroup analysis by sex, showing a higher protective effect for men.

scholarly journals Dietary fibre intake and risk of cardiovascular disease: systematic review and meta-analysis

BMJ ◽  
2013 ◽  
Vol 347 (dec19 2) ◽  
pp. f6879-f6879 ◽  
Author(s):  
D. E. Threapleton ◽  
D. C. Greenwood ◽  
C. E. L. Evans ◽  
C. L. Cleghorn ◽  
C. Nykjaer ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cardiovascular Disease ◽  
Dietary Fibre ◽  
Meta Analysis ◽  
Fibre Intake ◽  
Dietary Fibre Intake

scholarly journals Performance of 18F-DCFPyL PET/CT Imaging in Early Detection of Biochemically Recurrent Prostate Cancer: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 11 ◽  
Author(s):  
Jiale Sun ◽  
Yuxin Lin ◽  
Xuedong Wei ◽  
Jun Ouyang ◽  
Yuhua Huang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Systematic Review ◽  
Early Detection ◽  
Publication Bias ◽  
Detection Rate ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Recurrent Prostate Cancer ◽  
Pet Ct ◽  
Statistical Heterogeneity

Background: Prostate-specific membrane antigen (PSMA)-targeted 2-(3-{1-carboxy-5-[(6-[18F] fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid (18F-DCFPyL) positron emission tomography/computed tomography (PET/CT) has shown advantages in primary staging, restaging, and metastasis detection of prostate cancer (PCa). However, little is known about the role of 18F-DCFPyL PET/CT in biochemically recurrent prostate cancer (BRPCa). Hence, we performed a systematic review and meta-analysis to evaluate 18F-DCFPyL PET/CT as first-line imaging modality in early detection of BRPCa.Methods: A comprehensive literature search of PubMed, Web of Science, Embase, and Cochrane Library was conducted until December 2020. The pooled detection rate on a per-person basis and together with 95% confidence interval (CI) was calculated. Furthermore, a prostate-specific antigen (PSA)-stratified performance of detection positivity was obtained to assess the sensitivity of 18F-DCFPyL PET/CT in BRPCa with different PSA levels.Results: A total of nine eligible studies (844 patients) were included in this meta-analysis. The pooled detection rate (DR) of 18F-DCFPyL PET/CT in BRPCa was 81% (95% CI: 76.9–85.1%). The pooled DR was 88.8% for PSA ≥ 0.5 ng/ml (95% CI: 86.2–91.3%) and 47.2% for PSA < 0.5 ng/ml (95% CI: 32.6–61.8%). We also noticed that the regional lymph node was the most common site with local recurrence compared with other sites (45.8%, 95% CI: 42.1–49.6%). Statistical heterogeneity and publication bias were found.Conclusion: The results suggest that 18F-DCFPyL PET/CT has a relatively high detection rate in BRPCa. The results also indicate that imaging with 18F-DCFPyL may exhibit improved sensitivity in BRPCa with increased PSA levels. Considering the publication bias, further large-scale multicenter studies are warranted for validation.

scholarly journals Dietary Fibre Intake in Relation to Asthma, Rhinitis and Lung Function Impairment—A Systematic Review of Observational Studies

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3594
Author(s):  
Emmanouela Sdona ◽  
Athina Vasiliki Georgakou ◽  
Sandra Ekström ◽  
Anna Bergström
Keyword(s):  
Systematic Review ◽  
Lung Function ◽  
Dietary Fibre ◽  
Observational Studies ◽  
Case Control ◽  
Cross Sectional ◽  
Fibre Intake ◽  
Function Impairment ◽  
Dietary Fibre Intake ◽  
Lung Function Impairment

A high intake of dietary fibre has been associated with a reduced risk of several chronic diseases. This study aimed to review the current evidence on dietary fibre in relation to asthma, rhinitis and lung function impairment. Electronic databases were searched in June 2021 for studies on the association between dietary fibre and asthma, rhinitis, chronic obstructive pulmonary disease (COPD) and lung function. Observational studies with cross-sectional, case–control or prospective designs were included. Studies on animals, case studies and intervention studies were excluded. The quality of the evidence from individual studies was evaluated using the RoB-NObs tool. The World Cancer Research Fund criteria were used to grade the strength of the evidence. Twenty studies were included in this systematic review, of which ten were cohort studies, eight cross-sectional and two case–control studies. Fibre intake during pregnancy or childhood was examined in three studies, while seventeen studies examined the intake during adulthood. There was probable evidence for an inverse association between dietary fibre and COPD and suggestive evidence for a positive association with lung function. However, the evidence regarding asthma and rhinitis was limited and inconsistent. Further research is needed on dietary fibre intake and asthma, rhinitis and lung function among adults and children.

scholarly journals Association of dietary fibre intake and gut microbiota in adults

2018 ◽  
Vol 120 (9) ◽  
pp. 1014-1022 ◽  
Author(s):  
Daniel Lin ◽  
Brandilyn A. Peters ◽  
Charles Friedlander ◽  
Hal J. Freiman ◽  
James J. Goedert ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Gut Microbiota ◽  
Dietary Fibre ◽  
Meta Analysis ◽  
Microbiota Composition ◽  
Fibre Intake ◽  
Dietary Fibre Intake ◽  
The Relationship ◽  
Gut Microbiota Composition

AbstractIncreasing evidence indicates that gut microbiota may influence colorectal cancer risk. Diet, particularly fibre intake, may modify gut microbiota composition, which may affect cancer risk. We investigated the relationship between dietary fibre intake and gut microbiota in adults. Using 16S rRNA gene sequencing, we assessed gut microbiota in faecal samples from 151 adults in two independent study populations: National Cancer Institute (NCI), n 75, and New York University (NYU), n 76. We calculated energy-adjusted fibre intake based on FFQ. For each study population with adjustment for age, sex, race, BMI and smoking, we evaluated the relationship between fibre intake and gut microbiota community composition and taxon abundance. Total fibre intake was significantly associated with overall microbial community composition in NYU (P=0·008) but not in NCI (P=0·81). In a meta-analysis of both study populations, higher fibre intake tended to be associated with genera of class Clostridia, including higher abundance of SMB53 (fold change (FC)=1·04, P=0·04), Lachnospira (FC=1·03, P=0·05) and Faecalibacterium (FC=1·03, P=0·06), and lower abundance of Actinomyces (FC=0·95, P=0·002), Odoribacter (FC=0·95, P=0·03) and Oscillospira (FC=0·96, P=0·06). A species-level meta-analysis showed that higher fibre intake was marginally associated with greater abundance of Faecalibacterium prausnitzii (FC=1·03, P=0·07) and lower abundance of Eubacterium dolichum (FC=0·96, P=0·04) and Bacteroides uniformis (FC=0·97, P=0·05). Thus, dietary fibre intake may impact gut microbiota composition, particularly class Clostridia, and may favour putatively beneficial bacteria such as F. prausnitzii. These findings warrant further understanding of diet–microbiota relationships for future development of colorectal cancer prevention strategies.

Sign in / Sign up

Export Citation Format

Share Document