scholarly journals Cardiogenic shock: evolving definitions and future directions in management

Open Heart ◽  
2019 ◽  
Vol 6 (1) ◽  
pp. e000960 ◽  
Author(s):  
Tara L Jones ◽  
Kenta Nakamura ◽  
James M McCabe
Keyword(s):  
Cardiogenic Shock ◽  
Vicious Cycle ◽  
Compensatory Mechanisms ◽  
Future Directions ◽  
Algorithmic Approach ◽  
Optimal Outcomes ◽  
Trial Experience ◽  
Clinical Trial Experience ◽  
Systemic Process ◽  
Contemporary Management

Cardiogenic shock (CS) is a complex and highly morbid entity conceptualised as a vicious cycle of injury, cardiac and systemic decompensation, and further injury and decompensation. The pathophysiology of CS is incompletely understood but limited clinical trial experience suggests that early and robust support of the failing heart to allow for restoration of systemic homoeostasis appears critical for survival. We review the pathophysiology, clinical features and trial data to construct a contemporary model of CS as a systemic process characterised with maladaptive compensatory mechanisms requiring prompt and appropriately tailored medical and mechanical support for optimal outcomes. We conclude with an algorithmic approach to acute CS incorporating clinical and haemodynamic data to match the patient’s cardiac and systemic needs as a template for contemporary management.

scholarly journals Patients’ understanding of clinical research: An Italian cancer patient survey

2018 ◽  
Vol 105 (1) ◽  
pp. 31-37
Author(s):  
Britt Rudnas ◽  
Emanuela Montanari ◽  
Monia Dall’Agata ◽  
Elisabetta Petracci ◽  
Oriana Nanni
Keyword(s):  
Clinical Research ◽  
Response Rate ◽  
Medical Oncology ◽  
Patient Survey ◽  
Research Knowledge ◽  
Patients With Cancer ◽  
Trial Experience ◽  
Clinical Trial Experience ◽  
Previous Clinical Trial ◽  
Level Of Knowledge

Introduction: Patients’ awareness of clinical research and their involvement in clinical trials is of great importance, but it is difficult to estimate the extent of knowledge on the research being undertaken. Methods: We evaluated the level of knowledge about clinical research using a self-reporting survey distributed to 967 adult patients with cancer attending the Departments of Medical Oncology and Onco-Haematology Units of IRST IRCCS and 4 hospitals in the region of Emilia-Romagna, Italy. The questionnaire was composed of 10 specific items on research knowledge. Patients responding correctly to at least 8 of the 10 items were considered to have a good understanding of clinical research. Results: The questionnaire was completed by 769 patients (response rate 79.5%). Only 19% of patients were found to have a good understanding of clinical research. Patients with higher education and those who had previous clinical trial experience showed a significantly better understanding. Fifty-three percent of patients said that they would be willing to participate in a trial studying a new drug and 75% expressed an interest in taking part in informative meetings/events about clinical studies. Conclusions: Our results show that patients’ understanding of clinical research is limited and highlight an interest in learning more.

scholarly journals Correction to: Liver Safety of Fasiglifam (TAK-875) in Patients with Type 2 Diabetes: Review of the Global Clinical Trial Experience

Drug Safety ◽  
2018 ◽  
Vol 41 (12) ◽  
pp. 1431-1437 ◽  
Author(s):  
John F. Marcinak ◽  
Melvin S. Munsaka ◽  
Paul B. Watkins ◽  
Takashi Ohira ◽  
Neila Smith
Keyword(s):  
Type 2 Diabetes ◽  
Clinical Trial ◽  
Liver Safety ◽  
Trial Experience ◽  
Global Clinical Trial ◽  
Clinical Trial Experience

scholarly journals Treating cocaine addiction: From preclinical to clinical trial experience with ?-vinyl GABA

Synapse ◽  
2003 ◽  
Vol 50 (3) ◽  
pp. 261-265 ◽  
Author(s):  
Jonathan D. Brodie ◽  
Emilia Figueroa ◽  
Stephen L. Dewey
Keyword(s):  
Clinical Trial ◽  
Cocaine Addiction ◽  
Trial Experience ◽  
Clinical Trial Experience

scholarly journals Contemporary Clinical Management of the Cerebral Complications of Preeclampsia

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Stefan C. Kane ◽  
Alicia Dennis ◽  
Fabricio da Silva Costa ◽  
Louise Kornman ◽  
Shaun Brennecke
Keyword(s):  
Clinical Management ◽  
Neurological Complications ◽  
Evidence Base ◽  
Morbidity And Mortality ◽  
Future Directions ◽  
Neurological Sequelae ◽  
Cerebral Complications ◽  
Contemporary Management

The neurological complications of preeclampsia and eclampsia are responsible for a major proportion of the morbidity and mortality arising from these conditions, for women and their infants alike. This paper outlines the evidence base for contemporary management principles pertaining to the neurological sequelae of preeclampsia, primarily from the maternal perspective, but with consideration of fetal and neonatal aspects as well. It concludes with a discussion regarding future directions in the management of this potentially lethal condition.

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