scholarly journals Patients’ understanding of clinical research: An Italian cancer patient survey

2018 ◽  
Vol 105 (1) ◽  
pp. 31-37
Author(s):  
Britt Rudnas ◽  
Emanuela Montanari ◽  
Monia Dall’Agata ◽  
Elisabetta Petracci ◽  
Oriana Nanni
Keyword(s):  
Clinical Research ◽  
Response Rate ◽  
Medical Oncology ◽  
Patient Survey ◽  
Research Knowledge ◽  
Patients With Cancer ◽  
Trial Experience ◽  
Clinical Trial Experience ◽  
Previous Clinical Trial ◽  
Level Of Knowledge

Introduction: Patients’ awareness of clinical research and their involvement in clinical trials is of great importance, but it is difficult to estimate the extent of knowledge on the research being undertaken. Methods: We evaluated the level of knowledge about clinical research using a self-reporting survey distributed to 967 adult patients with cancer attending the Departments of Medical Oncology and Onco-Haematology Units of IRST IRCCS and 4 hospitals in the region of Emilia-Romagna, Italy. The questionnaire was composed of 10 specific items on research knowledge. Patients responding correctly to at least 8 of the 10 items were considered to have a good understanding of clinical research. Results: The questionnaire was completed by 769 patients (response rate 79.5%). Only 19% of patients were found to have a good understanding of clinical research. Patients with higher education and those who had previous clinical trial experience showed a significantly better understanding. Fifty-three percent of patients said that they would be willing to participate in a trial studying a new drug and 75% expressed an interest in taking part in informative meetings/events about clinical studies. Conclusions: Our results show that patients’ understanding of clinical research is limited and highlight an interest in learning more.

scholarly journals Knowledge, perception and screening of local dye workers regarding urinary bladder cancer in Ghana

2020 ◽  
Vol 26 (1) ◽  
Author(s):  
Babatunde M. Duduyemi ◽  
Divine Lardey Agyemang ◽  
Ernest Adankwah ◽  
Hannah Nyarko ◽  
Derrick Andoh
Keyword(s):  
Bladder Cancer ◽  
Urinary Bladder ◽  
Educational Level ◽  
Response Rate ◽  
Urinary Bladder Cancer ◽  
Clinical History ◽  
Level Of Knowledge ◽  
Knowledge Levels ◽  
Cancerous Cells ◽  
Structured Questionnaire

Abstract Background Cancer is the leading cause of death with 7.6 million deaths worldwide annually. About 19% of bladder cancer cases are attributed to environmental and occupational factors. The knowledge of any disease is very vital in the control or prevention of such disease. This study examined the knowledge and perception of urinary bladder cancer among 104 local dye workers in Ghana (Kumasi, Koforidua and Somanya). Methods A well-structured questionnaire was used to measure participants’ knowledge and perception towards bladder cancer. Forty out of the 104 participants were recruited to provide their urine samples for cytomorphological study. Thin smears were prepared and stained with Papanicolaou stain. Respondents were selected based on clinical history and working experience. Result The response rate to the questionnaires was 100% of the 104 respondents interviewed. The respondents had a mean age of 26 years. Overall, about 10% of the respondents in this study had good knowledge levels on bladder cancer and 16% had good perception of the disease. There was a significant correlation between knowledge and educational level of the participants (p < 0.001). Report of the cytomorphological study indicates that none of the samples of the participants screened had cancerous cells. Conclusion The findings suggest that level of knowledge about bladder cancer among local dye workers in this study was low, while their level of perception was just above average.

Junior doctors' experience and knowledge of procedures in compulsory psychiatric admissions in Ireland

2001 ◽  
Vol 18 (1) ◽  
pp. 21-23 ◽  
Author(s):  
Geraldine Swift ◽  
M Nasir ◽  
John D Sheehan ◽  
Patricia R Casey
Keyword(s):  
Response Rate ◽  
Real Life ◽  
Current Debate ◽  
Junior Doctors ◽  
Legal Requirements ◽  
Training Scheme ◽  
Psychiatric Admissions ◽  
Mental Health Legislation ◽  
Level Of Knowledge ◽  
Health Legislation

AbstractObjectives: Prompted by the current debate in Ireland regarding involuntary detention, we undertook a survey of psychiatric trainees to examine their level of knowledge of the legislation governing such admissions.Method: Eighty psychiatric trainees working in centres affiliated to a particular training scheme were invited to complete a purpose-designed instrument.Results: Response rate was 52/80. Trainees were well informed concerning the procedures necessary to initiate detention. Their knowledge of the legal indications for involuntary detention and restrictions on its duration was patchy.Conclusions: We suggest that training in the area of mental health legislation needs to be increased and to focus on satisfying legal requirements in real-life scenarios.

scholarly journals Corrigendum

2018 ◽  
Vol 12 (4) ◽  
pp. 349-349
Keyword(s):  
Clinical Research ◽  
Nutritional Supplements ◽  
Patient Survey ◽  
Executive Board ◽  
Cardiovascular Parameter ◽  
Lifestyle Medicine ◽  
Non Profit ◽  
Nutritional Interventions ◽  
Health Related

Fuhrman J. Dietary Protocols to Maximize Disease Reversal and Long-Term Safety. American Journal of Lifestyle Medicine. 2015; 9: 343-353. Original DOI: 10.1177/1559827615580971 Fuhrman J, Michael S. Improved Cardiovascular Parameter with a Nutrient-Dense, Plant-Rich Diet-Style: A Patient Survey with Illustrative Cases. American Journal of Lifestyle Medicine. 2017; 11: 264-273. Original DOI: 10.1177/1559827615611024 In the above articles, the author disclosed the following financial relationships: The author maintains a website at https://www.drfuhrman.com , which sells nutritional supplements and other health-related products. The author also serves on the Executive Board of the Nutritional Research Foundation, a non-profit that promotes clinical research that includes nutritional interventions on chronic diseases, and includes the Fuhrman Longevity Society among its initiatives. More information is available at its website at https://www.nutritionalresearch.org .

scholarly journals Recent Findings in the Posttranslational Modifications of PD-L1

2020 ◽  
Vol 2020 ◽  
pp. 1-7 ◽  
Author(s):  
Shu-Man Li ◽  
Jie Zhou ◽  
Yun Wang ◽  
Run-Cong Nie ◽  
Jie-Wei Chen ◽  
...  
Keyword(s):  
Posttranslational Modifications ◽  
Immune Checkpoint ◽  
Protein Modification ◽  
Immune Cell ◽  
Response Rate ◽  
Malignant Tumors ◽  
Objective Response ◽  
Cell Activity ◽  
Patients With Cancer ◽  
L1 Protein

Immune checkpoint therapy, such as the reactivation of T-cell activity by targeting programmed cell death 1 (PD-1) and its ligand PD-L1 (also called B7-H1 and CD274) has been found pivotal in changing the historically dim prognoses of malignant tumors by causing durable objective responses. However, the response rate of immune checkpoint therapy required huge improvements. It has been shown that the expression of PD-L1 on cancer cells and immune cell membranes is correlated with a more durable objective response rate to PD-L1 antibodies, which highlights the importance of deeply understanding how this protein is regulated. Posttranslational modifications such as phosphorylation, N-glycosylation, and ubiquitination of PD-L1 have emerged as important regulatory mechanisms that modulate immunosuppression in patients with cancer. In this review, we summarized the latest findings of PD-L1 protein modification and their clinical applications.

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