scholarly journals Intramuscular injection of procaine penicillin combined with oral administration of chloramphenicol in the treatment of gonorrhoea.

1966 ◽  
Vol 42 (2) ◽  
pp. 107-109
Author(s):  
H C Gjessing ◽  
K Odegaard
Keyword(s):  
Oral Administration ◽  
Intramuscular Injection ◽  
Procaine Penicillin

Effect of Intramuscular Administration of Antibiotics on the Oxygen Consumption of Normal and Hyperthyroid Rats

1957 ◽  
Vol 192 (1) ◽  
pp. 73-75 ◽  
Author(s):  
G. R. Vogel ◽  
S. M. Hauge ◽  
F. N. Andrews
Keyword(s):  
Oxygen Consumption ◽  
Oral Administration ◽  
Intramuscular Injection ◽  
Endocrine System ◽  
Penicillin G ◽  
Albino Rats ◽  
Stomach Tube ◽  
Procaine Penicillin ◽  
Before And After ◽  
Rate Of Oxygen Consumption

The oxygen consumption of normal and hyperthyroid albino rats was measured before and after the intramuscular injection of 1.2 mg (0.2 ml of solution) of procaine penicillin G, Aureomycin or Ilotycin. The final measurements were observed at either 1- or 3-hour intervals after the injection. The antibiotics caused a statistically significant decrease in the rate of oxygen consumption in both normal and hyperthyroid rats. This effect diminished with time. Similar effects were observed with procaine penicillin G after oral administration by stomach tube. It is suggested that antibiotics may somehow influence the endocrine system, possibly the level of circulating thyroxin. Such studies are in progress.

STUDIES OF PENICILLIN IN PEDIATRICS

PEDIATRICS ◽  
1950 ◽  
Vol 5 (4) ◽  
pp. 664-671
Author(s):  
B. M. KAGAN ◽  
M. NIERENBERG ◽  
D. GOLDBERG ◽  
A. MILZER
Keyword(s):  
Intramuscular Injection ◽  
Room Temperature ◽  
Serum Levels ◽  
Sesame Oil ◽  
Peanut Oil ◽  
Penicillin G ◽  
Procaine Penicillin ◽  
Pertinent Data ◽  
Significant Difference ◽  
Pediatric Use

Table I summarizes most of the pertinent data in this report on the serum penicillin concentrations 12 and 24 hours after intramuscular injection of K penicillin G in peanut oil and beeswax, which is fluid at room temperature, and of three different procaine penicillin preparations. These three preparations are procaine penicillin G in sesame oil, procaine penicillin G in peanut oil with 2% aluminum monostearate, and procaine penicillin G in water with Na-carboxymethylcellulose. When they were given in a dosage of 8000 u./lb. to infants and children, weighing between 4.5 and 18.0 kg., there was no statistically significant difference in the serum levels obtained. A dosage schedule for these preparations is suggested for pediatric use. The aqueous preparation offers some advantages which are discussed. Experiences are reported which emphasize the necessity of avoiding intravenous administration of all these preparations.

BLOOD LEVELS OF SYNTHETIC GLUCOCORTICOIDS AFTER ADMINISTRATION BY VARIOUS ROUTES

1979 ◽  
Vol 82 (1) ◽  
pp. 149-157 ◽  
Author(s):  
YUKITAKA MIYACHI ◽  
HIDEKI YOTSUMOTO ◽  
TAKASHI KANO ◽  
AKIRA MIZUCHI ◽  
TETSUICHIRO MUTO ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Liver Disease ◽  
Oral Dose ◽  
Oral Administration ◽  
Intramuscular Injection ◽  
Peak Serum ◽  
Blood Levels ◽  
Serum Concentrations ◽  
Synthetic Glucocorticoids ◽  
Synthetic Glucocorticoid

SUMMARY Using reliable radioimmunoassay methods, the concentrations of prednisolone, prednisolone-hemisuccinate, betamethasone and betamethasone-17-benzoate were determined after administration by various routes. Serum prednisolone and betamethasone concentrations increased to peak levels 2 h after oral administration and then decreased gradually. The half-times of disappearance of prednisolone and betamethasone from blood, after a single oral dose, were both approximately 180–220 min. Five to fifteen minutes after intramuscular injections of 20 mg prednisolone-hemisuccinate the peak serum concentration was 63·7 ± 7·4 μg/ 100 ml and 30 min later plasma unesterified prednisolone reached its highest level (28·8 ± 2·6 μg/100 ml). The administration of steroids through the rectum induced gradual increases in the levels of serum steroids, reaching a maximum of 25% of the peak serum concentrations observed after oral administration. Plasma betamethasone-17-benzoate levels of 300 ng/ 100 ml were observed after topical application of betamethasone-17-benzoate gel to the skin. In patients with liver disease, the clearance of betamethasone was very slow compared with that in normal control subjects and significant amounts were retained in the blood 24 h after oral administration, showing that the liver is the most important organ for the metabolism of synthetic glucocorticoid. The concentrations of prednisolone and prednisolone-hemisuccinate in the cerebrospinal fluid were very low after the intramuscular injection of prednisolone-hemisuccinate, confirming the relative impermeability of the blood–brain barrier to polar steroids.

Effect of Dose Formulation on Isoniazid Absorption in Two Young Children

PEDIATRICS ◽  
1986 ◽  
Vol 77 (6) ◽  
pp. 850-852
Author(s):  
Daniel A. Notterman ◽  
Michael Nardi ◽  
Judy G. Saslow
Keyword(s):  
Oral Administration ◽  
Treatment Failure ◽  
Tuberculous Meningitis ◽  
Intramuscular Injection ◽  
Apple Juice ◽  
Plasma Concentrations ◽  
Pharmacokinetic Studies ◽  
Measured Concentration ◽  
Apple Sauce ◽  
Crushed Tablet

In an 8-month-old infant with tuberculous meningitis treatment with isoniazid was unsuccessful and was associated with lower than expected plasma concentrations of isoniazid (measured concentration 0.1 µg/mL). The infant had received isoniazid as a crushed tablet admixed with apple sauce. Oral administration of the parenteral solution of isoniazid (Nydrazid, Squibb) mixed in apple juice produced a higher isoniazid concentration (2.9 µg/mL) and the child improved clinically. Pharmacokinetic studies in two subjects were performed following intramuscular injection of isoniazid and oral administration of (1) an isoniazid tablet crushed and mixed with apple sauce, (2) parenteral isoniazid solution mixed with apple juice, and (3) a commercially available syrup containing isoniazid and pyridoxine (P-I-N Forte, Lannett). Of the three oral preparations, the syrup produced the highest peak concentrations (8.3 and 6.9 µg/mL). The crushed tablet in apple sauce produced the lowest peak concentrations (1.4 and 2.4 µg/mL). Administration of crushed isoniazid tablets with food may be associated with impaired gastrointestinal absorption, lower than expected isoniazid concentrations, and treatment failure.

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