Resolution of sclerosing encapsulating peritonitis in a young dog

2020 ◽  
Vol 8 (1) ◽  
pp. e001022
Author(s):  
Ingrid Isaac ◽  
Ines Carrera ◽  
Juan Martí ◽  
Andrea DiBella
Keyword(s):  
Small Volume ◽  
Clinical Signs ◽  
Free Fluid ◽  
Abdominal Ultrasonography ◽  
Sclerosing Encapsulating Peritonitis ◽  
Abdominal Organs ◽  
Peritoneal Effusion ◽  
Encapsulating Peritonitis

An eight-month-old Labrador retriever presented with abdominal effusion. Abdominal ultrasonography revealed significant free fluid and a linear hyperechoic band surrounding the abdominal organs. CT showed the gastrointestinal organs to be located centrally, enclosed by a thin, hyperattenuating enhanced band with no peritoneal effusion in this region. Surgery was performed to obtain biopsies for diagnostic purposes. Histopathology revealed granulation tissue with reactive fibroblasts, lymphoplasmacytic inflammation and neovascularisation; these findings were consistent with the diagnosis of secondary sclerosing encapsulating peritonitis. The patient responded well to treatment with tamoxifen, prednisolone and spironolactone. Four months later, follow-up abdominal ultrasonography revealed a small volume of free fluid. However, there was a mild adverse reaction to tamoxifen, causing protrusion of the penis and attraction of other dogs. Two and a half years after diagnosis, the patient continued to have good quality-of-life with no clinical signs or relapse.

Antibodies to Leishmania infantum in peritoneal effusion from a dog with atypical signs of leishmaniosis: treatment and follow-up

2020 ◽  
Vol 8 (2) ◽  
pp. e001144
Author(s):  
Sergio Villanueva-Saz ◽  
Cristina Peréz Sala ◽  
Andrés Yzuel Estévez ◽  
Antonio Fernández ◽  
María Teresa Verde
Keyword(s):  
Leishmania Infantum ◽  
Peritoneal Fluid ◽  
Clinical Signs ◽  
Abdominal Distension ◽  
Canine Leishmaniosis ◽  
Abdominal Ultrasonography ◽  
Abdominal Radiology ◽  
Peritoneal Effusion ◽  
French Bulldog

A three-year-old entire male French bulldog was brought in with the following clinical signs: apathy, vomiting and abdominal distension. Physical examination showed dehydration, tachypnoea and presence of jaundice. Abdominal radiology revealed the presence of an important loss of details in the abdominal structures compatible with peritoneal effusion, confirmed by abdominal ultrasonography. Findings detected by ultrasonography consisted of splenomegaly with alteration of the echotexture, hepatomegaly with presence of nodules and irregular areas in the liver capsule. An ultrasound-guided sample of the peritoneal fluid was taken for laboratory analysis. Abnormal clinicopathological results included pancytopenia, hyperglobulinaemia, hypoalbuminaemia, and elevation of the hepatic parameters and total bilirubin. High antibodies to Leishmania infantum were detected by ELISA in serum and peritoneal fluid samples. However, PCR for L infantum showed a negative result from the peritoneal fluid sample. This is the first reported case of canine leishmaniosis with the specific detection of L infantum antibodies in peritoneal effusion.

scholarly journals Study of Treatment Complications in Oncology / Hematology Patients: Protocol for a Prospective and Interventional Cohort Study from the Pasca Program

Blood ◽  
2020 ◽  
Vol 136 (Supplement 1) ◽  
pp. 10-11
Author(s):  
Mauricette Michallet ◽  
Romain Buono ◽  
Mohamad Sobh ◽  
Solene Poirey ◽  
Emmanuelle Nicolas-Virelizier ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cohort Study ◽  
Research Funding ◽  
Patient Management ◽  
Clinical Signs ◽  
Sexual Disorders ◽  
Management Of Complications ◽  
Physical Deconditioning

Introduction In France, cancer incidence is increasing, reaching approximately 400,000 new cases in 2017. Thanks to diagnostic and therapeutic advances, net survival at 5 years is improving, with a corollary increase in the number of survivors. Among survivors, 44% have a poor quality of life due to the more or less late onset of treatment-related complications. Despite the objectives of the 2014-2019 national cancer plan considering the latest therapeutic advances, very few initiatives integrating systematic, early detection and management of complications exist in France. Methods and analysis PASCA (Care pathways through cancer) is a single-arm, interdisciplinary, prospective, interventional, cohort study. During a period of 24 months, it is intended to include 858 adults aged 18 to 65 years with non-Hodgkin and Hodgkin lymphoma, acute myeloid leukemia, testicular germ cell tumor, non-metastatic invasive breast cancer, soft tissue sarcoma, osteosarcoma or Ewing's sarcoma at Centre Leon Berard (Lyon, France). The program consists on exhaustive identification of 22 complications at 1 month, 6 months, 24 months and 60 months after the end of first line treatment: social precariousness, return-to-work issues, cognitive problems, anxiety and depression disorders, chronic fatigue, physical deconditioning, overweight/obesity, chronic pain, dermatological disorders, gastrointestinal disorders, sexual disorders, hypogonadism, premature ovarian failure, osteoporosis, chronic kidney failure, heart failure, coronary heart disease, respiratory failure, hypothyroidism, lymphedema, modifiable risk factors associated with the occurrence of secondary cancers. Each identification will give rise to management, which consists of referring the patient to a healthcare professional belonging to the network of dedicated healthcare professionals at the regional level. The course of action to be followed will be defined using decision trees based on international, national or learned society recommendations. Referral outside Centre Leon Berard will be made to a specialist doctor, a health professional from the paramedical field or the patient's general practitioner who will confirm the diagnosis and initiate patient management and follow-up. These patients will also benefit from their usual follow-up in the context of their initial malignancy. Each study visit will include a search for clinical signs using questionnaires, an assay of 12 biological parameters, a urine test strip, 5 tests evaluating physical deconditioning and an electrocardiogram. The weight, height, waist circumference, blood pressure will also be measured. Primary outcome will be the incidence of the 22 complications, measured at 1 month, 6 months, 24 months and 60 months after the end of intensive chemotherapy treatment. Ethics and dissemination The study protocol was approved by the French ethics committee (Comité de protection des personnes Ile de France IV), the study database is currently being declared and registered to the Commission Nationale de l'Informatique et des Libertés (CNIL) and the study on ClinicalTrials.gov. The results will be disseminated to patients and in peer-reviewed journals and academic conferences. Strengths and limitations of this study This study is based on a previous feasibility study with 52 patients recruited in onco-hematology, which demonstrated the feasibility of the intervention and the existence of patient management needs.(1) The study design does not include a comparator arm, as the objective of the study is to provide a comprehensive picture of treatment-related complications, especially those that appear over the long term. Due to the lack of recent data concerning some complications, sample size was calculated empirically on the basis of the active queue of patients at the Centre Leon Berard. References Michallet M, Sobh M, Buono R, Poirey S, Pascu I, Nicolas-Virelizier E, et al. Personalised Follow-up Program after Acute Phase of Treatment in Oncology/Hematology Patients Towards Early Intervention, Better Care and Quality of Life Improvement: Results from Pasca Pilot Study. Blood. 13 nov 2019;134(Supplement_1):5817-5817. Disclosures Nicolini: Sun Pharma Ltd: Consultancy; Incyte: Research Funding, Speakers Bureau; Novartis: Research Funding, Speakers Bureau.

Intestinal lymphoma in a Boxer breed dog – case report

2019 ◽  
Vol XXIV (142) ◽  
pp. 72-82
Author(s):  
Sayonara da Luz Ferro ◽  
Fernanda Jönck ◽  
Marta Cristina T. Heckler ◽  
Ewerton Cardoso ◽  
Mateus Rychescki ◽  
...  
Keyword(s):  
Weight Loss ◽  
Abdominal Cavity ◽  
Clinical Signs ◽  
Exploratory Laparotomy ◽  
Needle Aspiration ◽  
Free Fluid ◽  
Intestinal Lymphoma ◽  
Mesenteric Lymph Nodes ◽  
Abdominal Ultrasonography ◽  
Tissue Biopsy

Intestinal lymphoma is the second most common form of lymphoma in dogs. It is characterized by the presence of neoplastic lymphocytes in the gastrointestinal tract or mesenteric lymph nodes. The chief clinical signs are vomiting, diarrhea, anorexia and weight loss. The diagnosis is made through fine needle aspiration and cytology, or by tissue biopsy and histopathology, and chemotherapy is the treatment of choice. We report a case of intestinal lymphoma in a five years old Boxer, presented with history of hematochezia and lethargy of 7 days duration, and 20 days of anorexia and persistent weight loss. Abdominal ultrasonography revealed free fluid in the abdominal cavity, and an intestinal mass. Exploratory laparotomy was performed and a tissue biopsy was performed. Histopathology confirmed the diagnosis of intestinal lymphoma, but the patient died during the surgical procedure.

scholarly journals Zdravljenje glavkoma in suho oko

2016 ◽  
Vol 85 (4) ◽  
Author(s):  
Barbara Cvenkel
Keyword(s):  
Ocular Surface ◽  
Clinical Signs ◽  
Tear Film ◽  
Signs And Symptoms ◽  
Surface Damage ◽  
Eye Drops ◽  
Film Instability ◽  
Asymptomatic Patients

Patients with glaucoma have increased prevalence of dry eye (DE) compared to age-matched population without glaucoma. Clinical presentation of DE varies among individuals and may significantly reduce quality of life. The onset and deterioration of DE is caused by the toxic-inflammatory effects of preservatives in eye drops, active substance itself, and added, pharmacologically inactive substances or excipients. Ocular surface changes most frequently include superficial punctate keratitis, tear film instability, and allergic reactions. Despite the lack of symptoms, clinical signs may indicate ocular surface damage. Discordance between signs and symptoms is partly caused by decreased corneal sensitivity induced by neurotoxicity of the preservative benzalkonium chloride (BAK). Therefore, it is important to evaluate ocular surface before initiating glaucoma therapy and during follow-up also in asymptomatic patients. Preservative-free and/or BAK-free therapy is indicated in patients with severe DE and allergy to preservatives, and recommended in patients with DE of moderate severity, blepharitis, in symptomatic patients, before filtering surgery to reduce preoperative inflammation, in those with moderate fluorescein staining of grade 2 on Oxford scheme, and reduced tear film break-up time.

scholarly journals Difficult to Diagnose the Cause of Intestinal Obstruction due to Abdominal Cocoon Syndrome

2021 ◽  
Author(s):  
Cemal Ulusoy ◽  
Andrej Nikolovski ◽  
Nazım Öztürk
Keyword(s):  
Small Bowel ◽  
Intestinal Obstruction ◽  
Small Bowel Obstruction ◽  
Abdominal Mass ◽  
Clinical Signs ◽  
Rare Condition ◽  
Abdominal Cocoon ◽  
Sclerosing Encapsulating Peritonitis ◽  
Encapsulating Peritonitis ◽  
Palpable Abdominal Mass

Abdominal cocoon syndrome (sclerosing encapsulating peritonitis) is a rare condition associated with clinical signs of intestinal dysfunction, episodes of small bowel obstruction and sometimes a palpable abdominal mass. We present the case of a 46-year-old male patient with clinical signs of intestinal obstruction caused by primary sclerosing encapsulating peritonitis.

Systematic Review of Pharmacologic and Compression Therapies for Treatment of Post-Thrombotic Syndrome

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 4207-4207
Author(s):  
Jacqueline M. Cohen ◽  
Elie A. Akl ◽  
Susan R. Kahn
Keyword(s):  
Quality Of Life ◽  
Venous Insufficiency ◽  
Conflicts Of Interest ◽  
Treatment Success ◽  
Clinical Signs ◽  
Duration Of Treatment ◽  
Post Thrombotic Syndrome ◽  
Quality Evidence

Abstract Abstract 4207 Background: Post-thrombotic syndrome (PTS) is a chronic complication of deep venous thrombosis (DVT) characterized by chronic pain, swelling and other signs in the affected limb that can severely impact individuals' quality of life. There are no widely accepted treatments for PTS, although varied treatment strategies have been proposed. Objective: To systematically review evidence for the effectiveness and safety of pharmacologic and compression therapies for treatment of PTS. Methods: Randomized controlled trials (RCTs) of PTS treatments were sought in a search of PubMed and by reverse citation searches. Results: A total of 121 titles were reviewed and 12 full-text publications were assessed for inclusion. Seven trials were selected for inclusion in the review. Four trials (3 parallel RCTs, 1 crossover RCT) including 521 patients assessed the effectiveness of various drugs for treatment of PTS. These pharmacotherapies included rutosides, hidrosmin, and defibrotide and treatment durations ranged from 2–12 months. Three trials (1 parallel RCT, 2 crossover RCTs) including 82 patients assessed compression therapies. Two used intermittent pneumatic compression (IPC) devices worn for 4–8 weeks, while one used continuous compression in the form of graduated compression stockings (GCS) worn for at least 1 year. Follow-up in these studies ranged from 8 weeks to over 1 year. All studies identified PTS as occurring after DVT in the same leg, often requiring objective diagnosis of DVT. One study used CEAP criteria for venous insufficiency, including patients classified as C2, C3 or C4. Another required participants to have had deep venous insufficiency (not further defined) for at least 12 months. Two studies used the Villalta scale to classify patients as having PTS, while one study only included patients with a score >14, corresponding to severe PTS. Another study defined PTS as the presence of chronic and typical pain and swelling 1 year post-DVT, and another defined it as intractable symptoms causing significant limitations of lifestyle and/or morbidity. In one study, PTS was not defined. Indicators used to assess the success of the interventions varied. Clinical signs and symptoms were often assessed with a quantitative scoring system. Validated scales used included Kakkar & Lawrence, Villalta, and VEINES-Sym. Calf and ankle circumference were often measured, where significant differences in these measures were used to attest to the success of an intervention; however, the clinical significance of these changes may be questionable. The IPC studies defined treatment success based on factors such as perceived benefit, patient preference for the active treatment, and willingness to continue to use the intervention. The GCS study defined treatment failure based on symptom deterioration, work absences, and development of venous ulcer. Only 1 study assessed the effect on quality of life, using the VEINES-QOL questionnaire. Studies of pharmacotherapies demonstrated minimal benefit on symptom scores, reduced calf and ankle circumference, and ulcer healing. In one study that continued to follow-up subjects for 6 months after treatment was terminated, the effect of drug treatment was not sustained (50% of ulcers returned). Studies of compression therapy did not convincingly demonstrate benefits of GCS; but for the IPC devices, treatment success was more likely than on the placebo devices. None of these treatments were associated with any important side effects and hence, compliance was acceptable in all studies that reported it. Studies of pharmacologic and compression therapies for treatment of PTS suffer from study design limitations including lack of blinding and wash-out periods that have the potential to introduce bias. Short duration of treatment in some studies may limit the extent to which the interventions were found to be effective. Sustained effectiveness was not assessed except for one study. Conclusions: There is limited and low quality evidence for the effectiveness of rutosides, hidrosmin, and defibrotide to treat PTS. There is also limited and low quality evidence for the effectiveness of GCS, but IPC devices seem to provide at least short term relief from PTS. More rigorous studies are needed to assess the effectiveness and sustainability of pharmacologic and compression treatments for PTS, and study endpoints should focus on clinically important improvements in patient condition. Disclosures: No relevant conflicts of interest to declare.

Pine processionary caterpillar Thaumetopoea pityocampa envenomation in 11 cats: a retrospective study

2017 ◽  
Vol 20 (8) ◽  
pp. 685-689 ◽  
Author(s):  
Céline Pouzot-Nevoret ◽  
Maxime Cambournac ◽  
Amandine Violé ◽  
Isabelle Goy-Thollot ◽  
Gilles Bourdoiseau ◽  
...  
Keyword(s):  
Clinical Signs ◽  
Clinical Manifestations ◽  
Thaumetopoea Pityocampa ◽  
Pine Processionary Moth ◽  
Processionary Moth ◽  
Pine Processionary Caterpillar ◽  
Long Term Follow Up

Objectives The aim of this study was to describe the clinical manifestations in cats of contact with caterpillars of the pine processionary moth. Methods Data were retrospectively obtained from the medical records (2004–2016) of cats that had been in contact with caterpillars of the pine processionary moth. Results Eleven cats were included in the study. The prevalence of lepidopterism was 0.13%. Tongue lesions and ptyalism were both present in 10/11 (91%) cats. Systemic signs consisted exclusively of vomiting and were encountered in 4/11 (36%) cats. The survival rate was 100%. Long-term follow-up data were available for 7/11 cats, and none of the cats showed impaired quality of life or definitive sequelae. Conclusions and relevance The clinical presentation of lepidopterism in cats appears to be similar to that in other animals; however, the clinical signs are less severe than those previously reported, mainly owing to the cautious behaviour of this species. Moreover, the prognosis is excellent, the length of hospitalisation is short (maximum 48 h) and our study showed the absence of any long-term disability after hospital discharge.

Dissolution of cholelithiasis in a Cavalier King Charles Spaniel receiving conservative management with ursodeoxycholic acid

2020 ◽  
Vol 8 (3) ◽  
pp. e001206
Author(s):  
Frederik Allan ◽  
Katie Elizabeth McCallum ◽  
Marie-Aude Genain ◽  
Benjamin John Harris ◽  
Penny J Watson
Keyword(s):  
Veterinary Medicine ◽  
Ursodeoxycholic Acid ◽  
Conservative Management ◽  
Clinical Signs ◽  
Human Medicine ◽  
Complete Dissolution ◽  
Abdominal Ultrasonography ◽  
Cavalier King Charles Spaniel ◽  
Low Fat Diet

A six-year-old female neutered Cavalier King Charles Spaniel presented with recurrent diarrhoea, intermittent vomiting and anorexia. She was diagnosed with partially obstructive cholelithiasis with concurrent suspected chronic pancreatitis based on abdominal ultrasonography and blood biochemistry. The dog responded to conservative management with ursodeoxycholic acid (UDCA), paracetamol and a low-fat diet with resolution of clinical signs attributable to obstructive cholelithiasis and near-complete dissolution of the cholelith at follow-up eight months after presentation. In human medicine, UDCA has been reported to be effective in cholelith dissolution, prevention of cholelith formation and resolution of clinical signs due to cholelithiasis but the non-surgical literature in veterinary medicine is limited. To the authors’ knowledge, this is the first reported case of dissolution of a cholelith in a dog receiving conservative management.

scholarly journals Hyperandrogenism associated with an ovarian remnant in a spayed female cat

2019 ◽  
Vol 5 (2) ◽  
pp. 205511691988569
Author(s):  
Sarah A Jones ◽  
Scott L Owens ◽  
Stephen J Birchard
Keyword(s):  
Elevated Serum ◽  
Clinical Signs ◽  
Exploratory Laparotomy ◽  
Stimulation Test ◽  
Acth Stimulation Test ◽  
Acth Stimulation ◽  
Abdominal Ultrasonography ◽  
History Of ◽  
Hypoechoic Nodule

Case summary An 11-year-old female, reportedly spayed, domestic shorthair cat was examined for a 4-month history of weight loss, aggression, urine spraying, malodorous urine and estrus-like behavior. Physical examination revealed thickened skin, a mildly prominent vulva and confirmed malodorous urine. On abdominal ultrasonography, a 6 mm hypoechoic nodule was found in the left cranial abdomen. An adrenocorticotropic hormone (ACTH) stimulation test with adrenal panel revealed elevated serum concentrations of androstenedione and testosterone pre- and post-cosyntropin stimulation, mildly decreased cortisol pre- and post-cosyntropin stimulation, and decreased resting aldosterone. Exploratory laparotomy was performed and a cystic, nodular mass was found in the region of the left ovary. The mass was surgically removed and submitted for histopathology; results were conclusive for an ovarian remnant with an intact corpus luteum and non-neoplastic parovarian cysts. Previously observed clinical signs resolved within two weeks of ovariectomy. A follow-up ACTH stimulation test with adrenal panel 6 weeks postoperatively revealed normalization of serum androstenedione, testosterone and cortisol concentrations. Four years postoperatively, at the time of writing, the cat remains free of clinical signs. Relevance and novel information We are unaware of any previously reported cases of non-neoplastic ovarian remnants associated with clinically relevant hyperandrogenism. A non-neoplastic ovarian-dependent hyperandrogenism should be included as a differential diagnosis of spayed female cats showing aggression and urine spraying behavior.

scholarly journals Influence of simethicone and fasting on the quality of abdominal ultrasonography in dogs

2021 ◽  
Author(s):  
M Paninarova ◽  
L Stehlik ◽  
P Proks ◽  
I Nyvltova ◽  
M Vignoli
Keyword(s):  
Gastrointestinal Tract ◽  
Oral Administration ◽  
Lymph Nodes ◽  
Adrenal Glands ◽  
Abdominal Cavity ◽  
Abdominal Ultrasonography ◽  
Ultrasonographic Examination ◽  
Abdominal Organs ◽  
Pancreas Body

The presence of a significant quantity of gas in the gastrointestinal tract may hinder a proper ultrasonographic examination of the abdominal organs. The objective of this study was to investigate the influence of simethicone and fasting on the quality of ultrasonographic examinations of the gastrointestinal tract and the small organs in the abdominal cavity. Fourteen clinically healthy dogs were examined repeatedly after four different preparation protocols. The visualisation of the organs was assessed subjectively with a 3-point scoring system. The administration of simethicone is superior in the visualisation of the ileum, the ileocolic junction, the pancreas (body and right lobe), the jejunal lymph nodes, and both adrenal glands when compared to no preparation. The combination of the oral administration of simethicone and fasting is superior in the visualisation of the pylorus, the duodenum, the jejunum, the ileum, the ileocolic junction, the pancreas (body, right and left lobe), the jejunal lymph nodes, and both adrenal glands when compared to no preparation. The conclusion and clinical relevance from this exploratory study suggest that the oral administration of simethicone and fasting before an ultrasonographic examination significantly improve the visualisation of some abdominal organs.

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