scholarly journals Correlation between capillary oxygen saturation and small intestinal wall thickness in the equine colic patient

2017 ◽  
Vol 4 (1) ◽  
pp. e000197
Author(s):  
Elisabeth Mirle ◽  
Anna Wogatzki ◽  
Robert Kunzmann ◽  
Axel M Schoenfelder ◽  
Lutz F Litzke
Keyword(s):  
Oxygen Saturation ◽  
Wall Thickness ◽  
Intestinal Wall ◽  
Small Intestinal ◽  
Equine Colic

scholarly journals Hemodynamic parameters and vessel tortuosity: an investigation with a mesenterial vascular network

2017 ◽  
Vol 1 (4) ◽  
pp. 62-68
Author(s):  
Roberto Annunziata ◽  
Bettina Reglin ◽  
Axel Pries ◽  
Emanuele Trucco
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Oxygen Saturation ◽  
Wall Thickness ◽  
Blood Velocity ◽  
Vascular Network ◽  
Hemodynamic Parameters ◽  
Vessel Tortuosity ◽  
Wall Shear ◽  
Quantitative Definition

Purpose: The effect of hemodynamic parameters on vessel tortuosity remains un-clear. Here we investigate the correlation of tortuosity with a set of hemodynamicparameters in a mesenterial vascular network.Methods: A mesenterial vascular network of 389 vessels (131 arteries, 132 veins, and 126 capillaries) was imaged. Eleven hemodynamic parameters were measured (pressure, wall shear stress, diameter, blood velocity and flow, viscosity, haematocrit, partial oxygen saturation, oxygen saturation, wall thickness, and local vessel density). Tortuosity was assessed quantitatively with a validated algorithm and correlation computed with subsets of hemodynamic parameters selected by a lasso regressor.Results: Results suggest that tortuosity is related to pressure, wall shear stress, diameter, blood velocity, viscosity, partial but not full oxygen saturation, and wall thickness for the arteries; diameter, blood flow, hematocrit, and density for the veins; and viscosity (but not hematocrit), partial and full oxygen saturation, and density for the capillaries. The combination of hemodynamic parameters correlating best with tortuosity is the set of all parameters except density (r = 0.64, p < 0.01), using as tortuosity definition the set of tortuosity features (geometric measures) correlating best with a single hemodynamic factor for the arteries.Conclusion: This pilot suggests two general conclusions. First, the quantitative definition of tortuosity (i.e., the set of geometric features adopted) should be tuned to the specific data and problem considered. Second, tortuosity is caused by a combination of hemodynamic factors, not a single one.

scholarly journals Enteropathy associated T-cell lymphoma

2007 ◽  
Vol 135 (1-2) ◽  
pp. 80-84
Author(s):  
Milena Bakrac ◽  
Branka Bonaci-Nikolic ◽  
Natasa Colovic ◽  
Sanja Simic-Ogrizovic ◽  
Miodrag Krstic ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
Previous History ◽  
Lymph Node Biopsy ◽  
Intestinal Wall ◽  
T Cell Lymphoma ◽  
The Third ◽  
History Of ◽  
Small Intestinal ◽  
Mesenterial Lymph Node

Enteropathy associated T-cell lymphoma (EATCL) is a high grade, pleomorphic peripheral T-cell lymphoma with usually cytotoxic phenotype. This is a case report of three patients with EATCL. The first patient was 50 year-old woman with four year history of gluten sensitive enteropathy (GSE). Diagnosis of lymphoma was confirmed after the resection of the jejunum (small intestine obstruction). Pathohistological (PAS, Reticulin, Giemsa) and immunohistochemical (anti-LCA, anti-CD20, anti- CD45RO, anti-CD3) methods revealed the diagnosis of EATCL: CD45RO+, CD3+. After the third cycle of chemotherapy, the disease progressed with massive lung infiltration. Patient died due to complications of bone marrow aplasia. The second patient was 23 year-old woman with long earlier history of GSE. She presented with the acute renal failure. According to established diagnosis of tubulointerstitial nephritis, she was treated with pulse doses of steroid therapy. After temporary improvement, she had dissemination of the disease. On MRI, small intestinal wall was thickened, and abdominal lymph nodes were enlarged with extraluminal compression of common bile duct. Laparotomy with mesenterial lymph node biopsy and consecutive pathohistological and immunohistochemical analyses revealed the diagnosis of EATCL. The patient received chemotherapy, but she died with signs of pulmonary embolization. The third patient was 53 year-old woman without previous history of GSE. Diagnosis of EATCL was revealed after the resection of jejunum because of small intestinal obstruction. She received two cycles of chemotherapy, but she died with signs of disease progression. IgA antiendomysial antibodies were detected in the serum of all patients. The overall survival of patients was 7 months. The possibility of lymphoma rising in patients with clinical progression of GSE despite gluten free diet must be kept in mind.

scholarly journals LOCALIZATION OF β-GALACTOSIDASES AND ACID PHOSPHATASE IN THE SMALL INTESTINAL WALL COMPARISON OF ADULT AND SUCKLING RAT

1969 ◽  
Vol 17 (5) ◽  
pp. 341-347 ◽  
Author(s):  
CHRISTER NORDSTRÖM ◽  
OTAKAR KOLDOVSKÝ ◽  
ARNE DAHLQVIST
Keyword(s):  
Acid Phosphatase ◽  
Intestinal Wall ◽  
Quantitative Comparison ◽  
Distribution Profile ◽  
Before And After ◽  
Fresh Frozen ◽  
Old Rats ◽  
Small Intestinal ◽  
Different Parts ◽  
Flat Distribution

By horizontal sectioning of fresh frozen pieces of rat intestinal wall different parts of the villi and crypts were isolated. The sections were collected in groups, homogenized and used for enzyme analyses. Single sections for histologic examination were taken before and after each collection. A quantitative comparison of the distribution of the two intestinal β-galactosidases, EC 3.2.1.23 (neutral and acid β-galactosidase), and the acid phosphatase, EC 3.1.3.2, in jejunum and ileum of adult and suckling (12 days old) rats was performed. The neutral β-galactosidase, which corresponds to the enzyme usually called lactase, was always present along the villi with the highest activities in the apical halves of the villi. This distribution profile is typical for digestion enzymes. The acid β-galactosidase, which is chiefly a heterogalactosidase, and acid phosphatase were found to have a rather flat distribution profile with about the same activities along the villi and in the crypts. The only exception was the ileum of suckling rat, in which especially the acid β-galactosidase showed higher activity in the villi and decreased toward the crypts. The results support the concept that the neutral β-galactosidase is responsible for the digestion of dietary lactose, while the acid β-galactosidase seems to have a different functional significance. That this enzyme is distributed in parallel with the acid phosphatase is consistent with the suggestion that the acid β-galactosidase may be a lysosomal enzyme.

scholarly journals Meconium contaminated amniotic fluid leads to intestinal wall thickness and affects the functional outcome of abdominal wall defects

2019 ◽  
Author(s):  
Melanie Kapapa ◽  
Teresa Rieg ◽  
Alexandre Serra
Keyword(s):  
Mechanical Ventilation ◽  
Parenteral Nutrition ◽  
Amniotic Fluid ◽  
Hospital Stay ◽  
Functional Outcome ◽  
Abdominal Wall ◽  
Wall Thickness ◽  
Intestinal Wall ◽  
Oral Feeding ◽  
Abdominal Wall Defects

Abstract Background: We analysed abdominal wall defect patients over an 11-year period, aiming to assess the influence of meconium-contaminated amniotic fluid . Meconium-contaminated amniotic fluid leading to intestinal wall thickness and impairs surgical and functional outcome. Methods: A retro- and prospective, observational case- control design was used to compare gastroschisis (n=36) and omphalocele (n=18) children. Physical data, color of amniotic fluid, pre- and perinatal problems, operative complications and surgical technique, postoperative complications, duration of ICU stay, mechanical ventilation, parenteral nutrition, begin of oral feeding and total hospital stay were collected. Data was analyzed with descriptive methods, t-test and non-parametric tests such as Wilcoxon and Kruskal-Wallis were performed in addition to ANOVA, including post-hoc testing accepting a confidence interval of 95% (p<0.05) by using IBM SPSS software, version 23 (IBM, Illinois, USA). Results: Rate of meconium-contaminated amniotic fluid is significantly higher in GS compared to OC, delivery problems are also significantly higher, this yields in significantly more bowel loops anomalies and problems during surgery but had no significant influence on primary abdominal wall closures rate. The post-surgical outcome of OC was significantly better compared to GS. Within the GS, those with swollen intestines had significantly longer ICU stays due to extended mechanical ventilation, parenteral nutrition and delayed initiation of oral feeding. Same results were found for secondary closures compared to primary abdominal wall closures in GS group. Conclusions: Worsen functional short-term outcome of GS children was directly addicted to meconium contamination of amniotic fluid due to swollen intestines and because of this more post-surgical problem including significantly extended hospital stay were observed.

scholarly journals Experimental substantiation of using a synthetic peptide in the complex surgical treatment of acute intestinal obstruction

2018 ◽  
pp. 138-140
Author(s):  
А.А. Коваленко ◽  
В.К. Хугаева
Keyword(s):  
Surgical Treatment ◽  
Intestinal Obstruction ◽  
Intestinal Anastomosis ◽  
Intestinal Wall ◽  
Acute Intestinal Obstruction ◽  
Study Objective ◽  
Doppler Flowmetry ◽  
Study Results ◽  
Small Intestinal

Высокая смертность при хирургическом лечении острой кишечной непроходимости (ОКН) определила поиск новых методов сопутствующей терапии. Обнаруженная ранее высокая эффективность опиоидных пептидов в стимулировании лимфотока в микрососудах брыжейки тонкой кишки у крыс, восстановлении нарушенной микроциркуляцию и снижении смертности при ряде заболеваний, определила цель данного исследования: изучить роль фармакологической стимуляции лимфотока в динамике ОКН. В работе использовали методы: биомикроскопия, лазерная допплеровская флоуметрия брыжейки и стенки тонкой кишки крысы, регистрация сократительной активности лимфатических микрососудов ЛМ методом фотометрии, морфометрия микрососудов, видео- и фотосъемка. Полученные результаты предполагают наличие адаптационной роли у активатора микролимфоциркуляции (опиоидного пептида-171 прямого действия) в комплексном хирургическом лечении ОКН. Однократное орошение пептидом межкишечного анастомоза (после удаления) и поврежденного лигатурой фрагмента кишки (перед зашиванием операционной раны) увеличивало выживаемость животных с ОКН на 23%. У всех выживших животных отмечено восстановление: проходимости кишки, микроциркуляции в кровеносных и лимфатических микрососудах, а также структуры стенки кишки. High mortality in the surgical treatment of acute intestinal obstruction (AIO) has warranted the search for new methods of concomitant therapy. Opioid peptides have proved highly effective in stimulating the lymphatic flow in rat small intestinal mesenteric microvessels, restoring the impaired microcirculation, and reducing mortality in many diseases. This had determined this study objective: to investigate the role of lymphatic stimulation in the dynamics of AIO. The study used methods of biomicroscopy, laser Doppler flowmetry, and histological examination of the mesentery and the small intestinal wall in rats; recording the contractile activity of lymphatic microvessels using photometry; microvessel morphometry; video and photography. The study results suggested an adaptive role of the lymphatic microcirculation activator (direct-action opioid-171) in the complex surgical treatment of AIO. A one-time peptide irrigation of the intestinal anastomosis (after removal) and the intestinal injuried by the ligature (before the surgical wound was sutured) increased the survival of animals with AIO by 23%. In all surviving animals, recovery of the intestinal patency, blood and lymphatic microcirculation, and the intestinal wall structure was observed.

scholarly journals Intraoperative Control of Hemoglobin Oxygen Saturation in the Intestinal Wall during Anastomosis Surgery

Photonics ◽  
2021 ◽  
Vol 8 (10) ◽  
pp. 427
Author(s):  
Daniil M. Kustov ◽  
Tatiana A. Savelieva ◽  
Timofey A. Mironov ◽  
Sergey S. Kharnas ◽  
Vladimir V. Levkin ◽  
...  
Keyword(s):  
Oxygen Saturation ◽  
Blood Supply ◽  
Light Attenuation ◽  
Taylor Series Expansion ◽  
Intestinal Wall ◽  
Intestinal Lumen ◽  
Hemoglobin Oxygen Saturation ◽  
Colon Wall ◽  
Hemoglobin Saturation ◽  
Intraoperative Control

During surgery for colon cancer, monitoring of the oxygen saturation of hemoglobin in the tissues under study makes it possible to assess the degree of blood supply to the anastomosis areas of the colon. Adequate blood supply in this area is decisive in terms of the consistency of the anastomosis and can significantly reduce the risk leakage of anastomosis. In this work, we propose a new approach to assessing the hemoglobin oxygen saturation based on measuring both the diffuse reflectance and transmittance spectra of the colon wall tissues. The proposed method is based on the use of two fiber-optic tools for irradiation from both sides—the intestinal lumen and the outside of the intestinal wall. The spectra are recorded from the external side. To determine the degree of hemoglobin saturation, two algorithms, both based on the Taylor series expansion of the coefficient of light attenuation by tissues, are proposed. The results of a clinical study of the proposed approach on volunteers were obtained, allowing to draw a conclusion about the applicability of the approach in a clinical setting.

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