scholarly journals AGE-RELATED MORPHOLOGICAL CHARACTERISTICS OF UNAFFECTED SMALL INTESTINAL WALL IN RATS

2013 ◽  
Vol 12 (1) ◽  
pp. 12-16
Author(s):  
I. Ye. Herasymiuk ◽  
A. V. Miz
Keyword(s):  
Morphological Characteristics ◽  
Intestinal Wall ◽  
Age Related ◽  
Small Intestinal

scholarly journals Enteropathy associated T-cell lymphoma

2007 ◽  
Vol 135 (1-2) ◽  
pp. 80-84
Author(s):  
Milena Bakrac ◽  
Branka Bonaci-Nikolic ◽  
Natasa Colovic ◽  
Sanja Simic-Ogrizovic ◽  
Miodrag Krstic ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
Previous History ◽  
Lymph Node Biopsy ◽  
Intestinal Wall ◽  
T Cell Lymphoma ◽  
The Third ◽  
History Of ◽  
Small Intestinal ◽  
Mesenterial Lymph Node

Enteropathy associated T-cell lymphoma (EATCL) is a high grade, pleomorphic peripheral T-cell lymphoma with usually cytotoxic phenotype. This is a case report of three patients with EATCL. The first patient was 50 year-old woman with four year history of gluten sensitive enteropathy (GSE). Diagnosis of lymphoma was confirmed after the resection of the jejunum (small intestine obstruction). Pathohistological (PAS, Reticulin, Giemsa) and immunohistochemical (anti-LCA, anti-CD20, anti- CD45RO, anti-CD3) methods revealed the diagnosis of EATCL: CD45RO+, CD3+. After the third cycle of chemotherapy, the disease progressed with massive lung infiltration. Patient died due to complications of bone marrow aplasia. The second patient was 23 year-old woman with long earlier history of GSE. She presented with the acute renal failure. According to established diagnosis of tubulointerstitial nephritis, she was treated with pulse doses of steroid therapy. After temporary improvement, she had dissemination of the disease. On MRI, small intestinal wall was thickened, and abdominal lymph nodes were enlarged with extraluminal compression of common bile duct. Laparotomy with mesenterial lymph node biopsy and consecutive pathohistological and immunohistochemical analyses revealed the diagnosis of EATCL. The patient received chemotherapy, but she died with signs of pulmonary embolization. The third patient was 53 year-old woman without previous history of GSE. Diagnosis of EATCL was revealed after the resection of jejunum because of small intestinal obstruction. She received two cycles of chemotherapy, but she died with signs of disease progression. IgA antiendomysial antibodies were detected in the serum of all patients. The overall survival of patients was 7 months. The possibility of lymphoma rising in patients with clinical progression of GSE despite gluten free diet must be kept in mind.

Ontogenetic development of monosaccharide and amino acid transporters in rabbit intestine

1990 ◽  
Vol 259 (4) ◽  
pp. G544-G555 ◽  
Author(s):  
R. K. Buddington ◽  
J. M. Diamond
Keyword(s):  
Amino Acids ◽  
Small Intestine ◽  
Metabolic Rate ◽  
Direct Proportion ◽  
Natural Diet ◽  
Sugar Absorption ◽  
Age Related ◽  
Rabbit Intestine ◽  
Small Intestinal ◽  
Rabbit Milk

We measured brush-border uptakes of seven sugars and amino acids by rabbit intestine as a function of age from the day of birth to adulthood. Gut dimensions, especially those of the colon and cecum, increase more rapidly with body weight than would be true if rabbits maintained identical proportions as they grew. However, nominal small intestinal area increases in approximately direct proportion to the animal's basal metabolic rate. For all solutes except fructose, uptake per milligram of intestinal tissue is maximal at or near birth and declines to a level 2.5-5 times lower in the adult. Because of small intestinal growth, though, the total uptake capacity of the whole length of the small intestine increases in approximately direct proportion to metabolic rate. Fructose uptake per milligram is unique in increasing steeply at the time of weaning, correlated with the post-weaning first appearance of fructose in the natural diet. Age-related changes in uptake ratios among aldohexoses or amino acids suggest developmental sequences of related transporters. Correlated with the very high protein content of rabbit milk, the proline-to-glucose uptake ratio is higher in suckling rabbits than in other sucking mammals. Remarkably, the ratio for adult rabbits is higher than in other monogastric herbivores and is instead similar to values for carnivores. In explanation, although the transport capacity of the small intestine appears to account for proline absorption in rabbits of all ages and for sugar absorption in suckling rabbits, the hindgut may be a major site of carbohydrate digestion in adult rabbits.

scholarly journals LOCALIZATION OF β-GALACTOSIDASES AND ACID PHOSPHATASE IN THE SMALL INTESTINAL WALL COMPARISON OF ADULT AND SUCKLING RAT

1969 ◽  
Vol 17 (5) ◽  
pp. 341-347 ◽  
Author(s):  
CHRISTER NORDSTRÖM ◽  
OTAKAR KOLDOVSKÝ ◽  
ARNE DAHLQVIST
Keyword(s):  
Acid Phosphatase ◽  
Intestinal Wall ◽  
Quantitative Comparison ◽  
Distribution Profile ◽  
Before And After ◽  
Fresh Frozen ◽  
Old Rats ◽  
Small Intestinal ◽  
Different Parts ◽  
Flat Distribution

By horizontal sectioning of fresh frozen pieces of rat intestinal wall different parts of the villi and crypts were isolated. The sections were collected in groups, homogenized and used for enzyme analyses. Single sections for histologic examination were taken before and after each collection. A quantitative comparison of the distribution of the two intestinal β-galactosidases, EC 3.2.1.23 (neutral and acid β-galactosidase), and the acid phosphatase, EC 3.1.3.2, in jejunum and ileum of adult and suckling (12 days old) rats was performed. The neutral β-galactosidase, which corresponds to the enzyme usually called lactase, was always present along the villi with the highest activities in the apical halves of the villi. This distribution profile is typical for digestion enzymes. The acid β-galactosidase, which is chiefly a heterogalactosidase, and acid phosphatase were found to have a rather flat distribution profile with about the same activities along the villi and in the crypts. The only exception was the ileum of suckling rat, in which especially the acid β-galactosidase showed higher activity in the villi and decreased toward the crypts. The results support the concept that the neutral β-galactosidase is responsible for the digestion of dietary lactose, while the acid β-galactosidase seems to have a different functional significance. That this enzyme is distributed in parallel with the acid phosphatase is consistent with the suggestion that the acid β-galactosidase may be a lysosomal enzyme.

scholarly journals Correlation between capillary oxygen saturation and small intestinal wall thickness in the equine colic patient

2017 ◽  
Vol 4 (1) ◽  
pp. e000197
Author(s):  
Elisabeth Mirle ◽  
Anna Wogatzki ◽  
Robert Kunzmann ◽  
Axel M Schoenfelder ◽  
Lutz F Litzke
Keyword(s):  
Oxygen Saturation ◽  
Wall Thickness ◽  
Intestinal Wall ◽  
Small Intestinal ◽  
Equine Colic

scholarly journals Experimental substantiation of using a synthetic peptide in the complex surgical treatment of acute intestinal obstruction

2018 ◽  
pp. 138-140
Author(s):  
А.А. Коваленко ◽  
В.К. Хугаева
Keyword(s):  
Surgical Treatment ◽  
Intestinal Obstruction ◽  
Intestinal Anastomosis ◽  
Intestinal Wall ◽  
Acute Intestinal Obstruction ◽  
Study Objective ◽  
Doppler Flowmetry ◽  
Study Results ◽  
Small Intestinal

Высокая смертность при хирургическом лечении острой кишечной непроходимости (ОКН) определила поиск новых методов сопутствующей терапии. Обнаруженная ранее высокая эффективность опиоидных пептидов в стимулировании лимфотока в микрососудах брыжейки тонкой кишки у крыс, восстановлении нарушенной микроциркуляцию и снижении смертности при ряде заболеваний, определила цель данного исследования: изучить роль фармакологической стимуляции лимфотока в динамике ОКН. В работе использовали методы: биомикроскопия, лазерная допплеровская флоуметрия брыжейки и стенки тонкой кишки крысы, регистрация сократительной активности лимфатических микрососудов ЛМ методом фотометрии, морфометрия микрососудов, видео- и фотосъемка. Полученные результаты предполагают наличие адаптационной роли у активатора микролимфоциркуляции (опиоидного пептида-171 прямого действия) в комплексном хирургическом лечении ОКН. Однократное орошение пептидом межкишечного анастомоза (после удаления) и поврежденного лигатурой фрагмента кишки (перед зашиванием операционной раны) увеличивало выживаемость животных с ОКН на 23%. У всех выживших животных отмечено восстановление: проходимости кишки, микроциркуляции в кровеносных и лимфатических микрососудах, а также структуры стенки кишки. High mortality in the surgical treatment of acute intestinal obstruction (AIO) has warranted the search for new methods of concomitant therapy. Opioid peptides have proved highly effective in stimulating the lymphatic flow in rat small intestinal mesenteric microvessels, restoring the impaired microcirculation, and reducing mortality in many diseases. This had determined this study objective: to investigate the role of lymphatic stimulation in the dynamics of AIO. The study used methods of biomicroscopy, laser Doppler flowmetry, and histological examination of the mesentery and the small intestinal wall in rats; recording the contractile activity of lymphatic microvessels using photometry; microvessel morphometry; video and photography. The study results suggested an adaptive role of the lymphatic microcirculation activator (direct-action opioid-171) in the complex surgical treatment of AIO. A one-time peptide irrigation of the intestinal anastomosis (after removal) and the intestinal injuried by the ligature (before the surgical wound was sutured) increased the survival of animals with AIO by 23%. In all surviving animals, recovery of the intestinal patency, blood and lymphatic microcirculation, and the intestinal wall structure was observed.

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