Effect of exercise-heat acclimation on cardiac autonomic modulation in Type 2 Diabetes: a pilot study

2020 ◽  
Author(s):  
Michael J. Macartney ◽  
Sean R. Notley ◽  
Christophe Herry ◽  
Ronald J Sigal ◽  
Pierre Boulay ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Heart Rate ◽  
Heat Acclimation ◽  
Cardiac Risk ◽  
Autonomic Modulation ◽  
Older Individuals ◽  
Cardiac Autonomic Modulation ◽  
Before And After ◽  
Bullet Point

The effects of exercise-heat acclimation (HA), in individuals with type 2 diabetes (T2D), on heart rate variability (HRV) remains unclear. We assessed electrocardiogram recordings during exercise-heat stress, in middle-aged-to-older individuals (50-70 years) with (n=6) and without (n=8; CON) T2D, before and after 7-days exercise HA. Exercising heart rate was reduced (CON, -9 ±5 bpm; T2D, -14 ±9 bpm) yet HRV was unresponsive. Given the negative correlations between diminished HRV and cardiac risk, further research is warranted. <b>Novelty bullet point:</b> Our observations indicate that exercise-heat acclimation may not effectively attenuate the deviation toward reduced overall HRV and unfavourable cardiac autonomic modulation in individuals with T2D.

scholarly journals High Fasting Glycemia Predicts Impairment of Cardiac Autonomic Control in Adults With Type 2 Diabetes: A Case-Control Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Lucas Raphael Bento Silva ◽  
Paulo Gentil ◽  
Camila Simões Seguro ◽  
Gabriela Teles de Oliveira ◽  
Maria Sebastiana Silva ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Heart Rate ◽  
Physical Exercise ◽  
Case Control ◽  
Control Group ◽  
Autonomic Modulation ◽  
Cardiac Autonomic Modulation ◽  
Fasting Glycemia ◽  
Chronic Hyperglycemia

IntroductionType 2 diabetes (T2D) is characterized by a metabolic disorder that elevates blood glucose concentration. Chronic hyperglycemia has been associated with several complications in patients with T2D, one of which is cardiac autonomic dysfunction that can be assessed from heart rate variability (HRV) and heart rate recovery (HRR) response, both associated with many aspects of health and fitness, including severe cardiovascular outcomes.ObjectiveTo evaluate the effects of T2D on cardiac autonomic modulation by means of HRV and HRR measurements.Materials and MethodsThis study has an observational with case-control characteristic and involved ninety-three middle-aged adults stratified into two groups (control group - CG, n = 34; diabetes group - DG, n = 59). After signing the free and informed consent form, the patients were submitted to the evaluation protocols, performed biochemical tests to confirm the diagnosis of T2D, collection of R-R intervals for HRV analysis and cardiopulmonary effort test to quantify HRR.ResultsAt rest, the DG showed a reduction in global HRV (SDNN= 19.31 ± 11.72 vs CG 43.09 ± 12.74, p &lt; 0.0001), lower parasympathetic modulation (RMSSD= 20.49 ± 14.68 vs 52.41 ± 19.50, PNN50 = 4.76 ± 10.53 vs 31.24 ± 19.24, 2VD%= 19.97 ± 10.30 vs 28.81 ± 9.77, p &lt; 0.0001 for both indices) and higher HRrest when compared to CG. After interruption of physical exercise, a slowed heart rate response was observed in the DG when compared to the CG. Finally, a simple linear regression showed that fasting glycemia was able to predict cardiac autonomic involvement in volunteers with T2D.ConclusionPatients with T2D presented lower parasympathetic modulation at rest and slowed HRR after physical exercise, which may be associated with higher cardiovascular risks. The findings show the glycemic profile as an important predictor of impaired cardiac autonomic modulation.

scholarly journals Glycemic Variability Is Associated With Reduced Cardiac Autonomic Modulation in Women With Type 2 Diabetes

Diabetes Care ◽  
2015 ◽  
pp. dc140654 ◽  
Author(s):  
Jesper Fleischer ◽  
Simon Lebech Cichosz ◽  
Pernille Hoeyem ◽  
Esben Laugesen ◽  
Per Loegstrup Poulsen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glycemic Variability ◽  
Autonomic Modulation ◽  
Cardiac Autonomic Modulation

scholarly journals The Development of Selected Cardiovascular Parameters in Patients With Type 2 Diabetes Mellitus During a Spa Treatment

2015 ◽  
pp. S661-S667 ◽  
Author(s):  
E. FIALOVÁ ◽  
O. KITTNAR
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Sympathetic Tone ◽  
Control Group ◽  
Electrical Stability ◽  
Before And After ◽  
Spa Treatment

Diabetes mellitus is not just a simple metabolic disorder, however, it is considered to be a cardiovascular disease of a metabolic origin. This is apparent especially when speaking about type 2 diabetes (DM II). The objective of our study was to determine whether a comprehensive spa treatment (procedures and drinking cure) may affect the level of the sympathetic tone of patients suffering from DM II. As an indicator of the sympathetic tone, selected electrocardiographic parameters derived from the heart rate variability and microwave alternans were chosen. There were 96 patients enrolled in our study: 38 patients with poorly controlled DM II and two control groups: 9 patients with compensated DM II and 49 patients, average age without diabetes or other disorders of the glucose metabolism. All received an identical spa treatment and continued their medical therapy. The electrophysiological examination of patients was performed before and after a three-week spa treatment using the KARDiVAR system. Parameters derived from the analysis of heart rate variability (HRV), microvolt T-wave alternans, and microvolt R-wave alternans were analyzed in order to evaluate the tones of the autonomic nervous system (ANS). The control group showed a slight increase of parameter the index of activity of regulatory systems (IRSA) (4.4±1.3 vs. 3.8±1.4; p=0.006) after the spa treatment, while increased heart rate (80.9±11.0 vs. 74.6±9.6; p=0.028), reduced index of centralization (IC) (1.3±0.6 vs. 2.9±1.4; p=0.027) and reduced index of myocardium (IM) (9.9±7.4 vs. 18.0±6.3; p=0.041) were found in patients with a compensated DM II. Patients with a poorly compensated DM II showed a decreased IM (10.9±8.6 vs. 16.9±5.2; p=0.001) and also a reduced IRSA (4.1±3.5 vs. 6.3±1.9; p=0.001). The results proved favorable changes in ANS cardiovascular control of patients with DM II after a spa treatment, especially in terms of reducing the sympathoadrenal system activity (decreased IRSA), improving electrical stability of the myocardium and increasing centrally controlled heart rate variability without overloading the cardiovascular system (drop of IM).

scholarly journals Poor glycemic control impacts linear and non-linear dynamics of heart rate in DM type 2

2015 ◽  
Vol 21 (4) ◽  
pp. 313-317 ◽  
Author(s):  
Daniela Bassi ◽  
Vivian Maria Arakelian ◽  
Renata Gonçalves Mendes ◽  
Flávia Cristina Rossi Caruso ◽  
José Carlos Bonjorno Júnior ◽  
...  
Keyword(s):  
Heart Rate ◽  
Glycemic Control ◽  
Autonomic Neuropathy ◽  
Fasting Glucose ◽  
Poor Glycemic Control ◽  
Cardiovascular Autonomic Neuropathy ◽  
Autonomic Modulation ◽  
Cardiac Autonomic Modulation ◽  
Non Linear

INTRODUCTION: It is well known that type 2 diabetes mellitus (T2DM) produces cardiovascular autonomic neuropathy (CAN), which may affect the cardiac autonomic modulation. However, it is unclear whether the lack of glycemic control in T2DM without CAN could impact negatively on cardiac autonomic modulation. Objective: To evaluate the relationship between glycemic control and cardiac autonomic modulation in individuals with T2DM without CAN. Descriptive, prospective and cross sectional study.METHODS: Forty-nine patients with T2DM (51±7 years) were divided into two groups according to glycosylated hemoglobin (HbA1c): G1≤7% and G2>7.0%. Resting heart rate (HR) and RR interval (RRi) were obtained and calculated by linear (Mean iRR; Mean HR; rMSSD; STD RR; LF; HF; LF/HF, TINN and RR Tri,) and non-linear (SD1; SD2; DFα1; DFα2, Shannon entropy; ApEn; SampEn and CD) methods of heart rate variability (HRV). Insulin, HOMA-IR, fasting glucose and HbA1c were obtained by blood tests.RESULTS: G2 (HbA1c≤7%) showed lower values for the mean of iRR; STD RR; RR Tri, TINN, SD2, CD and higher mean HR when compared with G1 (HbA1c > 7%). Additionally, HbA1c correlated negatively with mean RRi (r=0.28, p=0.044); STD RR (r=0.33, p=0.017); RR Tri (r=-0.35, p=0.013), SD2 (r=-0.39, p=0.004) and positively with mean HR (r=0.28, p=0.045). Finally, fasting glucose correlated negatively with STD RR (r=-0.36, p=0.010); RR Tri (r=-0.36, p=0.010); TINN (r=-0.33, p=0.019) and SD2 (r=-0.42, p=0.002).CONCLUSION: We concluded that poor glycemic control is related to cardiac autonomic modulation indices in individuals with T2DM even if they do not present cardiovascular autonomic neuropathy.

scholarly journals Impact of arterial hypertension and type 2 diabetes on cardiac autonomic modulation in obese individuals with recommendation for bariatric surgery

2019 ◽  
Vol Volume 12 ◽  
pp. 1503-1511 ◽  
Author(s):  
Nara Nóbrega Crispim Carvalho ◽  
Francisco Antônio de Oliveira Junior ◽  
Gitana da Silva ◽  
Vinícius José Baccin Martins ◽  
Valdir de Andrade Braga ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Bariatric Surgery ◽  
Arterial Hypertension ◽  
Autonomic Modulation ◽  
Cardiac Autonomic Modulation

scholarly journals Aquatic exercise and cardiac autonomic modulation of postmenopausal women with type 2 diabetes

2020 ◽  
Vol 19 (2) ◽  
pp. 82
Author(s):  
Eduardo Federighi Baisi Chagas ◽  
Angélica Cristiane Cruz ◽  
Pedro Henrique Rodrigues ◽  
Cristiano Sales Silva ◽  
Robison José Quitério
Keyword(s):  
Type 2 Diabetes ◽  
Postmenopausal Women ◽  
Exercise Program ◽  
Exercise Group ◽  
Aquatic Exercise ◽  
Control Group ◽  
Autonomic Modulation ◽  
Cardiac Autonomic Modulation ◽  
And Control

Objective: Investigating the effect of 12 weeks of an aquatic exercise program on cardiac autonomic modulation by heart rate variability index of postmenopausal women with type 2 diabetes mellitus (T2DM). Methods: A randomized clinical trial was performed in 25 women aged 51 to 83 years, divided into exercise group (EG) (n = 13) submitted for 12 weeks to two weekly sessions of 50 minutes each, and control group (CG) (n = 12) without exercise. Results: Regarding cardiac autonomic modulation significant interaction was observed for TINN values (ms), indicating a slight increase in EG, but mostly a reduction in CG. The regression analysis also pointed effect of aquatic exercise on reducing the LF/HF ratio, after controlling for covariates diastolic blood pressure and dyslipidemia. Conclusion: The aquatic exercise had a significant effect on the reduction of cardiovascular risk, mainly in relation to glycemia and abdominal obesity, which may represent a protective effect of exercise in the progression of autonomic dysfunction, but its effect on autonomic modulation seems to depend on a greater volume and time with aquatic exercise.Keywords: diabetes, women, menopause, autonomic nervous system.

scholarly journals Erratum. Glycemic Variability Is Associated With Reduced Cardiac Autonomic Modulation in Women With Type 2 Diabetes. Diabetes Care 2015;38:682–688

Diabetes Care ◽  
2015 ◽  
Vol 38 (11) ◽  
pp. 2188-2188 ◽  
Author(s):  
Jesper Fleischer ◽  
Simon Lebech Cichosz ◽  
Pernille Hoeyem ◽  
Esben Laugesen ◽  
Per Loegstrup Poulsen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetes Care ◽  
Glycemic Variability ◽  
Autonomic Modulation ◽  
Cardiac Autonomic Modulation
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