Acute Interleukin-6 Administration Impairs Athletic Performance in Healthy, Trained Male Runners

2004 ◽  
Vol 29 (4) ◽  
pp. 411-418 ◽  
Author(s):  
Paula J. Robson-Ansley ◽  
Liesl de Milander ◽  
Malcolm Collins ◽  
Timothy D. Noakes
Keyword(s):  
Interleukin 6 ◽  
Athletic Performance ◽  
Time Trial ◽  
Chronic Fatigue ◽  
Healthy Humans ◽  
Exercise Challenge ◽  
Fatigue Exercise ◽  
Placebo Trial ◽  
Exercise Fatigue ◽  
Receptor Antibodies

Fatigue is an inevitable consequence of physical activity; yet its biological cause remains uncertain. During exercise, a polypeptide messenger molecule interleukin-6 (IL-6) is actively produced. Previously, the administration of recombinant IL-6 (rhIL-6) induced a heightened sensation of fatigue in healthy humans at rest. In contrast, anti-IL-6 receptor antibodies reduced the symptoms of chronic fatigue. In the present study, athletic performance during an exercise challenge consisting of a 10-km running time trial was significantly impaired in trained male runners following the administration of a low dose of rhIL-6 compared to the placebo trial. Key words: prolonged exercise, fatigue, exercise challenge

scholarly journals Ice Water Immersion as an Additional Method in Physiology Recovery in the Sport

2018 ◽  
Vol 1 (3) ◽  
pp. 15-22
Author(s):  
Jair Burboa ◽  
Felipe Godoy ◽  
María Soledad Riquelme ◽  
Eugenia Vivar ◽  
Maximiliano Barahona ◽  
...  
Keyword(s):  
Athletic Performance ◽  
Functional Performance ◽  
Water Immersion ◽  
Chronic Fatigue ◽  
Leg Pain ◽  
Control Group ◽  
Average Height ◽  
Active Recovery ◽  
Jump Test ◽  
Experimental Group

Objective: Soccer has a reduced overall recovery time. If these situations are not properly controlled they can cause the athlete chronic fatigue, an increase in delayed-onset muscle soreness (DOMS) and thus result in a decrease in athletic performance. There are several therapies that have attempted to improve athletic performance, decrease the percentage of injuries and results in soccer. Training and recovery instances are opportunities to find ways to address this issue. Understanding the physiology of recovery is essential to accelerate some processes, with the aim of shortening the times. Subjects: Cryotherapy could improve functional performance tests and decrease pain in soccer players. Our work design is an experimental prospective study. Method: Twenty subjects (10 experimental subjects and 10 control group subjects), between the ages of 17 and 23, who are members of a university men's soccer team, participated in the study. The following variables were controlled: power; the number of jumps, the average height of a jump in a 30-second continuous jump test, and DOMS perception through visual analog scale (VAS). Both groups shall be subjected to a more active recovery as well as elongation carried out by the coaching staff. In addition to this, the experimental group shall also be subjected to ice baths (42-47 °F) for three minutes. Results: We found significant statistical differences in the number of jumps and the power of the same in the control group, thus obtaining improvements. No significant differences were observed in either group for the average jump height and percentage yield variables. In the assessment of DOMS significant differences were observed, with a lower perception of DOMS seen in the experimental group. Conclusion: Ice baths provide favorable results in some aspects of the 30-second continuous jump test, decreasing the perception of leg pain and fatigue, and therefore they can be considered a valid alternative in the management of these athletes.

scholarly journals Causes of extreme fatigue in underperforming athletes - a synthesis of recent hypotheses and reviews

2006 ◽  
Vol 18 (4) ◽  
pp. 108 ◽  
Author(s):  
PJ Robson-Ansley ◽  
L Lakier Smith
Keyword(s):  
Chronic Fatigue Syndrome ◽  
South African ◽  
Athletic Performance ◽  
Sports Medicine ◽  
Chronic Fatigue ◽  
Cytokine Release ◽  
South African Journal ◽  
Fatigue Syndrome ◽  
Inflammatory State ◽  
African Journal

The underperformance syndrome (UPS), previously known as the overtraining syndrome (OTS), has been defined as a persistent decrement in athletic performance capacity despite 2 weeks of relative rest. Clinical research has suggested that cytokines play a key role in fatigue in disease and chronic fatigue syndrome. Furthermore, it has recently been demonstrated that exogenous administration of interleukin-6 (IL-6) increases the sensation of fatigue during exercise. In light of current cytokine and chronic fatigue syndrome research, this article reviews and updates the cytokine theories that attempt to explain the aetiology of the debilitating fatigue experienced in OTS/UPS. Initially, it was proposed that UPS may be caused by excessive cytokine release during and following exercise, causing a chronic inflammatory state and ‘cytokine sickness'. More recently, the hypothesis was extended and it was proposed that time-dependent sensitisation could provide a model through which the aetiology of UPS may be explained. According to this model, the principal abnormal factor in UPS is an intolerance/heightened sensitivity to IL-6 during exercise. South African Journal of Sports Medicine Vol. 18 (4) 2006: pp. 108-114

Using an interleukin-6 challenge to evaluate neuropsychological performance in chronic fatigue syndrome

2002 ◽  
Vol 32 (6) ◽  
pp. 1075-1089 ◽  
Author(s):  
M. C. ARNOLD ◽  
D. A. PAPANICOLAOU ◽  
J. A. O'GRADY ◽  
A. LOTSIKAS ◽  
J. K. DALE ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Interleukin 6 ◽  
Psychological Functioning ◽  
Short Term Memory ◽  
Somatic Symptoms ◽  
Chronic Fatigue ◽  
Cognitive Measures ◽  
Attention And Executive Control ◽  
Fatigue Syndrome ◽  
Normal Controls

Background. Individuals with acute infections experience a range of symptoms including fatigue, malaise, muscle aches, and difficulties with concentration and memory that are usually self-limited. This cluster of symptoms is otherwise, similar to those that characterize chronic fatigue syndrome (CFS). The goal of the present study was to evaluate the cognitive and psychological functioning of CFS patients and normal controls (NCs) when they both were experiencing acute influenza-like symptoms. To induce influenza-like symptoms, we administered interleukin-6 (IL-6), a cytokine that temporarily activates the acute phase immunological and endocrine responses.Methods. Nineteen patients who met the 1994 International CFS Study Group Criteria and ten normal controls (NCs) completed routine clinical evaluations, neuropsychological tests of short-term memory, selective attention, and executive control, and self-ratings of somatic symptoms and psychological mood before, shortly following, and 1 day after IL-6 administration.Results. CFS patients consistently reported more somatic symptoms, even when both groups perceived that they were ill. Both groups somatic symptoms increased during the IL-6 challenge, but the CFS patients symptoms increased more rapidly than controls. In general, the CFS patients performed similarly to NCs on the cognitive measures before, during, and after the IL-6. In contrast to predictions, IL-6 provocation did not impair the cognitive performance of either CFS patients or NCs.Conclusions. The IL-6 provocation exacerbated the patients self-reported symptoms but did not reveal notable cognitive impairments between patients and controls during cytokine-induced acute influenza-like symptoms.

Study on Efficient Central Fatigue Detection Scheme

2013 ◽  
Vol 312 ◽  
pp. 615-619
Author(s):  
Yi Xiong ◽  
Wen Tao Su
Keyword(s):  
Athletic Performance ◽  
Research Work ◽  
Central Fatigue ◽  
Focus Of Attention ◽  
Training Load ◽  
Generation Mechanism ◽  
Detection Scheme ◽  
Exercise Fatigue ◽  
Fatigue Detection ◽  
Fatigue Recovery

The growing sports training load and the more prone to fatigue will directly affect the athletes fatigue recovery, and improvement of athletic performance, so the research of the generation mechanism of fatigue and effective way to eliminate fatigue is increasingly important. Scientists gradually put the fatigue prevention and recovery promotion on a day-to-day research work. As a kind of exercise fatigue, central fatigue during exercise has increasingly become the focus of attention. This paper mainly explains the central fatigue mechanisms and detection.

scholarly journals Changes in Gut and Plasma Microbiome following Exercise Challenge in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

PLoS ONE ◽  
2015 ◽  
Vol 10 (12) ◽  
pp. e0145453 ◽  
Author(s):  
Sanjay K. Shukla ◽  
Dane Cook ◽  
Jacob Meyer ◽  
Suzanne D. Vernon ◽  
Thao Le ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Fatigue Syndrome ◽  
Exercise Challenge

Experimental Study on Biomedical Signal Acquisition of Sports Fatigue

2020 ◽  
Vol 10 (4) ◽  
pp. 884-889
Author(s):  
Mingli Chi
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Maximal Exercise ◽  
Processing System ◽  
Future Application ◽  
Signal Acquisition ◽  
Biomedical Signal ◽  
Fatigue Exercise ◽  
Exercise Induced ◽  
Exercise Fatigue

To explore the biomedical signal acquisition of sports fatigue, the Pclab-UE biomedical signal acquisition and processing system is used to collect and process heart rate variability (HRV) automatically after quiet and fatigue exercise. In the meanwhile, the experimental data are analyzed. The heart rate variability of the subjects is recorded, aiming to provide experimental evidence for the future application of HRV in the diagnosis of exercise fatigue. Moreover, it also provides a noninvasive diagnostic index for exercise fatigue and exercise training practice. The research results showed that, the HRV values in the sub-maximal exercise caused fatigue. The maximal exercise induced fatigue is significantly decreased and there are significant differences. As a result, it is summed up that we can use HRV as a quantitative analysis index for the diagnosis of sports fatigue.

SAT0076 Comparison of anti-interleukin-6 and anti-interleukin-6 receptor antibodies using in vivo functional systems

2013 ◽  
Vol 71 (Suppl 3) ◽  
pp. 495.3-495
Author(s):  
S. Shaw ◽  
D. Marshall ◽  
H. Neale ◽  
K. Kretsos ◽  
T. Bourne ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Functional Systems ◽  
Interleukin 6 Receptor ◽  
Receptor Antibodies
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