Norcantharidin analogues — Synthesis and evaluation of growth inhibition in a panel of selected tumor-cell lines

2007 ◽  
Vol 85 (11) ◽  
pp. 938-944 ◽  
Author(s):  
Liping Deng ◽  
Li Shen ◽  
Jing Zhang ◽  
Bo Yang ◽  
Qiaojun He ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Growth Inhibition ◽  
Cell Lines ◽  
Antiproliferative Activity ◽  
Aromatic Amines ◽  
Cycloaddition Reaction ◽  
Dipolar Cycloaddition ◽  
Tumor Cell Lines ◽  
Derivatives Of

A series of norcantharidin (NCTD) analogues have been synthesized by [3+2]1,3-dipolar cycloaddition reaction of norcantharidin derivatives of substituted aromatic amines with four nitrile oximes. All analogues have been screened for their antiproliferative activity in vitro against a panel of tumor cell lines: KB, SGC-7901, HL60, Bel-7402, HO-8910, and ECA109, producing IC50 values from 0.36 µmol/L to >100 µmol/L. Compound 9d showed potency for the treatment of hepatoma, with IC50 value to Bel-7402 cell line comparable to that of norcantharidin.Key words: norcantharidin analogues, isoxazoline, growth inhibition.

Synthesis and biological evaluation of novel derivatives of gambogenic acid as anticancer agents

MedChemComm ◽  
2015 ◽  
Vol 6 (2) ◽  
pp. 334-338 ◽  
Author(s):  
Peng Huang ◽  
Zhong Hu ◽  
Liqin He ◽  
Xiaoshan Wang ◽  
Yaxian Wu
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Anticancer Agents ◽  
Antiproliferative Activity ◽  
Biological Evaluation ◽  
Tumor Cell Lines ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of

A series of novel derivatives of gambogenic acid (GNA) were synthesized and evaluated for their in vitro antiproliferative activity against four kinds of tumor cell lines. These compounds displayed potent antiproliferative activity. In particular, compound 3f exhibited superior antiproliferative activity against these tumor cell lines than GNA.

scholarly journals Antiproliferative Activity of Cucurbitaceae Species Extracts from Southeast of Mexico

2019 ◽  
Author(s):  
Karen Morales-Vela ◽  
Flor Celeste Pérez-Sánchez ◽  
Jose M. Padron ◽  
Olivia Márquez-Fernández
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Antiproliferative Activity ◽  
Human Tumor ◽  
Tumor Cell Lines ◽  
Human Tumor Cell Lines ◽  
Organic Extracts ◽  
Different Types ◽  
A549 Lung

There are many species of endemic plants from Mexico, without food or commercial use, but with different applications in traditional medicine and valuable for their content of secondary metabolites. In this sense, we found two species of Cucurbitacea family plants natives of southeast and gulf of México, with traditionally use how soap and laundry agent, control of some pests, and it has also been used how infusion for the treatment of different types of dermatitis and stomachache. In the present work, we evaluate the antiproliferative activity in vitro, of six crude organic extracts, tested against six human tumor cell lines, A549 (lung), HBL-100 (breast), HeLa (cervix), SW1573 (lung), T-47D (breast) and WiDr (colon), the results indicated that at least three extracts from both species presents an interesting antiproliferative activity on five tumor cell lines.

In Vitro Antiproliferative Activity of Petiveria Alliacea L. on Several Tumor Cell Lines

1993 ◽  
Vol 27 ◽  
pp. 105-106 ◽  
Author(s):  
L. Jovicevic ◽  
M.P. Troiani ◽  
A.Capezzone de Joannon ◽  
L. Saso ◽  
G. Mezzanti ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Antiproliferative Activity ◽  
Tumor Cell Lines ◽  
Petiveria Alliacea

scholarly journals Cytotoxicity screening of Thymus vulgaris L. essential oil in brine shrimp nauplii and cancer cell lines

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Haris Niksic ◽  
Fahir Becic ◽  
Emina Koric ◽  
Irma Gusic ◽  
Elma Omeragic ◽  
...  
Keyword(s):  
Essential Oil ◽  
Tumor Cell ◽  
Cell Lines ◽  
Antiproliferative Activity ◽  
Brine Shrimp ◽  
Thymus Vulgaris ◽  
Tumor Cell Lines ◽  
Brine Shrimp Lethality ◽  
Dose Dependent

AbstractAmong natural products, essential oils from aromatic plants have been reported to possess potent anticancer properties. In this work, we aimed to perform the cytotoxic concentration range screening and antiproliferative activity screening of chemically characterized Thymus vulgaris L. essential oil. In vivo bioassay was conducted using the brine shrimp lethality test (BSLT). In vitro evaluation of antiproliferative activity was carried out on three human tumor cell lines: breast adenocarcinoma MCF-7, lung carcinoma H460 and acute lymphoblastic leukemia MOLT-4 using MTT assay. Essential oil components thymol (36.7%), p-cymene (30.0%), γ-terpinene (9.0%) and carvacrol (3.6%) were identified by gas chromatography/mass spectrometry. Analyzed essential oil should be considered as toxic/highly toxic with LC50 60.38 µg/mL in BSLT and moderate/weakly cytotoxic with IC50 range 52.65–228.78 µg/mL in vitro, according to evaluated cytotoxic criteria. Essential oil induced a dose-dependent inhibition of cell proliferation in all tested tumor cell lines and showed different sensitivity. Dose dependent toxicity observed in bioassay as well as the in vitro assay confirmed that brine shrimp lethality test is an adequate method for preliminary toxicity testing of Thymus vulgaris L. essential oil in tumor cell lines.

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