On the microwave-assisted synthesis of acylphenothiazine derivatives — Experiment versus theory synergism
Keyword(s):
The microwave-assisted synthesis of a series of acylphenothiazine derivatives is described. 10H-Phenothiazine-3-carbaldehyde derivatives were obtained in moderate yields by the Duff formylation reaction, and 10-acetyl-phenothiazine derivatives were obtained in excellent yields by acetylating phenothiazine derivatives with acetic anhydride. A theoretical explanation for the chemoselectivity and regioselectivity of these acylation reactions applied to phenothiazine substrates was attempted by molecular-modeling analyses based on molecular mechanics, and semi-empirical and DFT calculations.
2019 ◽
Vol 55
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pp. 1407-1415
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Vol 28
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pp. 1769-1775
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2017 ◽
Vol 174
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pp. 182-194
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2009 ◽
Vol 930
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pp. 9-14
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2019 ◽
Vol 1194
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pp. 211-226
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2020 ◽
Vol 95
(5)
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pp. 534-547
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