Comparative Study Between Thermal Heating and Microwave-Assisted Synthesis for New Series of Phenothiazine Derivatives

A comparative study of microwave-assisted (MA) and conductive heating in RAFT dispersion polymerization formulations in MeOH that result in polymerization-induced self-assembly is detailed.

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Microwave Assisted Synthesis of 6-Aryl-3-substituted-5H-[1,2,4]-triazolo[4,3-b][1,2,4]triazoles: A Case for a Comparative Study

Phosphorus Sulfur and Silicon and the Related Elements ◽

10.1080/10426500214890 ◽

2002 ◽

Vol 177 (12) ◽

pp. 2923-2929 ◽

Cited By ~ 12

Author(s):

M. Rahimizadeh ◽

A. Davoodnia ◽

M. M. Heravi ◽

M. Bakavoli

Keyword(s):

Comparative Study ◽

Microwave Assisted Synthesis ◽

Microwave Assisted

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Microwave Assisted Synthesis, Characterization and Antimicrobial Activity of 10H-Phenothiazine Derivatives

Oriental Journal Of Chemistry ◽

10.13005/ojc/280428 ◽

2012 ◽

Vol 28 (4) ◽

pp. 1769-1775 ◽

Cited By ~ 2

Author(s):

G.S. KALWANIA ◽

S. CHOMAL ◽

S. CHOUDHARY ◽

RADHEY SHYAM ◽

SUNITA KUMARI

Keyword(s):

Antimicrobial Activity ◽

Microwave Assisted Synthesis ◽

Phenothiazine Derivatives ◽

Microwave Assisted

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Microwave Assisted Synthesis of Six Member Ring Azaheterocycles and Their Antimycobacterial and Anticancer Evaluation

Revista de Chimie ◽

10.37358/rc.20.3.7999 ◽

2001 ◽

Vol 71 (3) ◽

pp. 287-293 ◽

Cited By ~ 1

Author(s):

Cristina Al Matarneh ◽

Catalina-Ionica Ciobanu ◽

Violeta Mangalagiu ◽

Gheorghita Zbancioc ◽

Ramona Danac

Keyword(s):

Breast Cancer ◽

Prostate Cancer ◽

Lung Cancer ◽

Renal Cancer ◽

Reaction Times ◽

Antimycobacterial Activity ◽

Microwave Assisted Synthesis ◽

Thermal Heating ◽

Microwave Assisted ◽

Mw Irradiation

We report herein a comparative study concerning the influence of microwave (MW) irradiation comparative with conventional thermal heating (TH) in the reaction of six member ring azaheterocycles (derived from phenanthroline, quinoline, isoquinoline and phthalazine) with ethyl cyanoformate, and their anticancer and antimycobacterial activity. Under MW irradiation the reactions have some undeniable advantages: the reaction times decrease dramatically (from hours to minutes), the yields are higher, the reactions became selective in some cases (4,7-phenanthrolinium and phthalazinium ylides). The decreasing of reaction time+ from hours to minutes corroborated with the fact that in majority of cases the yield are higher and the selectivity is better, allow us to say that these reactions could be considered as eco-friendly. As far for biological activity, three of the compounds exhibited a significant antitumor activity against some cancer cell lines including prostate cancer, leukemia, renal cancer, lung cancer and breast cancer. The best potency in terms of growth inhibition of tumor cells (~45%) was shown by compound 4a against renal cancer A498 and ovarian cancer SK-OV-3 cells. The tested compounds have not shown any antimycobacterial activity against Mycobacterium tuberculosis.

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On the microwave-assisted synthesis of acylphenothiazine derivatives — Experiment versus theory synergism

Canadian Journal of Chemistry ◽

10.1139/v09-163 ◽

2010 ◽

Vol 88 (1) ◽

pp. 42-49 ◽

Cited By ~ 12

Author(s):

Luiza Gaina ◽

Dan Porumb ◽

Ioan Silaghi-Dumitrescu ◽

Castelia Cristea ◽

Luminita Silaghi-Dumitrescu

Keyword(s):

Molecular Modeling ◽

Acetic Anhydride ◽

Dft Calculations ◽

Theoretical Explanation ◽

Microwave Assisted Synthesis ◽

Phenothiazine Derivatives ◽

Microwave Assisted ◽

Experiment Versus ◽

Semi Empirical ◽

Acylation Reactions

The microwave-assisted synthesis of a series of acylphenothiazine derivatives is described. 10H-Phenothiazine-3-carbaldehyde derivatives were obtained in moderate yields by the Duff formylation reaction, and 10-acetyl-phenothiazine derivatives were obtained in excellent yields by acetylating phenothiazine derivatives with acetic anhydride. A theoretical explanation for the chemoselectivity and regioselectivity of these acylation reactions applied to phenothiazine substrates was attempted by molecular-modeling analyses based on molecular mechanics, and semi-empirical and DFT calculations.

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