PREPARATION OF 1-C14 PENTONIC ACIDS BY THE CYANHYDRIN SYNTHESIS

1954 ◽  
Vol 32 (4) ◽  
pp. 334-339 ◽  
Author(s):  
A. C. Neish
Keyword(s):  
Equimolar Amount ◽  
Radioactive Carbon ◽  
Xylonic Acid

Solutions of pure D-threose and D-erythrose, buffered with bicarbonate (0.82 moles) plus carbonate (0.18 moles), were treated with an equimolar amount of C14-labeled KCN. The aldonic acids were isolated as salts, using carrier technique, in yields of 90–95% based on the radioactive carbon. D-Erythrose gave 1.89 times as much arabonic as ribonic acid while D-threose gave 2.36 times as much lyxonic as xylonic acid. Despite the unfavorable ratio in the latter case it was found that D-xylose could be obtained in an over-all yield of 22%, based on the cyanide.

Synthesis of Some New Tetracyclic Pyrimidine Derivatives Using Exocyclic α,β-Unsaturated Ketone and Evaluation of Their Antitumor Activities

2016 ◽  
Vol 12 (8) ◽  
pp. 311-317
Author(s):  
Kamelia El-Mahdy
Keyword(s):  
Antitumor Activity ◽  
Spectroscopic Data ◽  
Acid Hydrazide ◽  
Chloroacetic Acid ◽  
Equimolar Amount ◽  
Unsaturated Ketone ◽  
Cyanoacetic Acid ◽  
Antitumor Activities ◽  
Pyrimidine Derivatives ◽  
Cyanoacetic Acid Hydrazide

Thiazolopyrimidine 2 was obtained from the reaction of dihydropyrimidinone with chloroacetic acid and benzaldehyde. Thiazolopyrimidine 2 containing an α,β-unsaturated ketonic function [-CH=CH-CO-] has been used as a component of Michael addition with an equimolar amount of dinucleophiles to give a series of novel tetracyclic pyrimidine derivatives. Treatment of thiazolopyrimidine 2 with uracil, aminotriazole, cyanoacetic acid hydrazide, o-phenylenediamine or diaminopyridine afforded the corresponding pyridopyrimidine, triazolopyrimidine, pyrazolone, benzodiazepine and triazepine derivative, respectively. The detailed synthesis, spectroscopic data, and antitumor activity for synthesized compounds were reported.

scholarly journals STUDIES IN PROTEIN METABOLISM WITH COMPOUNDS LABELED WITH RADIOACTIVE CARBON

1948 ◽  
Vol 173 (1) ◽  
pp. 189-197 ◽  
Author(s):  
Theodore Winnick ◽  
Felix Friedberg ◽  
David M. Greenberg
Keyword(s):  
Protein Metabolism ◽  
Radioactive Carbon

Latent Patterned Surface Metallization of Silver Ion-Doped Polyimide Films

2009 ◽  
Vol 1192 ◽  
Author(s):  
Luke M. Davis ◽  
Tyler S. Stukenbroeker ◽  
Christopher J. Abelt ◽  
Joseph L. Scott ◽  
Evguenia Orlova ◽  
...  
Keyword(s):  
Ambient Temperature ◽  
Reducing Agents ◽  
Equimolar Amount ◽  
Silver Ion ◽  
Polyimide Films ◽  
Patterned Surface ◽  
Specular Reflectivity ◽  
Surface Metallization ◽  
Polycrystalline Silver

AbstractA straightforward ambient temperature route to the fabrication of surface silver-metallized polyimide films is described. Silver(I) trifluoromethane sulfonate and a polyimide, derived from 2,2-bis(3,4-dicarboxyphenyl)hexafluoropropane dianhydride (6FDA) and an equimolar amount of 4,4'-oxydianiline (ODA) and 3,5-diaminobenzoic acid (DABA), were dissolved together in dimethylacetamide. Silver(I)-doped films were prepared at thicknesses of 25-50 microns and depleted of solvent by evaporation. The silver(I)-containing films were then treated with aqueous reducing agents, which brought forth silvered films exhibiting conductivity on the order of bulk polycrystalline silver and good specular reflectivity.

scholarly journals BIOSYNTHESIS OF URIC ACID LABELED WITH RADIOACTIVE CARBON

1949 ◽  
Vol 177 (2) ◽  
pp. 597-599 ◽  
Author(s):  
J.L. Karlsson ◽  
H.A. Barker
Keyword(s):  
Uric Acid ◽  
Radioactive Carbon

A pH-responsive genetic sensor for the dynamic regulation of D-xylonic acid accumulation in Escherichia coli

2020 ◽  
Vol 104 (5) ◽  
pp. 2097-2108
Author(s):  
Angelo B. Bañares ◽  
Kris Niño G. Valdehuesa ◽  
Kristine Rose M. Ramos ◽  
Grace M. Nisola ◽  
Won-Keun Lee ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Ph Responsive ◽  
Dynamic Regulation ◽  
Xylonic Acid ◽  
Acid Accumulation

Synthesis and structure of large 24-mer and 36-mer oxamate-based macrocycles

2017 ◽  
Vol 72 (7) ◽  
pp. 461-474 ◽  
Author(s):  
Saddam Weheabby ◽  
Mohammad A. Abdulmalic ◽  
Evgeny A. Kataev ◽  
Tatiana A. Shumilova ◽  
Tobias Rüffer
Keyword(s):  
Oxalyl Chloride ◽  
Spectroscopic Studies ◽  
Equimolar Amount ◽  
X Ray Diffraction ◽  
Intermolecular Hydrogen Bonds ◽  
X Ray ◽  
Accessible Volume ◽  
Hydrogen Bond Interactions ◽  
Work Up ◽  
Solid State Structures

AbstractPoly(cyclic) oxamates represent novel and potentially multidentate ligands for coordination chemistry. To obtain them, the treatment of 2-nitroaniline with two equivalents of oxalyl chloride afforded N,N′-bis(2-nitrophenyl)oxalamide (1), and by reduction of 1 with [NH4][CO2H] and Pd/C, N,N′-bis(2-aminophenyl)oxalamide (2, bapoxH6) was synthesized. After the addition of an equimolar amount of oxalyl chloride to a THF solution of 2 and aqueous work-up the 24-membered macrocycle H8L2 was obtained. In analogues experiments, the addition of ethoxalyl and oxalyl chloride to 2 afforded the 36-membered macrocycle H12L3. The addition of Cu(OAc)2·H2O and NaOH to 2 gave rise to the formation of [Cu2(bapoxH4)(OAc)2] (4). The identities of 1, 2 and H8L2 were determined by elemental analysis, IR, NMR spectroscopic studies and by mass spectrometry. The solid state structures of H8L2, H12L3 and 4 have been determined by single-crystal X-ray diffraction studies. Macrocycle H12L3 forms chains through intermolecular hydrogen bonds, while packing of 4 consists of layers held by intermolecular dispersion and hydrogen bond interactions. 24-mer H8L2 forms a cavity with a diameter of about 7.5 Å corresponding to an accessible volume of about 120 Å3 according to the well-established 55% solution and was found to bind bromide and iodide anions selectively.

scholarly journals METABOLISM OF LACTIC ACID CONTAINING RADIOACTIVE CARBON IN THE α OR β POSITION

1942 ◽  
Vol 142 (1) ◽  
pp. 371-377 ◽  
Author(s):  
Birgit Vennesland ◽  
A.K. Solomon ◽  
John M. Buchanan ◽  
Richard D. Cramer ◽  
A. Baird Hastings
Keyword(s):  
Lactic Acid ◽  
Radioactive Carbon
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