Parvifloracin and parviflorin: cytotoxic bistetrahydrofuran acetogenins with 35 carbons from Asimina parviflora (Annonaceae)

1994 ◽  
Vol 72 (2) ◽  
pp. 287-293 ◽  
Author(s):  
Sunil Ratnayake ◽  
Zhe-Ming Gu ◽  
Laura R. Miesbauer ◽  
David L. Smith ◽  
Karl V. Wood ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Test Data ◽  
Solid Tumor ◽  
Brine Shrimp ◽  
Tumor Cell Lines ◽  
Brine Shrimp Lethality ◽  
Human Solid Tumor ◽  
First Time

Using lethality to brine shrimp, activity-directed fractionation of extracts of Asimina parviflora (Michx.) Dunal. (Annonaceae) has led to the isolation of two new and four known acetogenins (1–6). Compound 1, parvifloracin, is the first nonadjacent bistetrahydrofuran acetogenin with 35 carbons. Compound 2, parviflorin, is an unusual adjacent bistetrahydrofuran acetogenin with 35 carbons. Bullatacin (3), molvizarin (4), annonacin (5), and goniothalamicin (6) are also reported for the first time from this plant. Brine shrimp lethality test data and comparative cytotoxicities of 1–6 against three human solid tumor cell lines are presented.

Antiproliferative activity of novel benzo[b][1,6]naphthyridines in human solid tumor cell lines

2010 ◽  
Vol 20 (5) ◽  
pp. 1504-1506 ◽  
Author(s):  
Simonas Rudys ◽  
Carla Ríos-Luci ◽  
Eduardo Pérez-Roth ◽  
Inga Cikotiene ◽  
José M. Padrón
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Solid Tumor ◽  
Antiproliferative Activity ◽  
Tumor Cell Lines ◽  
Human Solid Tumor

scholarly journals Lipophilic Salirasib analogs with enhanced antiproliferative activity against human solid tumor cell lines

2021 ◽  
Author(s):  
Exequiel O. J. Porta ◽  
María Sol Ballari ◽  
José M. Padrón ◽  
Guillermo R. Labadie
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Cancer Cell ◽  
Solid Tumor ◽  
Antiproliferative Activity ◽  
In Silico ◽  
Tumor Cell Lines ◽  
Human Solid Tumor ◽  
Physicochemical Features ◽  
Sar Analysis

Aim: We proposed to determine the antiproliferative activity of a series of synthetic salirasib analogs, presenting or not a 1,2,3-triazole linker, against five different cancer cell lines. Results: Bioassay, cheminformatic, and in silico ADME-Tox allowed the identification of new potent analogs. SAR analysis allowed the identification of structural and physicochemical features that benefit the antiproliferative activity. Conclusion: Isoprenyl R chains with three or more isoprene units, or long aliphatic R chains are the preferred ones within the active compounds. Likewise, we have identified three compounds with better activity profiles than salirasib against all the cell lines tested.

scholarly journals Glutamine as a Regulator of DNA and Protein Biosynthesis in Human Solid Tumor Cell Lines

1996 ◽  
Vol 224 (2) ◽  
pp. 189-197 ◽  
Author(s):  
Masafumi Wasa ◽  
Barrie P. Bode ◽  
Steven F. Abcouwer ◽  
Cynthia L. Collins ◽  
Kenneth K. Tanabe ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Solid Tumor ◽  
Protein Biosynthesis ◽  
Tumor Cell Lines ◽  
Human Solid Tumor

scholarly journals Cytotoxic Bioactivity of Some Phenylpropanoic Acid Derivatives

2012 ◽  
Vol 7 (10) ◽  
pp. 1934578X1200701 ◽  
Author(s):  
Guillermo F. Reta ◽  
Carlos E. Tonn ◽  
Carla Ríos-Luci ◽  
Leticia G. León ◽  
Eduardo Pérez-Roth ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Solid Tumor ◽  
Tumor Cell Lines ◽  
Molecular Scaffold ◽  
Human Solid Tumor ◽  
Antiproliferative Activities

In this study, we synthesized a series of phenylpropanoic acid derivatives based on modifications at four selected points of the molecular scaffold. The in vitro antiproliferative activities of the compounds were examined in representative human solid tumor cell lines. A SAR was established pointing out the relevance of the substituents. The best activity profiles were obtained for the derivatives bearing more lipophilic esters (GI50 3.1-21 μM).

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