ON THE RELATIONSHIP BETWEEN DRUG-INDUCED CHANGES IN BRAIN AMINES AND BODY TEMPERATURE

1967 ◽  
Vol 45 (4) ◽  
pp. 723-732 ◽  
Author(s):  
Alphonse J. Ingenito ◽  
Desmond D. Bonnycastle

To test the previously reported theory that changes in brain amine levels caused by drugs would lead to disturbances in body temperature regulation, the levels of 5-hydroxytryptamine and noradrenaline in the whole brain of male albino rats were determined after the animals were treated with drugs and then exposed to room temperature or elevated temperatures of 37 or 40 °C. Control experiments with untreated animals were run in parallel. The drugs used were reserpine, α-methyl-m-tyrosine (MMT), 4-chloro-N-methyl-amphetamine, 3,4-dihydroxyphenyl-L-alanine (dopa), 5-hydroxy-DL-tryptophan (5-HTP), chlorpromazine, and 2,4-dinitrophenol. The results indicated that amine levels of the brain could be increased or decreased pharmacologically without a significant interference in body temperature regulation, and also that certain drugs which interfered with body temperature regulation did so without any effect on whole-brain amine levels. It was concluded that, in the rat, there were no clear-cut relationships between whole-brain 5-hydroxytryptamine or noradrenaline levels and the ability to regulate body temperature.


1994 ◽  
Vol 72 (3) ◽  
pp. 427-432 ◽  
Author(s):  
Myra O. Wiebe ◽  
Roger M. Evans

Endothermic thermoregulation is absent in birds until after hatching, and usually requires several hours or days to become fully functional in the young. Cold-induced vocalizations that elicit brooding by a cooperative parent or surrogate constitute an additional thermoregulatory mechanism potentially available to neonates of some avian and probably some mammalian species. We show that newly hatched ring-billed gulls (Larus delawarensis) and herring gulls (Larus argentatus) exposed in the laboratory to moderate chilling (20 °C) had a significantly improved ability to regulate body temperature when rewarmed (34 °C) for brief, 4-min periods in response to cold-induced vocalizations. Spontaneous calling by unchilled yoked controls was ineffective in maintaining body temperature. When chicks reached 3 days of age, vocally regulated temperaturee did not differ from that attained by thermogenesis, but vocally induced periods of rewarming reduced the duration of temperature challenge. The ability to regulate body temperature through vocalizations precedes the development of endothermy in gulls and other species so far examined, and in some species extends functional thermoregulation back to the late embryonic (pipped egg) stage of development.





2012 ◽  
pp. 459-469 ◽  
Author(s):  
M. Willershäuser ◽  
N. Ehrhardt ◽  
R. Elvert ◽  
E. K. Wirth ◽  
U. Schweizer ◽  
...  




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