Effects of Crosslinked Polyhemoglobinsuperoxide dismutase-catalase on Blood-Brain Barrier and Brain Edema in a Hemorrhagic Shock Transient Global Ischemia Rat Model

2021 ◽  
pp. 505-527
Author(s):  
D Douglas Powanda ◽  
Thomas MS Chang
Keyword(s):  
Hemorrhagic Shock ◽  
Brain Edema ◽  
Blood Brain Barrier ◽  
Rat Model ◽  
Global Ischemia ◽  
Brain Barrier ◽  
Blood Brain ◽  
Transient Global Ischemia

Blood-Brain Barrier Sodium Transport and Brain Edema Formation

1995 ◽  
pp. 159-168 ◽  
Author(s):  
A. Lorris Betz ◽  
Steven R. Ennis ◽  
Xiao-dan Ren ◽  
Gerald P. Schielke ◽  
Richard F. Keep
Keyword(s):  
Brain Edema ◽  
Blood Brain Barrier ◽  
Sodium Transport ◽  
Brain Barrier ◽  
Edema Formation ◽  
Blood Brain ◽  
Brain Edema Formation

scholarly journals Blood-brain barrier disruption and angiogenesis in a rat model for neurocysticercosis

2018 ◽  
Vol 97 (2) ◽  
pp. 137-148 ◽  
Author(s):  
Rogger P. Carmen-Orozco ◽  
Danitza G. Dávila-Villacorta ◽  
Yudith Cauna ◽  
Edson G. Bernal-Teran ◽  
Leandra Bitterfeld ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Rat Model ◽  
Brain Barrier ◽  
Barrier Disruption ◽  
Blood Brain Barrier Disruption ◽  
Blood Brain ◽  
Brain Barrier Disruption

scholarly journals Glycocalyx degradation leads to blood–brain barrier dysfunction and brain edema after asphyxia cardiac arrest in rats

2017 ◽  
Vol 38 (11) ◽  
pp. 1979-1992 ◽  
Author(s):  
Jiajia Zhu ◽  
Xing Li ◽  
Jia Yin ◽  
Yafang Hu ◽  
Yong Gu ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Survival Rate ◽  
Brain Edema ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Neurologic Outcome ◽  
Endothelial Glycocalyx ◽  
Inflammatory Factors ◽  
Blood Brain ◽  
Bbb Permeability

The role of glycocalyx in blood–brain barrier (BBB) integrity and brain damage is poorly understood. Our study aimed to investigate the impacts of endothelial glycocalyx on BBB function in a rat model of cardiac arrest (CA) and cardiopulmonary resuscitation (CPR). Male Sprague-Dawley rats subjected to 8-min asphyxia CA/CPR. Compared to controls, glycocalyx was mildly injured by CA, severely disrupted by hyaluronidase (HAase) with CA, and mitigated by hydrocortisone (HC) with CA. More importantly, the disruption of glycocalyx caused by HAase treatment was associated with higher BBB permeability and aggravated brain edema at 24 h after return of spontaneous circulation, as well as lower survival rate and poorer neurologic outcome at seventh day. Reversely, less degradation of glycocalyx by HC treatment was accompanied by higher seven-day survival rate and better neurologic outcome. Mechanistically, HAase treatment further increased CA/CPR-induced activation of glia cells and expression of inflammatory factors, whereas HC decreased them in the brain cortex and hippocampus. Glycocalyx degradation results in BBB leakage, brain edema, and deteriorates neurologic outcome after asphyxia CA/CPR in rats. Preservation of glycocalyx by HC could improve neurologic outcome and reduce BBB permeability, apparently through reduced gene transcription-protein synthesis and inflammation.

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