The intensity and duration of preservation of the immune response to viral hepatitis B after vaccination among the medical staff of the polyclinic was studied. Some features of postvaccinal immunity in medical staff were revealed. In 39.2 % of the surveyed, postvaccinal antibodies were not detected or their level was lower than protective, which is the basis for a course of vaccinations against the HV virus in this group of persons in the absence of contraindications for vaccination. The intensity of post-vaccination immunity to the HV virus among different groups of medical personnel of the polyclinic depends on the type of professional activity.