Non-canonical structures of nucleic acids inhibit or dysregulate biological reactions related to diseases. To control the reactions, methods for inducing the non-canonical structures have been developed using small molecules and oligonucleotides.
Biomolecules and bionanoparticles, such as nucleic acids, proteins, microorganisms and extracellular vesicles (EVs), are recognized as important targets for fundamental research, clinical diagnostic and therapeutic applications. To gain detailed information of those bionanoparticles, we demonstrate an electroosmotic (EO) driven transport behavior in silicon and silicon nitride-based nanopore, towards an accurate measure of concentration and sizing of sub-micro particles for a general biological interest.
Catalytic nucleic acids (DNAzymes) provide functional modules for logic gates and computing operations, and hold great promise for biomedical sensing and therapeutic applications.
Therapeutic Applications of Nucleic Acids and Their Analogues in Toll-like Receptor Signaling