TRACE ELEMENTS IN SERA FROM PATIENTS WITH VISCERAL LEISHMANIASIS

2000 ◽  
Vol 10 (01n02) ◽  
pp. 11-18 ◽  
Author(s):  
R. Mukhopadhyay ◽  
A. Chakraborty ◽  
M. Sudarshan ◽  
R. K. Dutta ◽  
P. K. Jal ◽  
...  

Trace elements are known to have pivotal role in human health and disease. Present investigation employed PIXE analysis to probe into the elemental profile of patients suffering from visceral Leishmaniasis. Remarkable alterations were observed in concentration of elements like Cl , K , Ca , Mn , Fe , Cu , Zn . The pattern of enhancement of elemental concentration corresponds to the progression of the disease. Additionally, our present data reflect probable correlation between alteration in trace elemental status and other pathological syndromes associated with Leishmaniasis. The possibility of considering trace elements as a diagnostic marker for a better understanding of the disease is discussed.

2012 ◽  
Vol 22 (01n02) ◽  
pp. 101-106 ◽  
Author(s):  
K. IGARI ◽  
A. TAKAHASHI ◽  
N. GOTOH ◽  
K. SASAKI ◽  
K. ISHII ◽  
...  

Naturally shed deciduous teeth are potentially useful as a biomarker of environmental exposure. To assess the prenatal environment of child, we tried to present the neonatal line on the elemental maps and investigate the trace elements in pre- and post-natally formed tooth enamel using micro-PIXE. Generally, the neonatal line is observed more clearly in the tooth from child who has some difficulties at birth. In this study, five deciduous teeth from five children with developmental disorders were used for analysis. Seven trace elements ( Na , Mg , Si , Cl , Fe , Zn , and Sr ) were detected in enamel of all five teeth. The line, it was thought neonatal line, was observed on the elemental map of Ca and P in the tooth from the child with serious birth complications. In order to compare the elemental concentration between pre- and post-natal enamel, concentration variation of elements were projected along the line perpendicular to the neonatal line. Lower Ca concentration in prenatal enamel was observed. By tracing the location of neonatal line on the other elemental maps, the concentrations of detected trace elements were compared in the same way. The differences of concentration of these trace elements between pre- and post-natal enamel were not clear because of much statistic variation. We could determine the trace elemental profiles and concentrations around the neonatal line in the enamel from the child with serious birth complications.


2003 ◽  
Vol 13 (03n04) ◽  
pp. 97-106 ◽  
Author(s):  
S. VATANKHAH ◽  
K. MOOSAVI ◽  
H. PEYROVAN ◽  
J. SALIMI

Structural composition of 11 trace elements with Z greater than 13 ( Al , P , Si , K , Ca , Mn , Fe , Cu , Zn , Mo , I ) was analyzed for the two main groups of human gallstones according to their cholesterol and pigment types by PIXE (Proton Induced X - ray Emission). In both types of stones, the shell and the center were analyzed separately. The gallstones were obtained from 12 patients in wide age group from 22 to 78 years of age during surgical operation. The results show relatively higher values of heavy elements for ages greater than 40. The values of phosphorous in cholesterol type stones are significantly higher than in those of pigment stones. The concentration of calcium in the center of stones is large in comparison with that in the shells. In this paper, a correlation between stone structure and trace elemental concentration has been presented. Comparison of the two essential types of stones (cholesterol and pigment) shows that the center of the pigment stones is very similar to that of the cholesterol type.


2004 ◽  
Vol 14 (03n04) ◽  
pp. 75-81 ◽  
Author(s):  
H. KOMORI ◽  
K. MIZUMA ◽  
K. ISHII ◽  
H. YAMAZAKI ◽  
S. MATSUYAMA ◽  
...  

The change of shape and elemental concentration of cellular samples in In-Air micro PIXE analysis was investigated. Cultured bovine aortic endothelial cells were analyzed in the atmosphere by using 2.6 MeV proton micro-beams. The shape of cross-sections of cells was not so much distorted by beam irradiation and the concentrations of trace elements did not change too, except for S. The concentration of S changed with strongly depending on the temperature rise due to beam irradiation.


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