Anti-hepatitis C Virus Effect of Citrus Unshiu Peel and Its Active Ingredient Nobiletin
2005 ◽
Vol 33
(01)
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pp. 87-94
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Keyword(s):
We investigated the effects of water and ethyl acetate extracts of Citrus unshiu peel (Aurantii Nobilis pericarpium) on hepatitis C virus (HCV) absorption in MOLT-4 cells (a human lymphoblastoid leukemia cell line). By reverse transcription polymerase chain reaction (RT-PCR), we showed that both the ethyl acetate layer of Citrus unshiu peel extract and fraction 7 decreased HCV absorption in MOLT-4 cells. Furthermore, we demonstrated that 3′,4′,5,6,7,8-hexamethoxyflavone (nobiletin) is the active ingredient that markedly inhibited HCV infection in MOLT-4 cells.
Keyword(s):
1995 ◽
Vol 146
(5)
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pp. 363-370
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1992 ◽
Vol 37
(4)
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pp. 310-314
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1997 ◽
Vol 66
(1)
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pp. 15-18
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2016 ◽
Vol 8
(9)
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pp. 111
1993 ◽
Vol 128
(3)
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pp. 359-360
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1995 ◽
Vol 25
(1)
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pp. 52-54
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