Effect ofBauhinia racemosaStem Bark on N-nitrosodiethylamine-Induced Hepatocarcinogenesis in Rats

2007 ◽  
Vol 35 (01) ◽  
pp. 103-114 ◽  
Author(s):  
Ramanathan Sambath Kumar ◽  
Rajagopal Shanmuga Sunderam ◽  
Thangavel Sivakumar ◽  
Palanivel Sivakumar ◽  
Raman Sureshkumar ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Uric Acid ◽  
Antioxidant Defense ◽  
Methanol Extract ◽  
Reduced Glutathione ◽  
Antioxidant Defense System ◽  
Serum Enzymes ◽  
Nodule Development ◽  
Albino Rats ◽  
Defense System

The aim of this study is to investigate the antioxidant defense system induced by the methanol extract of Bauhinia racemosa L.(MEBR) against N-nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis in Wister albino rats. The effects of MEBR on surface visible macroscopic (Morphometry) liver lesions (neoplastic nodules) and the levels of serum enzymes, lipid peroxidation and antioxidants were evaluated in NDEA-induced hepatocarcinogenesis in rats.In rats treated, with NDEA, significantly elevated levels of serum enzymes (SGOT, SGPT and ALP), bilirubin and decreased levels of protein and uric acid were observed. Significantly elevated amount of malondialdehyde (MDA), the end product of lipidperoxidation, indicated higher levels of lipid peroxidation, which was accompanied by significantly decreased levels of antioxidants like vitamin C, vitamin E, reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT). Administration of MEBR was able to suppress nodule development/hepatocellular lesion formation in rats. The extract treatment increases in antioxidant levels and dramatic decreases in lipid peroxidation levels. MEBR also produced a protective effect by decreasing the level of serum enzymes, bilirubin and increased the protein and uric acid levels. The results suggest that MEBR exert chemopreventive effects by suppressing nodule development and decreasing lipid peroxidation and enhancing the levels of antioxidants in NDEA carcinogenesis by reducing the formation of free radicals.

scholarly journals Influence of cadmium loading on the state of the antioxidant system in the organism of bulls

2016 ◽  
Vol 24 (1) ◽  
pp. 96-102 ◽  
Author(s):  
B. V. Gutyj ◽  
S. D. Mursjka ◽  
D. F. Hufrij ◽  
I. I. Hariv ◽  
N. D. Levkivska ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Antioxidant System ◽  
Cadmium Chloride ◽  
Antioxidant Defense ◽  
Reduced Glutathione ◽  
Antioxidant Defense System ◽  
Defense System ◽  
Young Cattle

This article presents the results of research on the influence of cadmium loading on the state level of enzymatic and non-enzymatic antioxidant links of the antioxidant defense system of the organisms of young cattle, such as the activity of catalase, superoxide dismutase, glutathione peroxidase, glutathione levels, selenium, vitamins A and E. It was found that feeding bull calves with cadmium chloride at doses of 0.03 and 0.05 mg/kg of body weight helped to reduce both the enzymatic and non-enzymatic link of antioxidant protection (superoxide dismutase 31%, catalase 13%, glutathione peroxidase 23%, reduced glutathione 10%, vitamin A 28%, vitamin E 31%, selenium 20%). Toxic effects of cadmium promotes change in steady-state concentrations of radical metabolites О2–,ОН˙, НО2˙, which, in turn, trigger the process of lipid peroxidation. The lowest level of indicators of antioxidant defense system in the blood of young cattle was registered on the sixteenth and twenty-fourth days of the experiment, which is associated with increased activation of lipid peroxidation and the disturbaance of the balance between the antioxidant system and lipid peroxidation intensity. The activity of the antioxidant defense system in the blood was different for calves fed with cadmium chloride at doses of 0.03 and 0.05 mg/kg of animal mass. The more cadmium chloride in the feed, the lower the activity of the antioxidant defense system of the calves’ organisms was registered. Thus cadmium chloride depresses the antioxidant defense system, which specifically involves lowering the activity of enzymatic links (catalase, superoxide dismutase, glutathione peroxidase) and non-enzymatic links (reduced glutathione, selenium, vitamins A and E).

Influence of ellagic acid on antioxidant defense system and lipid peroxidation in mice

1991 ◽  
Vol 42 (7) ◽  
pp. 1441-1445 ◽  
Author(s):  
Sabhiya Majid ◽  
Krishan L. Khanduja ◽  
Rajinder K. Gandhi ◽  
Sanjay Kapur ◽  
Rati R. Sharma
Keyword(s):  
Lipid Peroxidation ◽  
Ellagic Acid ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Defense System

scholarly journals On the Opportunities of Using the Indices of Lipid Peroxidation – Antioxidant Defense System in the Diagnostics of Varicose Veins of Small Pelvis in Women

2020 ◽  
Vol 5 (1) ◽  
pp. 14-20
Author(s):  
L. I. Kolesnikova ◽  
A. A. Semendyaev ◽  
D. A. Stupin ◽  
M. A. Darenskaya ◽  
L. A. Grebenkina ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Defense ◽  
Varicose Veins ◽  
Antioxidant Defense System ◽  
Pathological Process ◽  
Moderate Degree ◽  
Defense System ◽  
Mild Degree ◽  
Severe Degree ◽  
Degree Of Severity

Background: The prevalence of varicose veins of small pelvic veins in women of reproductive age varies widely – from 5.4 to 80 %, due to the low specificity and low sensitivity of clinical diagnostic techniques, and the absence of biomarkers that can be used to identify the formation and progression of varicose veins of small pelvic veins in women.Aims: To identify changes in the levels of parameters of the system “lipid peroxidation – antioxidant protection” with the development of varicose veins of the pelvis in women, as well as the possibility of their diagnostic use.Materials and methods: We examined 200 women with clinical signs of varicose veins of small pelvis. Control group included 30 women without any pathology of venous system. Treatment group included 137 women with varicose veins of small pelvis: with mild degree of severity – 39 women, with moderate degree of severity – 65 women, with severe degree of severity – 33 women. We performed comparative analysis of lipid peroxidation – antioxidant defense system in women with and without varicose veins of small pelvis taking into account the severity degrees of pathological process.Results: We obtained the most informative indices for lipid peroxidation – antioxidant defense processes in blood of women with varicose veins of small pelvis: concentration of diene conjugate (DC) for the mild degree of severity of pathological process, lipid hydroperoxide (LHP), DC and malonic dialdehyde (MDA) – for the moderate and severe degree of severity, and also changes in the activity of antioxidant enzymes with increase of the severity of the disease. Assessment of the level of catalase (Cat) and glutathione peroxidase (GP) showed their highest informative value at the mild degree of severity. Concentrations of glutathione reductase (GR), glutathione S-transferase (GST) and reduced glutathione (GSH) are more statistically significant markers for severe forms of pathological process.Conclusions: Our research showed the relevance and advisability of the studying the levels of lipid peroxidation – antioxidant defense indices in women with varicose veins of small pelvis. We registered the highest diagnostic value of DC, Cat and GP in the beginning of the disease and of LHP, DC, MDA, GR, GST and GSH – at severe forms of the pathological process. We obtained reference values for DC, MDA, Cat, SOD and GP concentration that can be considered as the predictors of the development of varicose veins of small pelvis.

Evaluation of Lipid Peroxidation—Antioxidant Defense System Depending on the Stage of Stress Reaction in Hypertensive ISIAH Rats

2019 ◽  
Vol 166 (5) ◽  
pp. 610-612
Author(s):  
L. I. Kolesnikova ◽  
L. R. Kolesnikova ◽  
M. A. Darenskaya ◽  
L. V. Natyaganova ◽  
L. A. Grebenkina ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Stress Reaction ◽  
Defense System ◽  
Isiah Rats ◽  
Hypertensive Isiah Rats
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