Smilax riparia Reduces Hyperuricemia in Mice as a Potential Treatment of Gout

2014 ◽  
Vol 42 (01) ◽  
pp. 257-259 ◽  
Author(s):  
Xiao-Hui Wu ◽  
Chun-Hao Yu ◽  
Chun-Feng Zhang ◽  
Samantha Anderson ◽  
Yan-Wen Zhang
Keyword(s):  
Uric Acid ◽  
Chinese Medicine ◽  
Herbal Medicine ◽  
Traditional Chinese Medicine ◽  
Mouse Model ◽  
Potential Treatment ◽  
Acid Excretion ◽  
Uric Acid Excretion ◽  
Therapeutic Activities ◽  
Potassium Oxonate

The roots and rhizomes of Smilax riparia, called "Niu-Wei-Cai" in traditional Chinese medicine (TCM), are believed to be effective in treating gout symptoms. However, it is not clear if the uricosuric mechanisms of S. riparia support its therapeutic activities. In this study, we examined the efficacy of S. riparia in reducing serum uric acid levels in a potassium oxonate-induced hyperuricemia mouse model. We observed that the total saponins of S. riparia could down-regulate renal mURAT1, resulting in the enhancement of urate excretion in the kidney of hyperuricemic mice. These results suggest that S. riparia could be an active anti-gout herbal medicine, which would contribute to the enhancement of uric acid excretion in the kidney.

scholarly journals The Time-Feature of Uric Acid Excretion in Hyperuricemia Mice Induced by Potassium Oxonate and Adenine

2020 ◽  
Vol 21 (15) ◽  
pp. 5178
Author(s):  
Shaoshi Wen ◽  
Dan Wang ◽  
Haiyang Yu ◽  
Mengyang Liu ◽  
Qian Chen ◽  
...  
Keyword(s):  
Renal Function ◽  
Uric Acid ◽  
Mouse Model ◽  
Uric Acid Level ◽  
Acid Level ◽  
Acid Excretion ◽  
Mice Model ◽  
Uric Acid Excretion ◽  
Plasma Uric Acid ◽  
Potassium Oxonate

Hyperuricemia is an important risk factor of chronic kidney disease, metabolic syndrome and cardiovascular disease. We aimed to assess the time-feature relationship of hyperuricemia mouse model on uric acid excretion and renal function. A hyperuricemia mouse model was established by potassium oxonate (PO) and adenine for 21 days. Ultra Performance Liquid Chromatography was used to determine plasma uric acid level. Hematoxylin-eosin staining was applied to observe kidney pathological changes, and Western blot was used to detect renal urate transporters’ expression. In hyperuricemia mice, plasma uric acid level increased significantly from the 3rd day, and tended to be stable from the 7th day, and the clearance rate of uric acid decreased greatly from the 3rd day. Further study found that the renal organ of hyperuricemia mice showed slight damage from the 3rd day, and significantly deteriorated renal function from the 10th day. In addition, the expression levels of GLUT9 and URAT1 were upregulated from the 3rd day, while ABCG2 and OAT1 were downregulated from the 3rd day, and NPT1 were downregulated from the 7th day in hyperuricemia mice kidney. This paper presents a method suitable for experimental hyperuricemia mouse model, and shows the time-feature of each index in a hyperuricemia mice model.

Hypouricemic Effects of Phenylpropanoid Glycosides Acteoside ofScrophularia ningpoensison Serum Uric Acid Levels in Potassium Oxonate-Pretreated Mice

2008 ◽  
Vol 36 (01) ◽  
pp. 149-157 ◽  
Author(s):  
Cai Guo Huang ◽  
Yan Jun Shang ◽  
Jun Zhang ◽  
Jian Rong Zhang ◽  
Wen Jie Li ◽  
...  
Keyword(s):  
Uric Acid ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Xanthine Oxidase ◽  
Serum Uric Acid ◽  
Mouse Liver ◽  
Xanthine Dehydrogenase ◽  
Phenylpropanoid Glycoside ◽  
Phenylpropanoid Glycosides ◽  
Potassium Oxonate

Phenylpropanoid glycoside acteoside was extracted from the traditional Chinese medicine Scrophularia ningpoenis Hemsl. In the present study, we investigated the effects of acteoside administration on serum uric acid levels in mice rendered hyperuricemic with the uricase inhibitor potassium oxonate. When administered orally for 3 days at doses of 50, 100 and 150 mg/kg, acteoside reduced serum uric acid levels by 15.2, 23.8 and 33.1%, respectively, relative to vehicle-treated hyperuricemic mice. Importantly, in non-hyperuricemic mice, the serum uric acid levels were not affected by acetoside treatment. Acteoside also inhibited mouse liver xanthine dehydrogenase XDH and xanthine oxidase XO activity at all three doses. These results suggest that the hypouricemic action of acteoside may be attributable to its inhibition of XDH/XO activity.

scholarly journals Synergistic Uric Acid-Lowering Effects of the Combination of Chrysanthemum indicum Linne Flower and Cinnamomum cassia (L.) J. Persl Bark Extracts

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Young-Sil Lee ◽  
Eunjung Son ◽  
Seung-Hyung Kim ◽  
Yun Mi Lee ◽  
Ohn Soon Kim ◽  
...  
Keyword(s):  
Uric Acid ◽  
Cinnamic Acid ◽  
Acid Excretion ◽  
Uric Acid Excretion ◽  
Cinnamomum Cassia ◽  
Activity Inhibition ◽  
Dicaffeoylquinic Acid ◽  
Chrysanthemum Indicum ◽  
Potassium Oxonate

Chrysanthemum indicum Linne flower (CF) and Cinnamomum cassia (L.) J. Persl bark (CB) extracts have served as the main ingredients in several prescriptions designed to treat hyperuricemia and gout in traditional Chinese and Korean medicine. However, little is known about the combination effects of a CF and CB (CC) mixture on hyperuricemia. In our study, we investigated the antihyperuricemic effects of CC mixture and the mechanisms underlying these effects in normal and potassium oxonate- (PO-) induced hyperuricemic rats. The CC mixture significantly decreased uric acid levels in normal and PO-induced hyperuricemic rats and showed the enhanced hypouricemic effect compared to CF or CB alone. Furthermore, the CC mixture increased renal uric acid excretion in PO-induced hyperuricemic rat. We found that CC mixture and its major components, chlorogenic acid, 3,4-dicaffeoylquinic acid (isochlorogenic acid), coumarin, cinnamaldehyde, trans-cinnamic acid, and o-methoxycinnamaldehyde, inhibit the activity of xanthine oxidase (XOD) in vitro. The CC mixture exerts antihyperuricemic effects accompanied partially by XOD activity inhibition. Therefore, the CC mixture may have potential as a treatment for hyperuricemia and gout.

Effect of urine flow rate on uric acid excretion in man

1972 ◽  
Vol 15 (4) ◽  
pp. 338-346 ◽  
Author(s):  
Herbert S. Diamond ◽  
Robert Lazarus ◽  
David Kaplan ◽  
David Halberstam
Keyword(s):  
Uric Acid ◽  
Flow Rate ◽  
Urine Flow ◽  
Urine Flow Rate ◽  
Acid Excretion ◽  
Uric Acid Excretion

scholarly journals Effect of pentose ingestion on uric acid excretion

1929 ◽  
Vol 23 (6) ◽  
pp. 1175-1177
Author(s):  
Kate Madders ◽  
Robert Alexander McCance
Keyword(s):  
Uric Acid ◽  
Acid Excretion ◽  
Uric Acid Excretion

scholarly journals POS1144 SERUM URIC ACID TO CREATININE RATIO IS ASSOCIATED WITH URINARY URIC ACID EXCRETION IN PATIENTS WITH GOUT

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 851.2-851
Author(s):  
Z. Zhong ◽  
Y. Huang ◽  
X. Huang ◽  
Q. Huang ◽  
Y. Liu ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Acid Output ◽  
Area Under The Curve ◽  
Roc Curves ◽  
Binary Logistic Regression Analysis ◽  
Creatinine Ratio ◽  
Acid Excretion ◽  
Complete Collection ◽  
Uric Acid Excretion

Background:Underexcretion of uric acid is the dominant mechanism leading to hyperuricemia [1] and the 24-hour urinary uric acid excretion is an important measurement. However, it is inconvenient due to accurate timing and complete collection of the specimen.Objectives:The aim of this study was to investigate the relationship between serum uric acid to creatinine ratio (sUACR) and 24-hour urinary uric acid excretion in gout patients.Methods:A total of 110 gout patients fulfilling 2015 ACR/EULAR classification criteria from Guangdong Second Provincial General Hospital from January 2019 to January 2021 were retrospectively enrolled in this study. Patients were divided into underexcretion group (<3600 μmol/24h) and non-underexcretion group (≥3600 μmol/24h). The correlation between sUACR and 24-hour urinary uric acid excretion was analyzed by the Pearson’s correlations analysis. Receiver operation characteristic (ROC) curves were performed to assess the utility of sUACR for discriminating between underexcretion group and non-underexcretion group. Furthermore, the risk factors of uric acid underexcretion were evaluated using binary logistic regression analysis.Results:sUACR in the underexcretion group was significantly lower than the non-underexcretion group (p=0.0001). Besides, sUACR was positively correlated with 24-hour urinary uric acid excretion (r=0.4833, p<0.0001). Furthermore, ROC suggested that the area under the curve (AUC) of sUACR was 0.728, which was higher that of serum uric acid and creatinine. The optimal cutoff point of sUACR was 5.2312, with a sensitivity and specificity of 71.9% and 67.9%. Logistic analysis results revealed that decreased sUACR (<5.2312) was an independent risk factor of underexcretion of uric acid (OR =5.510, 95% CI: 1.952-15.550, P=0.001).Conclusion:sUACR is lower in gout patients with underexcretion of uric acid and may serve as a useful and convenient marker of assessing underexcretion of uric acid in gout patients.References:[1]Perez-Ruiz F, Calabozo M, Erauskin GG, Ruibal A, Herrero-Beites AM. Renal underexcretion of uric acid is present in patients with apparent high urinary uric acid output. Arthritis Rheum 2002; 47: 610–13.Figure 1.A. Comparison of serum uric acid to creatinine ratio between underexcretion group and non-underexcretion group. B. Correlation between serum uric acid to creatinine ratio and 24h uric acid excretion.Disclosure of Interests:None declared.

Uric acid excretion in normal children

1978 ◽  
Vol 92 (6) ◽  
pp. 911-914 ◽  
Author(s):  
F. Bruder Stapleton ◽  
Michael A. Linshaw ◽  
Khatab Hassanein ◽  
Alan B. Gruskin
Keyword(s):  
Uric Acid ◽  
Acid Excretion ◽  
Normal Children ◽  
Uric Acid Excretion

Uric acid excretion in infants and children

1971 ◽  
Vol 32 (3) ◽  
pp. 377-383 ◽  
Author(s):  
Helen K. Berry ◽  
Mary Granger
Keyword(s):  
Uric Acid ◽  
Infants And Children ◽  
Acid Excretion ◽  
Uric Acid Excretion ◽  
In Infants And Children

scholarly journals THE EFFECTIVENESS OF RENALOF® COMPARED TO KALKURENAL® AND PLACEBO

2012 ◽  
Vol 19 (2) ◽  
Author(s):  
Benny Kristyantoro ◽  
Sabilal Alif ◽  
Tarmono Djojodimedjo ◽  
Budiono Budiono
Keyword(s):  
Uric Acid ◽  
Surface Area ◽  
Renal Calculi ◽  
Renal Calculus ◽  
Renal Ultrasound ◽  
Acid Excretion ◽  
Stone Surface ◽  
Adjunct Therapy ◽  
Uric Acid Excretion ◽  
Plain Abdominal Film

Objective: To compare the effectiveness after administration of Renalof to Kalkurenal and placebo in patient with renal calculus. Material & Method: We analyzed 30 patient with renal calculi less than or equal to 20 mm (2 cm) between January 2011 and March 2011. Patients were divided into 3 groups. Nine patients were treated with placebo, 8 patients were treated with Kalkurenal and the last 13 patients were treated with Renalof. After 30 days, we analyzed calcium and uric acid excretion for 24 hours and measured the stone with plain abdominal film and renal ultrasound. Results: There were decreased in excretion of calcium and uric acid all of patients but not significant statistically (p > 0,05) and there were significant decreased on stone measurement in patient treated with Renalof. Conclusion: Renalof  can be given as adjunct therapy for patient with renal calculi. Keywords: Calcium and uric acid excretion in urine 24 hours, stone measurement and stone surface area.

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