Clinical Study of Objective Pulse Diagnosis

1986 ◽  
Vol 14 (03n04) ◽  
pp. 179-183 ◽  
Author(s):  
Sook Hyang Yoon ◽  
Yoshihisa Koga ◽  
Isao Matsumoto ◽  
Etsutaro Ikezono
Keyword(s):  
Clinical Study ◽  
Healthy Volunteers ◽  
Pain Threshold ◽  
Acupuncture Analgesia ◽  
Pulse Diagnosis ◽  
Element Theory ◽  
Stimulation Of

The recording of the objective pulse diagnosis was performed and that meridian points were selected from this recording. The proper meridian points (five element points) according to the five element theory and the improper points (non-five element points) were stimulated. Pain threshold was elevated by the stimulation of five element points and not raised by non-five element points in a patient who had nasal ploypectomy under acupuncture analgesia and also in 6 of 9 healthy volunteers. Naloxone reversal of elevated pain threshold was also observed in volunteers.

scholarly journals Pulse Diagnosis Signals Analysis of Fatty Liver Disease and Cirrhosis Patients by Using Machine Learning

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Wang Nanyue ◽  
Yu Youhua ◽  
Huang Dawei ◽  
Xu Bin ◽  
Liu Jia ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Healthy Volunteers ◽  
Unsupervised Learning ◽  
Supervised Learning ◽  
Fatty Liver Disease ◽  
Principal Component ◽  
Identification Accuracy ◽  
Pulse Diagnosis ◽  
Significant Difference

Objective. To compare the signals of pulse diagnosis of fatty liver disease (FLD) patients and cirrhosis patients.Methods. After collecting the pulse waves of patients with fatty liver disease, cirrhosis patients, and healthy volunteers, we do pretreatment and parameters extracting based on harmonic fitting, modeling, and identification by unsupervised learning Principal Component Analysis (PCA) and supervised learning Least squares Regression (LS) and Least Absolute Shrinkage and Selection Operator (LASSO) with cross-validation step by step for analysis.Results. There is significant difference between the pulse diagnosis signals of healthy volunteers and patients with FLD and cirrhosis, and the result was confirmed by 3 analysis methods. The identification accuracy of the 1st principal component is about 75% without any classification formation by PCA, and supervised learning’s accuracy (LS and LASSO) was even more than 93% when 7 parameters were used and was 84% when only 2 parameters were used.Conclusion. The method we built in this study based on the combination of unsupervised learning PCA and supervised learning LS and LASSO might offer some confidence for the realization of computer-aided diagnosis by pulse diagnosis in TCM. In addition, this study might offer some important evidence for the science of pulse diagnosis in TCM clinical diagnosis.

CLINICAL INVESTIGATION IN PEDIATRIC PRACTICE

PEDIATRICS ◽  
1956 ◽  
Vol 18 (1) ◽  
pp. 90-94
Author(s):  
John C. Wilcox
Keyword(s):  
Clinical Study ◽  
Teaching Hospital ◽  
Clinical Investigation ◽  
Medical Knowledge ◽  
Academic Standards ◽  
Pediatric Practice ◽  
The World ◽  
Common Purpose ◽  
The Common ◽  
Stimulation Of

WHILE recognizing that the common purpose of all clinical investigation is the benefit of the patient through the advancement of medical knowledge, there are other justifications and sources of inspiration which may be more immediately gained objectives. This is true whether the investigator is a professor of pediatrics or his country cousin. It is the purpose of this paper to compare the natures of those immediate objectives as they apply to clinical investigation carried on in a teaching center with clinical investigation performed in pediatric practice. In making this comparison, I do not intend to imply that the professor of pediatrics or a member of his staff has at his beck and call large crews of laboratory technicians, roomtuis of pretty secretaries and efficient stenographers, tabulators and computers in frightening array, scads of money neatly tagged for research and all the time in the world—and that none of these is possessed by the practitioner. Instead, I will point out that in spite of a seemingly vast gulf of separation in facilities and resources, there are similarities of purpose which serve to give reflected dignity to any reasonable and seriously pursued clinical study even though it be attempted under primitive conditions by academic standards. The professor, gazing from the porticoed façade of a teaching hospital and contemplating his next venture into publication [SEE FIG. 1., FIG. 2. IN SOURCE PDF] (Fig. 1), looks in 1 of 3 possible directions for stimulation. Each of these corresponds with 1 of 3 responsibilities: (1) instruction of students; (2) scientific stimulation of pediatric confreres; (3) the recognition of academic superiors.

Dual effects of cisapride on gastric emptying and antropyloroduodenal motility

1993 ◽  
Vol 264 (2) ◽  
pp. G195-G201 ◽  
Author(s):  
R. Fraser ◽  
M. Horowitz ◽  
A. Maddox ◽  
J. Dent
Keyword(s):  
Gastric Emptying ◽  
Healthy Volunteers ◽  
Gastric Motility ◽  
Normal Subjects ◽  
Solid Component ◽  
Pressure Waves ◽  
Dual Effect ◽  
Intravenous Saline ◽  
Plausible Mechanism ◽  
Stimulation Of

There is little information about the effects of cisapride on human antropyloroduodenal motility, despite its documented efficacy for increasing the rate of gastric emptying in patients with gastroparesis. Cisapride has been reported to have little effect on gastric emptying in normal subjects. Antral, pyloric, and duodenal pressures were recorded simultaneously with gastric emptying in 20 healthy volunteers. Thirty minutes after the solid component of the meal had started to empty from the stomach, each subject received either 10 mg cisapride i.v. (11 subjects) or intravenous saline (9 subjects). Intravenous saline had no effect on either motility or gastric emptying. In contrast, cisapride administration was associated with a dual effect on motility, with initial suppression of antral pressure waves (P < 0.05) followed by stimulation of associated antropyloroduodenal pressure waves (P < 0.01). Gastric emptying slowed in the first 30 min after cisapride (P < 0.05), and this was followed by more rapid gastric emptying (P < 0.01). The amount of the meal emptied in the 60 min after cisapride correlated with the number of associated antroduodenal pressure waves (r = 0.75, P < 0.001) but not with the number of antral waves (r = 0.42, NS). These results indicate that cisapride in a dose of 10 mg i.v. has dual effects on gastric emptying and gastric motility. The stimulation of associated antral pressure waves is a plausible mechanism for the efficacy of cisapride in the treatment of gastroparesis.

Endorphin Release: A Possible Mechanism of Acupuncture Analgesia

1978 ◽  
Vol 06 (01) ◽  
pp. 57-60 ◽  
Author(s):  
C. H. LEE PENG ◽  
M. M. P. YANG ◽  
S. H. KOK ◽  
Y. K. WOO
Keyword(s):  
Analgesic Effect ◽  
Pain Threshold ◽  
Pain Perception ◽  
Great Increase ◽  
Biological Properties ◽  
Acupuncture Analgesia ◽  
Acupuncture Stimulation ◽  
Endogenous Substances ◽  
The Brain

The action of acupunture stimulation on analgesia has been investigated. The brain and serum extracts of acupuncture rabbits injected into rabbits produced a marked analgesic effect on the recipient, as shown by a great increase of their pain threshold. This effect is counteracted by a specific opiate anatagonist, naloxone. The data suggest that the release of the endogenous substances with morphine-like biological properties, endorphins, is increased by acupuncture stimulation, thus inhibiting pain perception.

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