MICROTUBULES AS ACTIVE TRACKS FOR BI-DIRECTIONAL CELLULAR TRAFFIC OF MOTOR PROTEINS

2007 ◽  
Vol 21 (32) ◽  
pp. 5387-5398 ◽  
Author(s):  
M. V. SATARIĆ ◽  
LJ. BUDINSKI-PETKOVIĆ ◽  
I. LONČAREVIĆ
Keyword(s):  
Electric Fields ◽  
Motor Proteins ◽  
Transport Direction ◽  
In Cells ◽  
Cellular Traffic ◽  
New View

The basic cytoskeletal transport in cells is achieved by two oppositely directed processive motor proteins, kinesin and dynein, walking along microtubules. Here, we offer a new view of the mechanism of the transport direction regulation by the intrinsic cell's electric fields that interact with kinks elicited in microtubules.

scholarly journals Models of the Collective Behavior of Proteins in Cells: Tubulin, Actin and Motor Proteins

2003 ◽  
Vol 29 (4) ◽  
pp. 401-428 ◽  
Author(s):  
J.A. Tuszynski ◽  
J.A. Brown ◽  
D. Sept
Keyword(s):  
Collective Behavior ◽  
Motor Proteins ◽  
In Cells

Cyclic AMP response in cells exposed to electric fields of different frequencies and intensities

1994 ◽  
Vol 33 (2) ◽  
pp. 141-147 ◽  
Author(s):  
G. Knedlitschek ◽  
M. Noszvai-Nagy ◽  
H. Meyer-Waarden ◽  
J. Schimmelpfeng ◽  
K. F. Weibezahn ◽  
...  
Keyword(s):  
Cyclic Amp ◽  
Electric Fields ◽  
In Cells

scholarly journals Numerical study on distribution of electric fields in cells induced by atmospheric helium plasmas

2018 ◽  
Vol 49 (1) ◽  
pp. 015201
Author(s):  
Yu LIU ◽  
HaoTian GAO ◽  
Tong ZHAO ◽  
Liang ZOU ◽  
YuanTao ZHANG
Keyword(s):  
Electric Fields ◽  
Numerical Study ◽  
In Cells

Potential therapeutic mechanism of extremely low-frequency high-voltage electric fields in cells

2016 ◽  
Vol 24 (3) ◽  
pp. 415-427 ◽  
Author(s):  
Ka-Eun Kim ◽  
Soon-Kwon Park ◽  
Sang-Yun Nam ◽  
Tae-Jong Han ◽  
Il-Young Cho
Keyword(s):  
Electric Fields ◽  
High Voltage ◽  
Low Frequency ◽  
Extremely Low Frequency ◽  
Therapeutic Mechanism ◽  
In Cells

Microtubule-Dependent Vesicle Transport: Modulation of Channel and Transporter Activity in Liver and Kidney

1998 ◽  
Vol 78 (4) ◽  
pp. 1109-1129 ◽  
Author(s):  
SARAH F. HAMM-ALVAREZ ◽  
MICHAEL P. SHEETZ
Keyword(s):  
Membrane Trafficking ◽  
Plasma Membranes ◽  
Motor Proteins ◽  
Cytoplasmic Dynein ◽  
Vesicle Transport ◽  
Directed Movement ◽  
Liver And Kidney ◽  
Transport Modulation ◽  
In Cells

Hamm-Alvarez, Sarah F., and Michael P. Sheetz. Microtubule-Dependent Vesicle Transport: Modulation of Channel and Transporter Activity in Liver and Kidney. Physiol. Rev. 78: 1109–1129, 1998. — Microtubule-based vesicle transport driven by kinesin and cytoplasmic dynein motor proteins facilitates several membrane-trafficking steps including elements of endocytosis and exocytosis in many different cell types. Most early studies on the role of microtubule-dependent vesicle transport in membrane trafficking focused either on neurons or on simple cell lines. More recently, other work has considered the role of microtubule-based vesicle transport in other physiological systems, including kidney and liver. Investigation of the role of microtubule-based vesicle transport in membrane trafficking in cells of the kidney and liver suggests a major role for microtubule-based vesicle transport in the rapid and directed movement of ion channels and transporters to and from the apical plasma membranes, events essential for kidney and liver function and homeostasis. This review discusses the evidence supporting a role for microtubule-based vesicle transport and the motor proteins, kinesin and cytoplasmic dynein, in different aspects of membrane trafficking in cells of the kidney and liver, with emphasis on those functions such as maintenance of ion channel and transporter composition in apical membranes that are specialized functions of these organs. Evidence that defects in microtubule-based transport contribute to diseases of the kidney and liver is also discussed.

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